Insulin resistance (IR)-related indices and moderate-to-vigorous physical activity (MVPA) were independent predictors for cardiometabolic disease (CMD) and multimorbidity (CMM), but their combined effect is unclear. We aimed to investigate their joint effect on incident CMD and CMM. This study was conducted from the UK Biobank accelerometer sub-study. The IR-related indices...
National utilization trends of lipid-lowering therapy (LLT) have been studied for a subgroup of patients insured in Switzerland between 2013 and 2019. In 2019, the European Society of Cardiology (ESC) released new guidelines on the management of dyslipidaemia providing novel cholesterol targets. Additionally, new lipid-lowering compounds and combination drugs have been introduced...
Dysbetalipoproteinaemia (dysβ) is a genetic lipid disorder characterised by accumulated remnant lipoproteins, leading to mixed hyperlipidaemia and increased cardiovascular risk. It is primarily associated with apolipoprotein E (apoE) ε2/ε2 homozygosity, although variants, such as arginine 145 cysteine (R145C), may also contribute. In sub-Saharan Africa, including Ghana, dysβ...
Stroke continues to be a predominant contributor to morbidity and mortality, with insulin resistance (IR) recognized as a significant risk factor. The predictive utility of cumulative IR-related indices for assessing stroke risk across varying glucose regulation statuses remains ambiguous. The present study investigated the associations between six cumulative IR-related indices...
To evaluate the predictive value of the atherogenic index of plasma (AIP) for coronary artery calcification (CAC), carotid atherosclerosis (CA), and their coexistence, and to develop a multidimensional risk prediction model to optimize early cardiovascular disease (CVD) screening. A total of 32,992 individuals who underwent carotid intima–media thickness (CIMT) measurement and...
Lipoprotein(a) [Lp(a)] is a known independent risk factor for cardiovascular disease, yet awareness and management remain limited. The psychosocial implications of elevated Lp(a)-levels have been poorly characterized. To compare cardiovascular outcomes and cardiovascular risk factor (CVRF) modification in individuals with normal vs. elevated Lp(a) levels, and to assess the impact...
Currently total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) are used in clinical practice to estimate future cardiovascular risk. We assessed whether other lipoprotein subclasses also contribute to cause-specific and all-cause mortality in the general population. Two independent cohorts of the Study of Health in Pomerania (SHIP-START and SHIP-TREND) were used...
Self-harm is a significant public health concern, with increasing prevalence globally. Omega-3 fatty acids (FAs), particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are known for their health benefits, including potential mental health improvements. This study explores the association between omega-3 FAs and self-harm behaviors using data from the UK Biobank...
Delirium is a common neuropsychiatric complication following major gastrointestinal surgery and is associated with poor postoperative outcomes. Patients undergoing gastric surgery often experience significant metabolic stress and insulin resistance, which may contribute to delirium. The triglyceride-glucose (TyG) index is a simple surrogate marker of insulin resistance, but its...
As emerging biomarkers for stroke risk, the clinical value of the atherogenic index of plasma and a body shape index has gained increasing attention. However, current research on their combined use for stroke risk stratification remains limited. This study aims to analyze the combined effects of Atherogenic Index of Plasma (AIP) and A Body Shape Index (ABSI) trajectories to...
Effective lipid management is critical for secondary stroke prevention, however, many patients fail to achieve target low-density lipoprotein cholesterol (LDL-C) levels with statin monotherapy. This study evaluated the real-world effectiveness and safety of switching from statin monotherapy to rosuvastatin plus ezetimibe combination therapy (REZ) in patients with stroke. This...
The relationship between vitamin D deficiency and the uric acid-to-high-density lipoprotein cholesterol ratio (UHR) in postmenopausal women remains unclear. This study aims to investigate the association between these variables and to evaluate the potential interaction between UHR and waist circumference (WC). Data from 5,155 postmenopausal women who participated in the National...
Metabolic diseases, a major challenge in global public health, are commonly characterized by insulin resistance, lipid metabolism disorders, and mitochondrial dysfunction, and their pathological processes are often accompanied by the abnormal accumulation of lipids in metabolically active tissues such as the liver, heart, and skeletal muscle. Recently, lipid droplets and...
Obesity is a global health concern linked to metabolic disorders and gut microbiota dysbiosis, particularly under high-fat diet (HFD) conditions. This study explores the role of imidazole propionate (ImP), a histidine-derived microbial metabolite, in regulating lipid metabolism and the development of obesity. Male C57BL/6 mice were fed either a chow diet or HFD for 15 weeks...
Accurate stratification of recurrence risk after curative resection remains a critical challenge in the management of hepatocellular carcinoma (HCC). Dysregulated ceramide (CER) metabolism has been implicated in HCC progression and relapse. This paper evaluates whether preoperative plasma CER profiling coupled with machine learning (ML) enhances the risk prediction of HCC...
Cardiovascular disease (CVD) has been documented to be related with the triglyceride glucose (TyG) index. However, limited research has explored the change in the triglyceride glucose-waist circumference (TyG-WC) index in relation to CVD, particularly among individuals with prediabetes and diabetes. Thus, this longitudinal analysis aimed to investigate the association between...
Recent studies highlighted the independent role of remnant cholesterol (RC) on the risk of atherosclerotic cardiovascular disease (ASCVD). We explored interrelationships among low-density lipoprotein cholesterol (LDL-C), RC, and ASCVD in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). Analyzing 25,418 MASLD and 57,501 non-MASLD ASCVD- free...
Obesity and excessive body fat lead to metabolic and inflammatory disturbances. The fat mass index (FMI) has recently been recognized as a more sensitive measure of obesity than body mass index (BMI). Therefore, we investigated the relationship between higher FMI and alterations in platelet phospholipid fatty acid (FA) composition, oxidative stress, and inflammation. Cross...
Residual cardiovascular risk persists in patients with hypercholesterolemia despite lipid-lowering therapy, underscoring the importance of inflammation in ASCVD development. This study evaluated the relationship between Systemic Inflammation Response Index (SIRI) (a composite biomarker derived from neutrophil, monocyte, and lymphocyte counts) and ASCVD in patients with...
Sarcopenia, the progressive depletion of skeletal muscle mass and strength, worsens daily living outcomes and survival in individuals diagnosed with cancer. It arises from complex interactions between primary malignancy, antineoplastic interventions, and treatment-related sequelae, making early risk assessment a clinical priority. The body roundness index (BRI), an anthropometric...
This study evaluated associations between several obesity indicators and the risks of Crohn’s disease (CD) and ulcerative colitis (UC), the two principal clinical phenotypes of inflammatory bowel disease (IBD). Data from 479,590 UK Biobank participants (mean age ± standard deviation: 56.5 ± 8.09 years; 54.5% female) were analyzed. Participants were classified based on waist...
Heart failure with preserved ejection fraction (HFpEF) and chronic kidney disease (CKD) frequently coexist and portend a poor prognosis. Insulin resistance (IR) is implicated in cardiorenal pathophysiology, but practical surrogate IR indices for predicting risk in this high-risk and understudied population are lacking. This study evaluated and compared the prognostic value of...
To investigate the associations of systemic inflammation, lipid metabolism, bone metabolism markers, and muscle quality with thoracic aortic calcification (TAC) in patients undergoing maintenance dialysis. This multicenter cross-sectional research involved 1916 patients aged 18–80 years who underwent maintenance dialysis across four tertiary hospitals in China between January...