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Differences in isotretinoin start, interruption, and early termination across race and sex in the iPLEDGE era

Background iPLEDGE is the mandatory regulatory program for isotretinoin in the United States, aimed to prevent isotretinoin-related teratogenicity. However, little is known about potential unintended impact of the program, including delay in isotretinoin initiation, course interruption, and premature termination, which may vary across sex and racial domains. Objective To...

Evaluation of a professional social skills program for unemployed people with physical disability

The literature on labor points out the importance of social skills for employability. This study analyses, on a multiple probe design with two separate groups, the efficiency and effectiveness of a Professional Social Skills Training Program designed for unemployed people with physical disabilities. The sample consisted of 16 people with physical disabilities, aged from 18 to 36...

Prognostic Role of microRNA-155 in Various Carcinomas: Results from a Meta-Analysis

BACKGROUND: Recent studies have shown that microRNAs (miRNA) have prognostic values in cancers. This meta-analysis seeks to summarize the global predicting role of miR-155 for survival in patients with a variety of carcinomas.

The three-spined stickleback as a model for behavioural neuroscience

The three-spined stickleback (Gasterosteus aculeatus) is a small teleost fish that is ubiquitous across the Northern Hemisphere. Among the behaviours that have been characterised in this species is ritualized courtship, aggressiveness and parental behaviour. Whereas three-spined sticklebacks have been used for ecological, evolutionary, parasitological and toxicological research...

Translation invariance and finite additivity in a probability measure on the natural numbers

Inspired by the “two envelopes exchange paradox,” a finitely additive probability measure m on the natural numbers is introduced. The measure is uniform in the sense that m({i})=m({j}) for all i,j∈ℕ. The measure is shown to be translation invariant and has such desirable properties as m({i∈ℕ|i≡0(mod2)})=1/2. For any r∈[0,1], a set A is constructed such that m(A)=r; however, m is...

Elusive microbe that consumes ethane found under the sea

A microorganism that consumes ethane in the absence of environmental oxygen has been discovered. In the depths of the sea, this microbe, which oxidizes ethane, partners with another that reduces sulfate to sulfide.

Clinical and Molecular Characterization of Adult Glioblastomas in Southern Brazil

We investigated 113 adult Brazilian patients with glioblastoma (GBM) for comparison with patients from distinct geographical areas and evaluation of suitability for novel targeted therapies. Patients were assessed for clinical features and tumor genomic characteristics such as ROS1 and NTRK1 rearrangements, KIT, PDGFRA, and KDR amplification, and RB1 deletion using multicolor...

A proposal for a self-rated frailty index and status for patient-oriented research

ObjectiveFrailty indices are important predictors of major health outcomes, but mostly designed by and for researchers and specialists. Three of the most commonly used theory-based indices are composite measures that are subject to arbitrary assumptions and biases introduced due to data processing. A complicated index can be simplified with fewer items. The theory-based frailty...

Tour d'horizon des mouches des fruits impliquées dans la production fruitière sur la côte du Monténégro

Description du sujet. Les mouches des fruits représentent un grand groupe de ravageurs qui appartiennent à l'ordre des Diptères. La famille des Tephritidae (les vraies mouches des fruits) est l'une des deux familles de mouches appelées mouches des fruits. Elle appartient à l'une des plus importantes familles et au groupe de ravageurs agricoles les plus destructeurs au monde qui s...

Markers of Inflammation and Risk of Coronary Heart Disease

Cardiovascular disease is the leading cause of global mortality, with coronary heart disease (CHD) its major manifestation. Although inflammation, the body’s response to noxious stimuli, is implicated in several stages of CHD development, the relevance of circulating levels of markers of inflammation to CHD risk remains uncertain. This review summarizes available epidemiological...

Renal Urologic Anomalies Presenting In Adult Identical Twins

Two sets of identical adult twins recently presented to our hospital. In one case, the patients demonstrated (ipsilateral) renal agenesis. In the other, the patients presented approximately one year apart with symptomatic (ipsilateral) ureteropelvic junction obstructions. Although the literature suggests a few reports of this type in the pediatric and newborn population, the...

Treating Stress-Related Pain with the Flotation Restricted Environmental Stimulation Technique: Are There Differences between Women and Men?

The aim of the present study was to explore, for the first time, sex differences among patients diagnosed with stress-related pain before and after flotation restricted environmental stimulation technique (REST) treatment, delivered 12 times during seven weeks. The present study included 88 patients (69 women, 19 men) from three different studies (post hoc analysis). They had...

Characteristics of mental health recovery narratives: Systematic review and narrative synthesis

Background Narratives of recovery from mental health distress have played a central role in the establishment of the recovery paradigm within mental health policy and practice. As use of recovery narratives increases within services, it is critical to understand how they have been characterised, and what may be missing from their characterisation thus far. The aim of this review...

Early postnatal development of pyramidal neurons across layers of the mouse medial prefrontal cortex

Mammalian neocortex is a highly layered structure. Each layer is populated by distinct subtypes of principal cells that are born at different times during development. While the differences between principal cells across layers have been extensively studied, it is not known how the developmental profiles of neurons in different layers compare. Here, we provide a detailed...

Towards maximized utilization of iridium for the acidic oxygen evolution reaction

The reduction in noble metal content for efficient oxygen evolution catalysis is a crucial aspect towards the large scale commercialisation of polymer electrolyte membrane electrolyzers. Since catalytic stability and activity are inversely related, long service lifetime still demands large amounts of low-abundant and expensive iridium. In this manuscript we elaborate on the...

Continuity of Procambium and Anomalous Cambium During Formation of Successive Cambia in Celosia argentea

The development of woody plants is related to the continuity of the procambium and cambium. Whether such a continuity is present in plants with successive cambia, especially in those, where the first cambium is formed outside the primary vascular bundles, has not been analyzed so far. Therefore, we studied the development of vascular meristem in Celosia argentea, in which the...

The Transcribed-Ultraconserved Regions: A Novel Class of Long Noncoding RNAs Involved in Cancer Susceptibility

During recent years, novel approaches and new technologies have revealed a startling level of complexity of higher eukaryotes

A new species of sardine, Sardinella pacifica from the Philippines (Teleostei, Clupeiformes, Clupeidae)

A new sardine, Sardinella pacifica sp. n., is described on the basis of 21 specimens collected from the Philippines. The new species closely resembles Sardinella fimbriata (Valenciennes, 1847), both species having lateral scales with centrally discontinuous striae, a dark spot on the dorsal-fin origin, more than 70 lower gill rakers on the first gill arch, the pelvic fin with...

The Leibholz-Schmitt connection's formative influence on Bonhoeffer's 1932-33 entry into public theology

Dietrich Bonhoeffer's brother-in-law Gerhard Leibholz's insight into the Fascist theory of the state's messianic leadership and myth of creating communal life became a major source of information for Bonhoeffer. Leibholz had gained this knowledge in close jurisprudential cooperation with Carl Schmitt as is evidenced by Leibholz's 1929 habilitation thesis which at the same time...

Investigation into the Molecular Mechanisms underlying the Anti-proliferative and Anti-tumorigenesis activities of Diosmetin against HCT-116 Human Colorectal Cancer

Diosmetin (Dis) is a bioflavonoid with cytotoxicity properties against variety of cancer cells including hepatocarcinoma, breast and colorectal (CRC) cancer. The exact mechanism by which Dis acts against CRC however, still remains unclear, hence in this study, we investigated the possible molecular mechanisms of Dis in CRC cell line, HCT-116. Here, we monitored the viability of...

Organismes réglementés non de quarantaine : vers une plus large et meilleure application de ce concept international dans la région OEPP

Description du sujet. Les mesures définies sur les organismes réglementés non de quarantaine (ORNQ) visent à éviter un impact économique inacceptable suite à leur présence sur les végétaux destinés à la plantation et ce, bien que ces organismes nuisibles soient déjà présents dans la zone. Ainsi, contrairement aux organismes de quarantaine, le risque d'introduction des ORNQ n'est...

Resilience–throughput–power trade-off in future 5G photonic networks

5G New Radio allows operators to use new and wider spectrum and complements Long-Term Evolution networks with higher data rates and lower latency. Supporting such requirements in the transport network is not only a technological challenge, but a financial one as well. The use of high-frequency or unlicensed spectrum and cell densification for capacity increases call for adoption...

Entire surfaces of constant curvature in Minkowski 3-space

This paper concerns the global theory of properly embedded spacelike surfaces in three-dimensional Minkowski space in relation to their Gaussian curvature. We prove that every regular domain which is not a wedge is uniquely foliated by properly embedded convex surfaces of constant Gaussian curvature. This is a consequence of our classification of surfaces with bounded prescribed...

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