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Psychedelic medicine is a rapidly growing, billion-dollar industry poised to transform mental health care by incorporating spiritual experiences into clinical psychiatry. However, while the blending of psychiatry and mystical experience has long made this field unique, the blurred boundaries between science and spiritual practice have sparked increasing public debate. What does...
Our usual explication of a logic through an axiomatic calculus is structurally foundationalist. Justification gets transferred by applying rules finitely many times from already justified sentences to new sentences in a linear-like fashion, by starting from a base of non-to-be justified sentences (i.e. the axioms). In contrast, this paper develops a coherentist approach to...
In today’s world, understanding the role of effective water management is crucial for promoting sustainable development. It is essential to focus on strategies that balance resource conservation with the demands of growing communities. In this regard, this study focuses on developing a decision support system to enhance the planning and implementation of water infrastructure...
This paper investigates the asymptotic behavior of solutions to \(u_t=\Delta u+|u|^{p-1}u\) in the Sobolev critical case. Our main result is a classification of the dynamics near the ground states in the six dimensional case. It is shown that if the initial data \(u_0\in H^1({\mathbb R}^6)\) satisfies \(\Vert u_0-\textsf{Q}\Vert _{\dot{H}^1({\mathbb R}^6)}\ll 1\), then the...
Plant meiosis constitutes a critical vulnerability under unfavorable conditions in plant reproduction. In the 21st century, with the accelerating global climate change, environmental stresses increasingly compromise fertility and genetic stability. This review examines the role of abiotic stress factors - including heat, cold, drought, salinity, heavy metals, and oxidative stress...
The research focuses on the modification of the microstructure in high-pressure diesel engines through improvements in the austempering process. Unstable conditions during the austempering treatment led to the formation of undesirable microstructural features, including non-uniform subsurface decarburization, excessive carbide precipitation, and regions of pearlitic phases due to...
This article reconstructs the economic dimension of Bruno Leoni’s thought, focusing on a part of his work that has often remained in the background when his legacy is approached primarily through legal and political lenses. Drawing on his essays and reviews in Il Politico, together with Freedom and the Law and later collected papers, the study shows that Leoni engaged in a...
Background Although electrocutions commonly occur at domestic voltages of 100–240 V worldwide, fatal electrical injuries at voltages below 100 V are uncommon. We report an unusual fatal case of electrocution associated with a single 9 V dry cell battery. Case presentation A man in his 30s was found dead with metal wires inserted into the skin of his chest. The wires were...
Alignment accuracy of micropatterns is a critical factor affecting the performance of products in industrial applications. In multilayer structures, where patterns of different shapes must be precisely superimposed, even slight misalignments can significantly degrade performance, necessitating high-precision alignment. Conventional alignment techniques rely on alignment marks...
This numerical study employs a computational model of human hepatic blood flow to investigate the hemodynamic consequences of cirrhosis. The liver receives blood through a dual-inlet system (portal vein and hepatic artery) that perfuses a complex network of sinusoids; however, cirrhosis-induced fibrosis distorts these channels, increasing hydraulic resistance. In turn, portal...
Despite extensive theoretical work on Manning’s roughness coefficient (n) in hydraulic literature, its numerical validity across multiple scales in two-dimensional depth-averaged (2DH) frameworks remains poorly quantified. This study addresses this gap by developing a systematic multi-scale calibration protocol applied to a complex reach of a large alluvial river. The novelty...
The ultraviolet (UV) spectral domain occupies a unique position in stellar astrophysics, serving as the bridge between the thermal continuum of photospheres and the high-energy, non-thermal processes of stellar coronae and winds. This article provides a review of stellar physics in the UV, addressing both the theoretical framework and observational applications across the...
Introduction Ameloglyphics, the study of enamel rod-end patterns, or "tooth prints," has emerged as a promising forensic tool. Its application in human identification is documented, but data on comparative morphology across human and non-human mammalian species remain limited. Differentiating the species is crucial in forensic contexts such as mass disasters, wildlife forensics...
More than two decades have passed since the first identification of the ARP2/3 complex in plants. During this time, numerous studies have advanced our understanding of the complex’s role in actin cytoskeleton regulation. However, compared with opisthokonts, the mechanisms and functional contexts of ARP2/3 activity in plants remain only partially understood. Since the last...
Purpose of review We aim to evaluate the efficacy of risk-based surveillance strategies for hepatocellular carcinoma (HCC) in chronic hepatitis B virus (HBV) patients, addressing key questions: How can risk stratification enhance early detection? What are cost-effective approaches across diverse settings? How may novel diagnostic tools enhance surveillance? Recent findings Recent...
The osteocyte network embedded in bone tissues plays a central role in the control of bone adaptation to mechanical loads and micro-damage repair. However, much remains to be understood about the precise mechanisms by which the osteocyte network regulates bone formation and bone resorption based on the propagation of biochemical signals emitted in response to mechanical stimulus...
Urban floods increasingly pose threats to transportation systems, residential areas, and public safety, which has created an urgent need for rapid urban flood susceptibility mapping (UFSM) under varying rainfall conditions. In this study, five tree-based machine learning models, namely, random forest (RF), extreme gradient boosting (XGBoost), light gradient boosting machine...
We consider a bivariate first hitting-time model in which durations are the crossing times of dependent compound Poisson processes with fixed thresholds. The identifiability of the model is discussed, and likelihood estimators of the model parameters are proposed. We obtain the asymptotic properties of the estimators and underline their finite sample performance with a simulation...
Background Sudden cardiac death is defined as an unexpected natural death of presumed cardiac origin that occurs within a short interval, usually within 1 h of symptom onset, in individuals with or without previously known heart disease. Epidemiological data based on autopsy-confirmed cases of sudden cardiac death in Brazil remain limited. Objective We aimed to describe the...
This study presents a comparative scientometric analysis of 526 publications from the Web of Science Core Collection and China National Knowledge Infrastructure (CNKI) database to decode the global research trajectory on urban green space (UGS) carbon sinks and to delineate China’s distinctive role. Analysis reveals a clear evolution in research focus and output. Early work...
Background Only a minority of patients with advanced gastric cancer (GC) or esophagogastric junction (EGJ) adenocarcinoma derive durable benefit from anti-programmed cell death 1 (PD-1) therapy. However, reliable biomarkers for real-world clinical decision-making remain limited. Objective To identify tumor site-specific genomic alterations associated with outcomes of nivolumab...
Early detection of bearing faults is vital for ensuring the reliability and safety of rotating machines such as automobile wheels and power plant turbines, because undetected degradation may lead to unexpected failures and operational risks. As bearings deteriorate, vibration signals exhibit characteristic changes reflecting underlying mechanical issues. Machine learning (ML) and...
This article reviews the short-, medium-, and long-term prospects for characterizing rocky exoplanets, a central goal of contemporary astrophysics. The primary objectives are to determine whether these planets host atmospheres; if so, to constrain their molecular composition and search for potential biosignatures; if not, to infer their surface composition and thereby enabling a...
Mechanical ventilation is a life-saving therapeutic intervention for patients with impaired pulmonary function, yet it carries the risk of ventilator-induced lung injury (VILI). At bedside, physicians face the challenge of keeping lung tissue in a healthy state while ensuring sufficient gas exchange. Gas exchange occurs between the air in the alveoli and the dense network of...
Accurate estimation of seepage loss from lined irrigation canals is essential for improving irrigation efficiency and water sustainability. This study evaluates and compares five deep learning (DL) models, namely a deep neural network (DNN), convolutional neural network (CNN), recurrent neural network (RNN), long short-term memory network (LSTM), and bidirectional long short-term...
Delays experienced by orphanage children in accessing formal education can affect their cognitive, social, emotional, and academic development. These conditions contribute to limited basic literacy and numeracy skills and reduce children’s self-confidence in social interactions. This study aims to analyze the factors causing delays in formal education among orphanage children and...