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Extraction, Characterization, Antioxidant, and Immunostimulatory Activities of Polysaccharides from Hedyotis corymbosa

In this study, optimization of enzyme-assisted extraction, purification, characterization, and its bioactivities of polysaccharides from Hedyotis corymbosa (HCP) was investigated. It was found that the optimum extraction conditions were 3% of enzyme concentration (X1), 30 of liquid-to-solid ratio (X2), 56°C of extraction temperature (X3), 200W of ultrasonic power (X4), 10 min of...

The structure of Zika virus NS5 reveals a conserved domain conformation

, Riverside, Riverside, California 92521, USABoxiao Wang, Xiao-Feng Tan, Zhi-Min Zhang, Asher Lin & Jikui SongDepartment of Plant Pathology and Microbiology, University of California, Riverside, Riverside ... ScholarSearch for Stephanie Thurmond in:Nature Research journals • PubMed • Google ScholarSearch for Zhi-Min Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Asher Lin in:Nature Research

Splicing proofreading at 5′ splice sites by ATPase Prp28p

Fidelity and efficiency of pre-mRNA splicing are critical for generating functional mRNAs, but how such accuracy in 5′ splice site (SS) selection is attained is not fully clear. Through a series of yeast genetic screens, we isolated alleles of prp28 that improve splicing of suboptimal 5′SS substrates, demonstrating that WT-Prp28p proofreads, and consequently rejects, poor 5′SS...

BS69/ZMYND11 C-Terminal Domains Bind and Inhibit EBNA2

Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) plays an important role in driving immortalization of EBV-infected B cells through regulating the expression of many viral and cellular genes. We report a structural study of the tumor suppressor BS69/ZMYND11 C-terminal region, comprised of tandem coiled-coil-MYND domains (BS69CC-MYND), in complex with an EBNA2 peptide containing...

Reactivation of hypersaline aerobic granular sludge after low-temperature storage

VIC 3800, Australia, cycquc8163.com. Jia-Yue Zhu, Zhi-Min Zhang, Chongqing Jiaotong University, School of River and Ocean Engineering, Chongqing 700074, China. Yu Qin, Shao-Chun Yuan, Chongqing Jiaotong