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Targeting of HER3 with Functional Cooperative miRNAs Enhances Therapeutic Activity in HER2-Overexpressing Breast Cancer Cells

BackgroundThe HER3 receptor functions as a major cause of drug resistance in cancer treatment. It is believed that therapeutic targeting of HER3 is required to improve patient outcomes. It is not clear whether a novel strategy with two functional cooperative miRNAs would effectively inhibit erbB3 expression and potentiate the anti-proliferative/anti-survival effects of a HER2...

High-Efficiency Preparation of 2,5-Diformylfuran with a Keto-ABNO Catalyst Under Mild Conditions

In this paper, we report a new catalytic system for realizing the rapid and efficient oxidation of 5-hydroxymethylfurfural (HMF). First, we used 9-azabicyclo [3.3.1]nonan-3-one-N-oxyl (keto-ABNO) as a catalyst for the aerobic oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-diformylfuran (DFF) in acetic acid. Then, we systematically studied the important reaction parameters...

Chemical Composition of Corrosion Products of Rebar Caused by Carbonation and Chloride

The microstructures of steel bars were studied by X-ray photoelectron spectroscopy (XPS), and the mechanism of corrosion of steel bars under the corrosion factors was elucidated. The results show that the passivation film and corrosive surface of the steel surface in the solution of the chloride-containing salt were coarser and the surface state was denser. The main corrosion...

Chemical Composition of Corrosion Products of Rebar Caused by Carbonation and Chloride

The microstructures of steel bars were studied by X-ray photoelectron spectroscopy (XPS), and the mechanism of corrosion of steel bars under the corrosion factors was elucidated. The results show that the passivation film and corrosive surface of the steel surface in the solution of the chloride-containing salt were coarser and the surface state was denser. The main corrosion...

Poly (γ-Glutamic Acid) Promotes Enhanced Dechlorination of p-Chlorophenol by Fe-Pd Nanoparticles

Nanoscale zero-valent iron (nZVI) has shown considerable promise in the treatment of chlorinated organic compounds, but rapid aggregation and inactivation hinder its application. In this study, palladium-doped zero-valent iron nanoparticles involving poly (γ-glutamic acid) (Fe-Pd@PGA NPs) were synthesized. The nanoparticles were small (~100 nm), uniformly distributed, and highly...

Epigenetic mechanism of survivin dysregulation in human cancer

Survivin (coding gene BIRC5) is a dual functional protein acting as a critical inhibitor of apoptosis (IAP) and key regulator of cell cycle progression. It is usually produced in embryonic tissues during development and undetectable in most adult tissues. Overexpression of Survivin frequently occurs in various human cancers and increased Survivin correlates with poor clinic...

Molecularly Imprinted Core-Shell CdSe@SiO2/CDs as a Ratiometric Fluorescent Probe for 4-Nitrophenol Sensing

4-Nitrophenol (4-NP) is a priority pollutant in water and is both carcinogenic and genotoxic to humans and wildlife even at very low concentrations. Thus, we herein fabricated a novel molecularly imprinted core-shell nanohybrid as a ratiometric fluorescent sensor for the highly sensitive and selective detection of 4-NP. This sensor was functioned by the transfer of fluorescence...

Annexin A2 contributes to cisplatin resistance by activation of JNK-p53 pathway in non-small cell lung cancer cells

Liu 0 Zhijie Zhang Yixue Gu Huisi Qiu Zhimin He 0 Equal contributors Cancer Hospital and Cancer Research Institute, Guangzhou Medical University , Guangzhou, No.78 hengzhigang Road, Guangzhou 510095

ADAM12-L confers acquired 5-fluorouracil resistance in breast cancer cells

Research journals • PubMed • Google Scholar Search for Zhimin He in:Nature Research journals • PubMed • Google Scholar Search for Xinhui Wang in:Nature Research journals • PubMed • Google Scholar Search

Multiplicity of solutions for impulsive differential equation on the half-line via variational methods

In this paper, the existence of solutions for a second-order impulsive differential equation with two parameters on the half-line is investigated. Applying variational methods, we give some new criteria to guarantee that the impulsive problem has at least one classical solution, three classical solutions and infinitely many classical solutions, respectively. Some recent results...

Stability of sets of stochastic functional differential equations with impulse effect

In this paper, we study the stability of sets for a class of impulsive stochastic functional differential equations. By employing piecewise continuous Lyapunov functions with Razumikhin methods, some sufficient conditions are established to guarantee the stability of sets of impulsive stochastic functional differential equations and we also show that the impulses play an...

Multiple homoclinic orbits for second order discrete Hamiltonian systems without symmetric condition

In this paper, we investigate the second order self-adjoint discrete Hamiltonian system Δ [ p ( n ) Δ u ( n − 1 ) ] − L ( n ) u ( n ) + λ a ( n ) ∇ G ( u ( n ) ) + μ b ( n ) ∇ F ( u ( n ) ) = 0 , where p , L : Z → R N × N are both positive definite for all n ∈ Z , and no symmetric condition on G and F is needed. We establish two new criteria to guarantee that the above system has...

Homoclinic orbits for damped vibration systems with asymptotically quadratic or subquadratic potentials

In this paper, we study a class of damped vibration systems, u ¨ ( t ) + B u ˙ ( t ) − L ( t ) u ( t ) + ∇ W ( t , u ( t ) ) = 0 , ∀ t ∈ R , where W ( t , u ) is of indefinite sign. By using a critical point theorem of Ding, we establish a new criterion to guarantee that the above system has infinitely many nontrivial homoclinic orbits under the assumption that W ( t , u ) is...

Highly Efficient Catalysis of Azo Dyes Using Recyclable Silver Nanoparticles Immobilized on Tannic Acid-Grafted Eggshell Membrane

In this study, a facile one-step synthesis of a novel nanocomposite catalytic film was developed based on silver nanoparticles (AgNPs) immobilized in tannic acid-modified eggshell membrane (Tan-ESM). Tannic acid, as a typical plant polyphenol from oak wood, was first grafted onto ESM fibers to serve as both the reductant and the stabilizer during the synthesis of AgNPs. The...

1 : 3 Resonance and Chaos in a Discrete Hindmarsh-Rose Model

; Accepted 30 November 2014; Published 17 December 2014 Academic Editor: Zhidong Teng Copyright © 2014 Bo Li and Zhimin He. This is an open access article distributed under the Creative Commons Attribution

1 : 3 Resonance and Chaos in a Discrete Hindmarsh-Rose Model

; Accepted 30 November 2014; Published 17 December 2014 Academic Editor: Zhidong Teng Copyright © 2014 Bo Li and Zhimin He. This is an open access article distributed under the Creative Commons Attribution

TCP2 positively regulates HY5/HYH and photomorphogenesis in Arabidopsis

Light regulates plant growth and development via multiple photoreceptors including phytochromes and cryptochromes. Although the functions of photoreceptors have been studied extensively, questions remain regarding the involvement of cryptochromes in photomorphogenesis. In this study, we identified a protein, TEOSINTE-LIKE1, CYCLOIDEA, and PROLIFERATING CELL FACTOR 2 (TCP2), which...

Complex dynamic behavior of a discrete-time predator-prey system of Holling-III type

In this paper, we investigate the dynamics of a discrete-time predator-prey system of Holling-III type in the closed first quadrant R+2. Firstly, the existence and stability of fixed points of the system is discussed. Secondly, it is shown that the system undergoes a flip bifurcation and a Neimark-Sacker bifurcation in the interior of R+2 by using bifurcation theory. Finally...

Infinitely many homoclinic solutions for a class of second-order Hamiltonian systems

In this paper, we deal with the existence of infinitely many homoclinic solutions for a class of second-order Hamiltonian systems. By using the dual fountain theorem, we give some new criteria to guarantee that the second-order Hamiltonian systems have infinitely many homoclinic solutions. Some recent results are generalised and significantly improved.MSC: 34B08, 34B15, 34B37...

Calcium-Ion-Triggered Co-assembly of Peptide and Polysaccharide into a Hybrid Hydrogel for Drug Delivery

We report a new approach to constructing a peptide–polysaccharide hybrid hydrogel via the calcium-ion-triggered co-assembly of fluorenylmethyloxycarbonyl-diphenylalanine (Fmoc-FF) peptide and alginate. Calcium ions triggered the self-assembly of Fmoc-FF peptide into nanofibers with diameter of about 30 nm. Meanwhile, alginate was rapidly crosslinked by the calcium ions, leading...