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Synthetic wavelength interferometry of an optical frequency comb for absolute distance measurement

Shilin Xiong in:Nature Research journals • PubMed • Google Scholar Search for Guoyuan Li in:Nature Research journals • PubMed • Google Scholar Search for Zhijian Cai in:Nature Research journals • PubMed

Fas Signaling Promotes Gastric Cancer Metastasis through STAT3-Dependent Upregulation of Fascin

Background Fas signaling-activated signal transducers and activators of transcription 3 (STAT3) is required for Fascin upregulation. As an actin-bundling protein, Fascin can mediate gastric cancer (GC) cell migration. Methods Gastric cancer AGS cells were treated with anti-Fas (5 μg/ml) for 2 h, in order to stimulate the activation of the Fas signaling. The in vitro migration of...

EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance

ScholarSearch for Keyi Wang in:Nature Research journals • PubMed • Google ScholarSearch for Jianli Wang in:Nature Research journals • PubMed • Google ScholarSearch for Zhijian Cai in:Nature Research journals ... ; Z.C. and L.J. wrote the paper. Competing interests The authors declare no competing financial interests. Corresponding authors Correspondence to Jianli Wang or Zhijian Cai. Supplementary information

IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production

Interleukin 4-induced gene-1 (IL4I1) was initially described as an early IL-4-inducible gene in B cells. IL4I1 protein can inhibit T cell proliferation by releasing its enzymatic catabolite, H2O2, and this effect is associated with transient down-regulation of T cell CD3 receptor-zeta (TCRζ) expression. Herein, we show that IL4I1 contributes to the regulation of macrophage...

Immunosuppressive exosomes from TGF-β1 gene-modified dendritic cells attenuate Th17-mediated inflammatory autoimmune disease by inducing regulatory T cells | Cell Research Zhijian Cai et al. npg 609 npg Treatment of IBD by immunosuppressive exosomes by treatment with TGF-?1-EXO. This is the first report about utilizing exosomes that were derived from

MCPIP1 Down-Regulates IL-2 Expression through an ARE-Independent Pathway

IL-2 plays a key role in the survival and proliferation of immune cells, especially T lymphocytes. Its expression is precisely regulated at transcriptional and posttranscriptional level. IL-2 is known to be regulated by RNA binding proteins, such as tristetraprolin (TTP), via an AU-rich element (ARE) in the 3′-untranslated region (3′UTR) to influence the stability of mRNA. MCPIP1...