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Bringing Uncle Chatty Gee (ChatGPT) into the classroom: a lens from Critical Indigenous Studies
This article critically examines the integration of generative artificial intelligence (AI) technologies, such as “Uncle Chatty Gee” (ChatGPT), within tertiary Indigenous Studies classrooms, using a Critical Indigenous Studies lens. It highlights the risks posed by AI to Indigenous knowledges, pedagogies, and cultures, including issues of inaccuracy, the misappropriation and...
Frequency of mixed neuropathologies in individuals with Down syndrome with and without Alzheimer's dementia
Individuals with Down syndrome (DS) develop Alzheimer's disease neuropathological change (ADNC) by the age of 40 years, and most develop dementia by their early 50s. The frequency of co-pathologies in clinically and neuropathologically characterized adults with DS has not been systematically characterized. We characterized the frequency of ADNC and common co-pathologies...
Regulatory mechanisms of LGR4 on cancer and cancer stem cell properties
Leucine-rich repeats containing G protein-coupled receptor 4 (LGR4) is a receptor belonging to the G-protein-coupled receptor superfamily. LGR4 can be activated by ligands such as R-spondins (RSPOs), Norrin, and the ligand of the receptor activator of nuclear factor kappa-B(RANKL) to regulate signaling pathways in both normal and pathological processes. LGR4 is widely expressed...
A reparative neutrophil subpopulation accelerates spinal cord regeneration in zebrafish by controlling macrophage inflammation via Il-4
In mammals, a dysregulated immune response is detrimental to spinal cord repair. In zebrafish, which are capable of spinal cord regeneration, the immune response promotes regeneration. Neutrophils are the first immune cells to arrive at a spinal cord injury site, but their role in successful regeneration is not fully understood. Here we show that ablating neutrophils, including a...
Sperm tRNA-derived fragments: molecular mechanisms and clinical implications for paternal epigenetic inheritance
Sperm tRNA-derived fragments (tRFs) have emerged as novel regulators of paternal epigenetic inheritance. By modulating embryonic epigenetic reprogramming, transposon silencing, and intergenerational genetic programming, tRFs mediate the transgenerational transmission of paternal environmental information, extending conventional notions of genetic inheritance. This review...
A standardized technique for high-fidelity venous perfusion of human limbs for anatomical education and surgical skills training
A comprehensive three‑dimensional understanding of limb venous anatomy, including venous pathways, valve distribution, and superficial–deep connections, is essential for anatomical education and preclinical surgical training. However, preparation of venous anatomical specimens remains technically challenging because of venous valves, fragile vessel walls, leakage, and incomplete...
Exosome-mediated bone immune regulation and multi-mechanism intervention: a novel strategy for the treatment of postmenopausal osteoporosis
Postmenopausal osteoporosis (PMOP) is a bone metabolic disorder primarily triggered by estrogen deficiency, characterized by reduced bone mass, deterioration of bone microarchitecture, and an increased risk of fractures. Although conventional therapeutic strategies can partially alleviate bone resorption, they often exert adverse side effects and struggle to rectify the...
Multifunctional Textile Electronics Based on Triboelectric Nanogenerator with Electrochemical Synergy for Parkinson’s Disease Management
Parkinson’s disease (PD) affects tens of millions of people globally, yet current clinical management remains fragmented, relying on subjective assessments and episodic laboratory measurements that fail to capture disease dynamics in real-world settings. Here, we present a smart textile-integrated multimodal interface (STMI) that seamlessly combines tremor quantification with...
From animal models to NAMs: a paradigm shift in developmental immunotoxicity testing
Developmental immunotoxicology (DIT) is emerging as a critical area in regulatory toxicology, driven by the recognition that the developing immune system is particularly vulnerable to xenobiotic exposure. Disruptions occurring during fetal or early postnatal life may result in long-lasting alterations in immune competence, tolerance, and disease susceptibility. This review...
Clinical outcomes and practical management implications in rudimentary horn pregnancies: a systematic review and pooled analysis (2010–2025)
Purpose Rudimentary horn pregnancies are rare and carry significant maternal and fetal risks. This study aims to systematically review published cases of rudimentary horn pregnancies describing data about time of diagnosis, time of rupture, and live birth rate (LBR), with exploratory comparisons between communicating (CHP) and non-communicating horn pregnancies (NCHP). Methods A...
A deep hybrid CNN-BiLSTM-BiGRU architecture with explainability for mild cognitive impairment detection using EEG
Accurate detection of Mild Cognitive Impairment (MCI) is critical for timely intervention and for slowing progression to Alzheimer’s disease. Electroencephalography (EEG) offers a non-invasive and cost-effective measure of brain activity; however, its complex, non-linear dynamics limit conventional analysis. We propose a CNN-Res-SE-BiLSTM-BiGRU framework for the automated...
Institutional experience and pooled survival analysis of chemotherapy based multimodal management in poorly differentiated chordoma
Background Poorly differentiated chordoma (PDC) is an exceptionally rare bone tumor with aggressive behavior and early recurrence. Evidence on the role and integration of chemotherapy remains limited. We aimed to share our institutional management experience and identify clinical prognostic factors in PDC. Methods Five consecutive patients with axial PDC treated at our spinal...
Facilitators’ perspectives on a pre-matriculation program in basic biomedical sciences for medical students: a qualitative study
Background Pre-matriculation programs are commonly used to help new medical students transition into medical school, especially when students come from varied educational background. Little is known about facilitators’ perspectives, even though they play a key role in designing and delivering these programs. This study aimed to explore facilitators’ views on the effectiveness...
Regelschulungen oder interaktive Awareness-Trainings – Was hilft bei der Prävention organisationaler Kriminalität?
Compliance trainings often fail to counteract the Ebbinghaus forgetting curve, and there is little scientific evidence that they sustainably prevent misconduct. Against this backdrop, the article examines whether and how different training formats can produce lasting preventive effects in organizations.The paper reports on a quasi-experimental intervention study in a large...
Randomized Controlled Trials Comparing the Standard of Care to Alternative Treatments in Patients with Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma: A Systematic Literature Review
Introduction Standard of care (SoC) for resectable locally advanced head and neck squamous cell carcinoma (LA-HNSCC) is surgery with adjuvant radiotherapy (RT) or chemoradiotherapy (for tumors at high risk of recurrence). As long-term prognosis is suboptimal with SoC, this study aimed to summarize findings from recent studies comparing alternative treatments to SoC. Methods A...
Inpatient utilization among Medicaid members with substance use disorder in Oregon
Background In the United States, substance use disorders (SUDs) remain a critical public health concern with significant morbidity and mortality. Oregon exemplifies this crisis with high rates of illicit drug use and overdose deaths, compounded by systemic challenges like behavioral health workforce shortages. This study’s objective is to characterize patterns of acute care...
The elephant (bird) in the room: unknown mechanisms and unresolved impacts of low DNA yields in avian microbiome research
To holistically understand the biology of animals, we must unravel the complexities and specificities of host-microbe interactions across animal taxa. Birds represent enigmatic and scientifically compelling hosts in which to understand these interactions. Here, we present a brief summary of a series of conversations among avian microbiome researchers regarding methodological...
Coupled experimental–computational study of Lapidus plates for the high-performance of surgical techniques for hallux hypermobility correction
Background For the correction of Hallux hypermobility through surgery, Lapidus plates have been studied as surgical fixation devices to evaluate the procedure’s success and its implications for biomechanical foot performance. However, significant knowledge gaps persist regarding the behavior of these devices and their biomechanical characteristics following implantation. Methods...
A continuum of disconnection: the impacts of safer supply program closures on continuity of care, transition, and total loss of service access
Objective In March 2025, the expiration of federal pilot funding for Safer Supply Programs (SSPs), combined with restrictive provincial legislative changes to harm reduction service provision in Ontario, disrupted care for thousands of clients at risk of toxic drug poisoning. This study examines the impacts of these changes on client health, social stability, and overdose risk...
CT-adipose measures identify severe SARS-CoV-2 risk beyond traditional obesity metrics: a C4R cohort study
Background Higher body mass index (BMI) increases risk of respiratory failure and death from SARS-CoV-2 infection. BMI is imprecise and fails to account for adipose tissue distribution. We sought to determine whether pericardial adipose tissue (PAT), abdominal visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), or hepatic adipose deposition on pre-pandemic computed...
Beyond Bias and Variance: Toward an Asymptotic Epistemology of Embodied Inference
This paper addresses a fundamental tension in contemporary epistemology: how finite cognitive agents achieve reliable knowledge despite operating under severe informational constraints. Drawing from the statistical learning concept of the bias-variance tradeoff, I argue that human epistemic success depends not on minimizing error through optimal model selection, but on achieving...
Plasma fatty acid composition modifies the cardiovascular risk of long-term PM2.5 exposure: a prospective cohort study of 428,048 participants
Background This study aimed to investigate whether plasma fatty acid composition is associated with incident atherosclerotic cardiovascular disease (ASCVD) and whether it modifies the cardiovascular risk associated with long-term exposure to fine particulate matter (PM2.5). Methods This prospective cohort study included 428,048 UK Biobank participants free of ASCVD at baseline...
Midrash Therapy as a Jewish Culturally Attuned Narrative Practice: Implications for Pastoral Counseling, Chaplaincy, and Spiritually Integrated Psychotherapy
Pastoral counseling, chaplaincy, and spiritually integrated psychotherapy increasingly emphasize culturally responsive approaches to meaning-making that attend to clients’ spiritual traditions without imposing theological authority. For some Jewish clients, spiritual and cultural meaning-making is shaped by interpretive practices that are dialogical, multivocal, and often text...
Observational study on the comparability of the clinical profiles of older adults with hip fractures and pelvic fractures in Germany
Background/objective Orthogeriatric co-management (OGCM) significantly improves outcomes in older adults with hip fractures; however, it remains unclear whether older adults with pelvic fractures can similarly benefit. This study aimed to compare clinical and geriatric profiles of older adults with hip fractures and pelvic fractures across relevant medical and geriatric domains...
Proof-of-concept engineering of Escherichia coli expressing a bee-derived cytochrome P450 monooxygenase for thiamethoxam detoxification
Bees are unintentionally exposed to pesticides applied to control other insect pests. Although bees possess endogenous detoxification mechanisms, their efficiency may not always be sufficient. To this end, the use of probiotics that can assist in pesticide detoxification may offer an additional layer of protection. In this study, we engineered Escherichia coli BL21(DE3) to...
Systematic analysis of the mitophagy scoring system in the prognosis and immunotherapy of HCC patients
Background Mitophagy plays a vital role in hepatocellular carcinoma (HCC) progression. This study aims to construct a mitophagy-related scoring system and evaluate its prognostic value, association with tumor immune activity, and gene mutation profiles in HCC patients, thereby advancing personalized diagnosis and treatment. Methods Copy number variation (CNV) data of mitophagy...
ABCA1-mediated lipid efflux restrains oxidative stress and neuroinflammation after spinal cord injury
Spinal cord injury (SCI) triggers a persistent inflammatory microenvironment that contributes to secondary tissue damage and neurological dysfunction. However, the metabolic mechanisms sustaining activation of lesion-associated phagocytes remain incompletely understood. Here, we identify lipid-laden microglia/macrophages as a metabolically stressed inflammatory state that emerges...