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Soluble glucocorticoid-induced tumor necrosis factor receptor regulates Helios expression in myasthenia gravis

Helios is important for functional and phenotype stability of regulatory T cells (Tregs). However, the role of Helios in autoimmune diseases and its regulation remains unclear. This study aimed to investigate the role of Helios+ Tregs in myasthenia gravis (MG) and glucocorticoid-induced tumor necrosis factor receptor (GITR) and its ligand (GITRL) in the modulation of Helios...

The kurtosis of net baryon number fluctuations from a realistic Polyakov–Nambu–Jona-Lasinio model along the experimental freeze-out line

Firstly we qualitatively analyze the formation of the dip and peak structures of the kurtosis \(\kappa \sigma ^2\) of net baryon number fluctuation along imagined freeze-out lines and discuss the signature of the existence of the QCD critical end point (CEP) in the Nambu–Jona-Lasinio (NJL) model, Polyakov-NJL (PNJL) model as well as \(\mu \)-dependent PNJL(\(\mu \) PNJL) model...

Corrections to holographic entanglement plateau

We investigate the robustness of the Araki-Lieb inequality in a two-dimensional (2D) conformal field theory (CFT) on torus. The inequality requires that ΔS = S(L) − |S(L − ℓ) − S(ℓ)| is nonnegative, where S(L) is the thermal entropy and S(L − ℓ), S(ℓ) are the entanglement entropies. Holographically there is an entanglement plateau in the BTZ black hole background, which means...

Identifying the factors affecting bike-sharing usage and degree of satisfaction in Ningbo, China

. Supervision: Zhibin Li. Writing ± review & editing: Yanyong Guo. 18 / 19 1. Zhou X . Understanding spatiotemporal patterns of biking behavior by analyzing massive bike sharing data in Chicago . PloS one. 2015

Evaluating the impacts of grades on vehicular speeds on interstate highways

reviewers for their valuable suggestions and comments. 13 / 15 Author Contributions Conceptualization: Xinqiang Chen, Zhibin Li, Yinhai Wang. Data curation: Xinqiang Chen, Zhibin Li, Zhiyong Cui. Formal ... analysis: Xinqiang Chen, Zhibin Li, Yinhai Wang, Zhiyong Cui. Funding acquisition: Xinqiang Chen, Yinhai Wang, Huafeng Wu. Investigation: Xinqiang Chen, Zhibin Li, Zhiyong Cui. Methodology: Xinqiang Chen

On one-loop entanglement entropy of two short intervals from OPE of twist operators

Abstract We investigate the one-loop entanglement entropy of two short intervals with small cross ratio x on a complex plane in two-dimensional conformal field theory (CFT) using operator product expansion of twist operators. We focus on the one-loop entanglement entropy instead of the general order n Rényi entropy, and this makes the calculation much easier. We consider the...

Determining Sustainable Land Use by Modal Split Shift Strategy for Low Emissions: Evidence from Medium-Sized Cities of China

, Nanjing 210096, China Received 14 September 2015; Accepted 10 January 2016 Academic Editor: Yongjun Shen Copyright © 2016 Wenzhu Zhou and Zhibin Li. This is an open access article distributed under the

Determining Sustainable Land Use by Modal Split Shift Strategy for Low Emissions: Evidence from Medium-Sized Cities of China

, Nanjing 210096, China Received 14 September 2015; Accepted 10 January 2016 Academic Editor: Yongjun Shen Copyright © 2016 Wenzhu Zhou and Zhibin Li. This is an open access article distributed under the

A Fast Algorithm to Generate Feasible Solution of Production Facilities Layout Based on Plane Segmentation

For facility layout problem with continuous block and unequal area, it is key to generate feasible solution of facility layout with arbitrary space form in order to find the optimal arrangement scheme under a given goal. According to the given slicing position and slicing mode, the plane for arrangement was divided into many block areas by use of plane segmentation, which was...

Evaluating the Operational Features of an Unconventional Dual-Bay U-Turn Design for Intersections

Median U-turn intersection treatment (MUTIT) has been considered an alternative measure to reduce congestion and traffic conflict at intersection areas. The MUTIT is sometimes difficult to implement in the field because it requires wide median on arterials for U-turn vehicles. The objective of this study is to introduce an unconventional U-turn treatment (UUT) for intersections...

A Modified Cellular Automaton Approach for Mixed Bicycle Traffic Flow Modeling

Several previous studies have used the Cellular Automaton (CA) for the modeling of bicycle traffic flow. However, previous CA models have several limitations, resulting in differences between the simulated and the observed traffic flow features. The primary objective of this study is to propose a modified CA model for simulating the characteristics of mixed bicycle traffic flow...

Spatial Complexity of a Predator-Prey Model with Holling-Type Response

Lei Zhang and Zhibin Li. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided

Intensity Weighted Subtraction Microscopy Approach for Image Contrast and Resolution Enhancement

We propose and demonstrate a novel subtraction microscopy algorithm, exploiting fluorescence emission difference or switching laser mode and their derivatives for image enhancement. The key novelty of the proposed approach lies in the weighted subtraction coefficient, adjusted pixel-by-pixel with respect to the intensity distributions of initial images. This method produces...

Determining the Optimal Layout Design for Public Bicycle System within the Attractive Scope of a Metro Station

Public bicycle acts as a seamless feeder mode in combination with the citywide public transit, as well as a competitor for the inner-city short trips. The primary objective of this study is to address the layout planning of public bicycle system within the attracted scope of a metro station. Based on the land use function, population, and bicycle mode share, bicycle rental...

Determining the Optimal Layout Design for Public Bicycle System within the Attractive Scope of a Metro Station

Public bicycle acts as a seamless feeder mode in combination with the citywide public transit, as well as a competitor for the inner-city short trips. The primary objective of this study is to address the layout planning of public bicycle system within the attracted scope of a metro station. Based on the land use function, population, and bicycle mode share, bicycle rental...

Modeling the Commuting Travel Activities within Historic Districts in Chinese Cities

The primary objective of this study is to analyze the characteristics of commuting activities within the historical districts in cities of China. The impacts of various explanatory variables on commuters’ travels are evaluated using the structural equation modeling (SEM) approach. The household survey was conducted in the historical districts in Yangzhou, China. Based on the data...

Serum uric acid is independently and linearly associated with risk of nonalcoholic fatty liver disease in obese Chinese adults

The present study aimed to explore the independent association and potential pathways between serum uric acid (SUA) and nonalcoholic fatty liver disease (NAFLD). 1365 community-living obese Chinese adults who received hepatic ultrasonography scanning were included. The prevalence rates of NAFLD were 71.5% for men and 53.8% for women. Compared with controls, NAFLD subjects showed...

Efficacy of Cognitive Behavioral Therapy on Opiate Use and Retention in Methadone Maintenance Treatment in China: A Randomised Trial

Aims Methadone maintenance treatment (MMT) is widely available in China; but, high rates of illicit opiate use and dropout are problematic. The aim of this study was to test whether cognitive behavioral therapy (CBT) in conjunction with MMT can improve treatment retention and reduce opiate use. Method A total of 240 opiate-dependent patients in community-based MMT clinics were...

Cellular Automata Based Modeling for Evaluating Different Bus Stop Designs in China

A cellular automaton model is proposed to simulate mixed traffic flow composed of motor vehicles and bicycles near bus stops. Three typical types of bus stops which are common in China are considered in the model, including two types of curbside bus stops and one type of bus bay stops. Passenger transport capacity of three types of bus stops, which is applied to evaluate the bus...