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H19 potentiates let-7 family expression through reducing PTBP1 binding to their precursors in cholestasis

Scholar Search for Zhihong Yang in:Nature Research journals • PubMed • Google Scholar Search for Wendong Huang in:Nature Research journals • PubMed • Google Scholar Search for Jianguo Wu in:Nature

O-linked β-N-acetylglucosamine During Hyperglycemia Exerts Both Anti-Inflammatory and Pro-Oxidative Properties in the Endothelial System

Elevated cellular levels of protein O-linked β-N-acetylglucosamine (O-GlcNAc) through hexosamine biosynthesis pathway (HBP) are suggested to contribute to cardiovascular adverse effects under chronic hyperglycemic condition associated with oxidative stress and inflammation. Conversely, enhancing O-GlcNAc levels have also been demonstrated being protective against myocardial...

Linagliptin unmasks specific antioxidant pathways protective against albuminuria and kidney hypertrophy in a mouse model of diabetes

Conceptualization: Thomas Klein, Robert C. Stanton. Data curation: Netanya Y. Spencer, Zhihong Yang, Jensyn Cone Sullivan. Formal analysis: Netanya Y. Spencer, Zhihong Yang, Jensyn Cone Sullivan, Thomas Klein ... , Robert C. Stanton. Funding acquisition: Thomas Klein, Robert C. Stanton. Investigation: Zhihong Yang, Jensyn Cone Sullivan, Thomas Klein. Methodology: Zhihong Yang, Jensyn Cone Sullivan, Thomas Klein

Upregulations of Clcn3 and P-Gp Provoked by Lens Osmotic Expansion in Rat Galactosemic Cataract

Objective. Lens osmotic expansion, provoked by overactivated aldose reductase (AR), is the most essential event of sugar cataract. Chloride channel 3 (Clcn3) is a volume-sensitive channel, mainly participating in the regulation of cell fundamental volume, and P-glycoprotein (P-gp) acts as its modulator. We aim to study whether P-gp and Clcn3 are involved in lens osmotic expansion...

Diosgenin, a Novel Aldose Reductase Inhibitor, Attenuates the Galactosemic Cataract in Rats

Objective. To seek efficient aldose reductase inhibitors (ARIs) with excellent in vitro and in vivo biological activities against rat galactosemic cataract. Methods. The method was firstly optimized to screen strong ARIs from nonoriented synthetic compounds and natural extracts. Then, diosgenin was assessed on osmotic expansion of primarily cultured lens epithelial cells (LECs...

Diosgenin, a Novel Aldose Reductase Inhibitor, Attenuates the Galactosemic Cataract in Rats

Objective. To seek efficient aldose reductase inhibitors (ARIs) with excellent in vitro and in vivo biological activities against rat galactosemic cataract. Methods. The method was firstly optimized to screen strong ARIs from nonoriented synthetic compounds and natural extracts. Then, diosgenin was assessed on osmotic expansion of primarily cultured lens epithelial cells (LECs...

Arginase-II activates mTORC1 through myosin-1b in vascular cell senescence and apoptosis

Type-II L-arginine:ureahydrolase, arginase-II (Arg-II), is shown to activate mechanistic target of rapamycin complex 1 (mTORC1) pathway and contributes to cell senescence and apoptosis. In an attempt to elucidate the underlying mechanism, we identified myosin-1b (Myo1b) as a mediator. Overexpression of Arg-II induces re-distribution of lysosome and mTOR but not of tuberous...

Arginase-I enhances vascular endothelial inflammation and senescence through eNOS-uncoupling

Background Augmented arginase-II (Arg-II) is implicated in endothelial senescence and inflammation through a mutual positive regulatory circuit with S6K1. This study was conducted to investigate whether Arg-I, another isoform of arginase that has been also reported to play a role in vascular endothelial dysfunction, promotes endothelial senescence through similar mechanisms...

Embryonic Stem Cell Proliferation Stimulated By Altered Anabolic Metabolism From Glucose Transporter 2-Transported Glucosamine

Jung, Kumiko Iwabuchi, Zhihong Yang & Mary R. LoekenDepartment of Medicine, Harvard Medical School, Boston, MA 02115, USAJin Hyuk Jung, Kumiko Iwabuchi & Mary R. LoekenSection on Vascular Cell Biology ... • Google ScholarSearch for Zhihong Yang in:Nature Research journals • PubMed • Google ScholarSearch for Mary R. Loeken in:Nature Research journals • PubMed • Google Scholar Contributions J.H.J., K.I., Z.Y

Functions and Mechanisms of Arginase in Age-Associated Cardiovascular Diseases

Xiu-Fen Ming Zhihong Yang Advanced age is a prominent risk factor of cardiovascular and metabolic diseases, such as atherosclerosis and type II diabetes. The underlying mechanisms are complex and ... /1 and 310030_141070 1) and the Swiss Heart Foundation. Compliance with Ethics Guidelines Conflict of Interest Xiu-Fen Ming and Zhihong Yang declare that they have no conflict of interest. Human and

Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation

Fribourg, SwitzerlandChang Liu, Angana G. Rajapakse, Jean-Pierre Montani, Zhihong Yang & Xiu-Fen MingLaboratory HFR, Hospital Fribourgeois, Chemin des Pensionnats 2, 1708 Fribourg, SwitzerlandErwin Riedo ...  & Benoit FellayPromed Medical Laboratory SA, Fribourg, SwitzerlandMarie-Claire BernhardNational Center of Competence in Research “Kidney.CH”, SwitzerlandJean-Pierre Montani, Zhihong Yang & Xiu-Fen Ming

A Feedback Inhibition between miRNA-127 and TGFβ/c-Jun Cascade in HCC Cell Migration via MMP13

Citation: Yang Z, Zhang Y, Wang L ( A Feedback Inhibition between miRNA-127 and TGFb/c- Jun Cascade in HCC Cell Migration via MMP13 Zhihong Yang 0 Yuxia Zhang 0 Li Wang 0 Chun-Ming Wong, University

A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis

Patients with newly diagnosed multiple myeloma (NDMM) with high-risk disease are in need of new treatment strategies to improve the outcomes. Multiple clinical, cytogenetic, or gene expression features have been used to identify high-risk patients, each of which has significant weaknesses. Inclusion of molecular features into risk stratification could resolve the current...

p38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-Uncoupling in Obesity

Background Endothelial nitric oxide synthase (eNOS)-uncoupling links obesity-associated insulin resistance and type-II diabetes to the increased incidence of cardiovascular disease. Studies have indicated that increased arginase is involved in eNOS-uncoupling through competing with the substrate L-arginine. Given that arginase-II (Arg-II) exerts some of its biological functions...

Randomized comparison of next-generation sequencing and array comparative genomic hybridization for preimplantation genetic screening: a pilot study

Background Recent advances in next-generation sequencing (NGS) have provided new methods for preimplantation genetic screening (PGS) of human embryos from in vitro fertilization (IVF) cycles. However, there is still limited information about clinical applications of NGS in IVF and PGS (IVF-PGS) treatments. The present study aimed to investigate the effects of NGS screening on...

Selection of competent blastocysts for transfer by combining time-lapse monitoring and array CGH testing for patients undergoing preimplantation genetic screening: a prospective study with sibling oocytes

Background Recent advances in time-lapse monitoring in IVF treatment have provided new morphokinetic markers for embryonic competence. However, there is still very limited information about the relationship between morphokinetic parameters, chromosomal compositions and implantation potential. Accordingly, this study aimed at investigating the effects of selecting competent...

Cross-Regulation of Protein Stability by p53 and Nuclear Receptor SHP

We report here a novel interplay between tumor suppressor p53 and nuclear receptor SHP that controls p53 and SHP stability. Overexpression of p53 causes rapid SHP protein degradation, which does not require the presence of Mdm2 and is mediated by the proteosome pathway. Overexpressing SHP alone does not affect p53 stability. However, SHP destabilizes p53 by augmentation of Mdm2...

Selection of euploid blastocysts for cryopreservation with array comparative genomic hybridization (aCGH) results in increased implantation rates in subsequent frozen and thawed embryo transfer cycles

thawed embryo transfer cycles Zhihong Yang 0 Shala A Salem 0 Xiaohong Liu Yanping Kuang Rifaat D Salem 0 Jiaen Liu 0 ART and PGD Program, Pacific Reproductive Center , Torrance, CA , USA Background: In

In Vivo Measurement of Oxygenation Changes after Stroke Using Susceptibility Weighted Imaging Filtered Phase Data

Background and Purpose Cerebral blood oxygenation level is critical for following the evolution of stroke patients. The purpose of this study was to investigate the feasibility of measuring changes in blood oxygen levels for patients with acute stroke using SWI and to compare these changes with the patient's recovery over time. Materials and Methods A total 30 MRI scans was...