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An improved substrate cocktail for assessing direct inhibition and time-dependent inhibition of multiple cytochrome P450s

JDMo.sinAgutaoncdatLaalybteicllianlgky2l0at0io6n. of the lytic tools; Li-shan LIN, Tao CHEN and Fei-peng ZHANG cytochrome P-450 prosthetic haem group by 1-aminobenzotriazole. analyzed the data; Ke-zhi ZHANG and Su-xing ZHANG Isolation of an NN

Evaluation of the analgesic effects of ammoxetine, a novel potent serotonin and norepinephrine reuptake inhibitor

manuscript revision. Lei ZHU helped in manuscript revision. You-zhi ZHANG and Cai-ying YE contributed to the research design and manuscript revision. 1 Bair MJ , Robinson RL , Katon W , Kroenke K. Depression

A single-dose toxicity study on non-radioactive iodinated hypericin for a targeted anticancer therapy in mice

CHEN, Guo-zhi ZHANG, Xue-bin FU, and Yi-cheng NI; literature search and manuscript drafting or editing: Jun-jie LI, Marlein Miranda CONA, Yuan-bo FENG, Feng CHEN, and Yi-cheng NI; manuscript revision for

XAB2 tagSNPs contribute to non-small cell lung cancer susceptibility in Chinese population

Background XPA-binding protein 2 (XAB2) interacts with Cockayne syndrome complementation group A (CSA), group B (CSB) and RNA polymerase II to initiate nucleotide excision repair. This study aims to evaluate the association of XAB2 genetic variants with the risk of non-small cell lung cancer (NSCLC) using a tagging approach. Methods A hospital-based case-control study was...

CYP1A2 rs762551 polymorphism contributes to cancer susceptibility: a meta-analysis from 19 case-control studies

Background Genetic polymorphism (rs762551A>C) in gene encoding cytochrome P450 1A2 (CYP1A2) has been shown to influence the inducibility of CYP1A2 expression and thus might be associated with risk of several types of human cancer. However, the results of previous studies on the associations of this polymorphism with risk of cancer are not all consistent. To clarify the potential...

Involvements of PCD and changes in gene expression profile during self-pruning of spring shoots in sweet orange (Citrus sinensis)

Background Citrus shoot tips abscise at an anatomically distinct abscission zone (AZ) that separates the top part of the shoots into basal and apical portions (citrus self-pruning). Cell separation occurs only at the AZ, which suggests its cells have distinctive molecular regulation. Although several studies have looked into the morphological aspects of self-pruning process, the...

Transcriptome profile analysis of flowering molecular processes of early flowering trifoliate orange mutant and the wild-type [Poncirus trifoliata (L.) Raf.] by massively parallel signature sequencing

Background After several years in the juvenile phase, trees undergo flowering transition to become mature (florally competent) trees. This transition depends on the balanced expression of a complex network of genes that is regulated by both endogenous and environmental factors. However, relatively little is known about the molecular processes regulating flowering transition in...

Characterization of Mycobacterium tuberculosis isolates from Hebei, China: genotypes and drug susceptibility phenotypes

Background Tuberculosis remains a major public health problem in China. The Hebei province is located in the Beijing-Tianjin-Hebei integration region; however little information about the genetic diversity of Mycobacterium tuberculosis was available in this area. This study describes the first attempt to map the molecular epidemiology of MTB strains isolated from Hebei. Methods...

Lack of association between a functional variant of the BRCA-1 related associated protein (BRAP) gene and ischemic stroke

Background Atherosclerosis shares common pathogenic features with myocardial infarction (MI) and ischemic stroke. BRCA-1 associated protein (BRAP), a newly identified risk gene for MI, aggravates the inflammatory response in atherosclerosis. The aim of this study was to test the association between the BRAP gene and stroke in a Taiwanese population. Methods A total of 1,074...

Bell-Shaped D-Serine Actions on Hippocampal Long-Term Depression and Spatial Memory Retrieval

D-Serine, the endogenous coagonist of N-methyl-D-aspartate receptors (NMDARs), is considered to be an important gliotransmitter, and is essential for the induction of long-term potentiation. However, less is known about the role of D-serine in another form of synaptic plasticity, long-term depression (LTD). In this study, we found that exogenous D-serine regulated LTD in the...

Characterization and kinetic modeling of secondary phases in squeeze cast Al alloy A380 by DSC thermal analysis

Thermal analyses on squeeze cast aluminum alloy A380 (SC A380) solidified under 90 MPa were carried out to study the microstructure development of the alloy, in which a differential scanning calorimeter (DSC) was employed. During the DSC runs, heating and cooling rates of 1, 3, 10, and 20 °C•min-1 were applied to investigate the heating and cooling effects on dissolution of...

Sulbactam/Cefoperazone Versus Cefotaxime for the Treatment of Moderate-to-Severe Bacterial Infections: Results of a Randomized, Controlled Clinical Trial

We conducted a randomized, open-label, controlled, multicenter study to compare sulbactam/cefoperazone with cefotaxime in terms of efficacy and safety for the treatment of hospitalized patients with moderate-to-severe bacterial infections. More than two-thirds of the pathogens recovered from these patients produced β-lactamase. Two hundred-seven (88.1%) of the 235 patients...

Epidermal Growth Factor Receptor Inhibition Slows Progression of Diabetic Nephropathy in Association With a Decrease in Endoplasmic Reticulum Stress and an Increase in Autophagy

Previous studies by us and others have reported renal epidermal growth factor receptors (EGFRs) are activated in models of diabetic nephropathy. In the present study, we examined the effect of treatment with erlotinib, an inhibitor of EGFR tyrosine kinase activity, on the progression of diabetic nephropathy in a type 1 diabetic mouse model. Inhibition of renal EGFR activation by...

Intrarenal Dopamine Inhibits Progression of Diabetic Nephropathy

The kidney has a local intrarenal dopaminergic system, and in the kidney, dopamine modulates renal hemodynamics, inhibits salt and fluid reabsorption, antagonizes the renin-angiotensin system, and inhibits oxidative stress. The current study examined the effects of alterations in the intrarenal dopaminergic system on kidney structure and function in models of type 1 diabetes. We...

Prognosis of ampullary cancer based on immunohistochemical type and expression of osteopontin

Background Ampullary cancer (AC) was classified as pancreatobiliary, intestinal, or other subtype based on the expression of cytokeratin 7 (CK7) and cytokeratin 20 (CK20). We aimed to explore the association of AC subtype with patient prognosis. Methods The relationship of AC subtype and expression of Osteopontin (OPN) with the prognosis of 120 AC patients after...

Efficacy and Safety of Ribavirin with Sofosbuvir Plus Ledipasvir in Patients with Genotype 1 Hepatitis C: A Meta-Analysis

Jiang Road, Yu Zhong District, Chongqing 400010 , China 1 & Da-Zhi Zhang Background Sofosbuvir and ledipasvir with or without ribavirin (RBV) regimens (SLR vs. SL) have exhibited promising results for

Microscopic optical model potential based on a Dirac Brueckner Hartree Fock approach and the relevant uncertainty analysis

A relativistic microscopic optical model potential, named CTOM, for nucleon-nucleus scattering is investigated in the framework of Dirac-Brueckner-Hartree-Fock approach. The microscopic feature of CTOM is guaranteed through rigorously adopting the isospin dependent DBHF calculation within the subtracted T matrix scheme. In order to verify its prediction power, a global study n, p...

Opportunistic Scheduling for OFDM Systems with Fairness Constraints

We consider the problem of downlink scheduling for multiuser orthogonal frequency-division multiplexing (OFDM) systems. Opportunistic scheduling exploits the time-varying, location-dependent channel conditions to achieve multiuser diversity. Previous work in this area has focused on single-channel systems. Multiuser OFDM allows multiple users to transmit simultaneously over...

The Antibacterial Activity of Mass Galla Chinesis et Camelliae Fermentata on Helicobacter pylori Infection

Correspondence should be addressed to Xue-zhi Zhang; ten.362@ihzeux.gnahz Received 24 September 2017; Revised 11 January 2018; Accepted 17 January 2018; Published 12 February 2018 Academic Editor: Youn C. Kim