Welcome to Paperity
The first multidisciplinary aggregator of Open Access journals and papers. Keep on top of recent discoveries and never hit a paywall.
Recently added
S100A10-ANXA2 tetramer inhibition hampers hepatic stellate cell activation in human MASLD organoids
Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD), initiated by the pathological lipid accumulation within hepatocytes, can progress towards Metabolic dysfunction-Associated SteatoHepatitis (MASH) characterized by inflammation and fibrosis. Hepatic fibrosis is the strongest predictor of liver-related mortality, yet effective antifibrotic therapies remain limited...
Loss of systemic anti-viral immunity and LMP1-driven suppressive myeloid tumour niches converge to shape the immunobiology of Epstein-Barr virus-positive diffuse large B-cell lymphoma
Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (EBV⁺DLBCL) is an aggressive lymphoma with poor outcomes and an incompletely understood pathogenesis, frequently attributed to immunosenescence. However, its occurrence across all age groups suggests alternative mechanisms. Here, we integrate functional profiling of peripheral antiviral T-cell immunity with high...
Micro-TESE in men with non-obstructive azoospermia: a narrative review of sperm retrieval benefit, testicular injury, and endocrine risk
Background Microdissection testicular sperm extraction (micro-TESE) is an important treatment option for men with non-obstructive azoospermia (NOA) because it can provide sperm for intracytoplasmic sperm injection when other routes to biological fatherhood are unavailable. Counseling, however, should include not only the probability of sperm retrieval but also postoperative...
From Lived Experience to the Policy Table: Reimagining Child Welfare Through Peer Recovery Specialists
Parental substance use is a central driver of child welfare system involvement in the United States, yet child welfare policy often operates in tension with recovery-oriented approaches to substance use. This commentary argues that integrating lived experience into child welfare policymaking is both an ethical imperative and a pragmatic strategy for improving policy alignment...
Strain-rate-dependent compressive behaviour and constitutive modelling of circular WAAM ER70S-6 steel walls
Circular collars and wall-type components fabricated using wire-arc additive manufacturing (WAAM) are increasingly being considered for load-bearing steel applications. However, detailed compressive properties and constitutive models are limited. In this study, a circular ER70S-6 steel wall of five layers deposited on the SS400 substrate by WAAM was explored to understand the...
THE EFFECT OF CAPITAL EXPENDITURE ON RETURN ON EQUITY: DUPONT APPROACH ANALYSIS
This study examines the effect of CapEx on ROE using the DuPont Analysis framework and investigates the mediating roles of NPM, TAT and EM in this relationship. The study employs a quantitative approach using panel data from seven companies over the 2020-2024 period, yielding 35 observations. Data are analyzed using panel data regression with Fixed Effect and Random Effect Models...
Determinants of workplace violence against nurses and mitigation strategies in hospitals in developing countries: a scoping review
Background Violence against nurses has become a serious concern, especially in developing countries. Given the critical role that nurses play in healthcare, it is essential to implement interventions aimed at reducing this violence. The objective of this study was to identify the causes of violence against nurses in hospitals in developing countries and to propose mitigation...
Widening access, closing minds? The paradox of career aspiration and graduate employability in South Africa
In the global context of higher education massification and the shifting demands of the labour market, understanding the drivers of student career aspirations is critical. This study interrogates the “graduateness paradox” in South Africa—where expanded access has not yet yielded equitable employment outcomes—by moving beyond simplistic “skills gap” narratives. Employing Pierre...
Green valorization of melon and prickly pear byproducts for functional use in minced beef
Upcycling agro-waste in sustainable meat preservation supports clean-label standards and SDG12. Herein, we explore an eco-friendly preservation strategy of minced beef which extends product shelf-life and ensures microbial, physicochemical, and sensory integrity. Green extraction methodology of prickly pear peel (PP), melon peel (MP), and melon seeds showed superior greenness and...
Developing a mobile RNA delivery system for grafting trait improvement
Systemic RNA movement offers a route for non-transgenic trait improvement by grafting, but progress has been limited by the lack of reliable tools to identify mobile RNA elements. Here, we report a fluorescence-aptamer-based live-imaging platform for screening mobile RNAs and mapping mobility elements. In a transient screening assay, live imaging of 100 RNA-seq-predicted...
Long-range mutual activation establishes Rho and Rac polarity during cell migration
In migrating cells, the GTPase Rac organizes a protrusive front, whereas Rho organizes a contractile back. How these GTPases are positioned at opposite poles remains unclear. We leverage optogenetics, mechanical perturbations, and mathematical modelling to reveal a surprising mechanochemical long-range mutual activation between front and back polarity programmes that complements...
Homogenization in one-dimensional higher-order non-local models of phase transitions
We study the limit behavior of Cahn–Hilliard-type functionals in which the derivative is replaced by higher-order fractional derivatives and modulated by an oscillating factor. Depending on the ratio between the oscillation scale and the interface length, we identify three different regimes and prove \(\Gamma \)-convergence in each regime to a suitable sharp-interface limit...
Acid-phase protection of carbon steel by lauramidopropyl amine oxide: evidenced by ICP-AES, electrochemical methods, severe-condition testing, and atomistic modeling
The corrosion-inhibition performance of commercial lauramidopropyl amine oxide (LAO) toward carbon steel in 0.5 M HCl was evaluated through a combined experimental and computational workflow. Dissolved metal release was quantified by ICP-AES, while potentiodynamic polarization (PDP), electrochemical impedance spectroscopy (EIS), and linear polarization resistance (LPR) were used...
Assessing the social acceptability of sufficiency measures in the residential sector
Efficiency measures are insufficient for achieving greenhouse gas neutrality in the residential sector. Additional efforts are needed, with the concept of sufficiency gaining increasing attention. Sufficiency targets demand side and behavioural change, while delivering wellbeing. Reducing living space per capita is a sufficiency measure often suggested for residential buildings...
The normative structure of imperfection
Many philosophers have attempted to draw a distinction between perfect and imperfect duties. Roughly, imperfect duties are supposed to be obligations that allow for latitude, or room for choice, in complying with them. Beneficence is typically given as the paradigm example. Examples of perfect duties include our obligations not to harm others, and our obligations to keep promises...
GluD1 is localized at cholinergic synapses and is an acetylcholine receptor
The GluD1 receptor has many unusual features including expression at both excitatory and inhibitory synapses and a ligand binding domain capable of binding both D-serine and GABA. We have previously demonstrated that striatal GluD1 is critical for the regulation of behavioral flexibility, a phenotype dependent on the cholinergic system. Here, we found that GluD1 is enriched...
OpenCSP: a deep learning framework for crystal structure prediction from ambient to high pressure
High-pressure crystal structure prediction (CSP) underpins advances in condensed matter physics, planetary science, and materials discovery. However, most large atomistic models are trained on near-ambient equilibrium data, which leads to reduced stress accuracy at tens to hundreds of gigapascals and limited coverage of pressure-stabilized stoichiometries and dense coordination...
An improved multi-objective optimization approach for workstation paralleling and machine selection in miniature circuit breaker assembly lines
Workstation paralleling is a feasible approach to optimize the configuration scheme of miniature circuit breaker assembly lines (MCBALs) for reducing equipment cost and improving production efficiency. However, the traditional workstation paralleling approaches rarely consider machine selection, which limits the optimization potential of assembly line configurations...
PENGARUH PERSEPSI MANFAAT, KEMUDAHAN, DAN KEPERCAYAAN TERHADAP MINAT PENGGUNAAN APLIKASI KEUANGAN BERBASIS SELULER PADA UMKM DI KABUPATEN MOJOKERTO
The development of information technology has encouraged Micro, Small, and Medium Enterprises (MSMEs) to utilize mobile-based financial applications in managing their businesses. However, the interest in using financial applications among MSMEs is still influenced by several factors, such as perceived usefulness, ease of use, and user trust in the applications. This study aims to...
Effects of Di(2-ethylhexyl) phthalate (DEHP) and hyperoxia on cardiovascular development in newborn rats
BackgroundPreterm infants encounter DEHP through medical devices and equipment. While hyperoxia is known to promote cardiac remodeling and dysfunction, the impact of early phthalate exposure is understudied. We hypothesized that independent and combined DEHP and hyperoxia exposure would impair neonatal cardiovascular development.MethodsNewborn rats were exposed from birth to day...
Barriers to home-based self-management in hospitalized patients with type 2 diabetes: a qualitative descriptive content analysis guided by protection motivation theory
Background Effective self-management is essential for glycemic control in type 2 diabetes. However, many patients experience self-management failure prior to hospitalization. This study aimed to explore the barriers to home-based self-management among hospitalized Chinese patients and interpret these barriers using Protection Motivation Theory (PMT). Methods A descriptive...
Predicting orchiectomy in testicular torsion using hybrid machine learning and explainable AI: a web-based clinical decision support system
Objective To develop a high-accuracy prediction model using hybrid machine learning (ML) and explainable artificial intelligence (XAI) techniques for distinguishing between orchiectomy and detorsion in testicular torsion (TT), and to create an interactive web application and nomogram for clinical use. Materials and methods Data from 117 patients who underwent surgical treatment...
Baseline state for pulmonary vasculature with pulmonary arterial hypertension: effect of geometric remodeling and metabolic shift
Pulmonary arterial hypertension (PAH) is a complex disease characterized by chronically elevated pulmonary arterial pressure, with early onset and progression linked to structural, metabolic, and morphological changes in the pulmonary vasculature. Understanding the interplay between hemodynamics and arterial wall mechanics is essential to capture the pathology of the distal...
Associations of plasma metabolites with protein biomarkers linked to Alzheimer’s disease pathology in the Rotterdam Study
Background Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder characterized by amyloid-β (Aβ) and tau pathology, neuroaxonal damage, and neuroinflammation. While blood biomarkers, such as tau, neurofilament light chain (NfL), and Aβ isoforms, reflect AD pathology, the systemic metabolic alterations contributing to the disease remain poorly defined. This study...
Pendidikan Multikultural berbasis Kearifan Lokal untuk menumbuhkan Karakter Toleransi
Penelitian bertujuan untuk menganalisis internalisasi pendidikan multikultural serta faktor pendukung dan penghambatnya berbasis kearifan lokal. Pendekatan kualitatif dengan jenis studi kasus digunakan, melibatkan guru, kepala sekolah, dan siswa. Data dikumpulkan melalui wawancara, observasi, dan dokumentasi, dan dianalisis dengan teknik triangulasi. Temuan pertama, internalisasi...
Self-powered and highly stable broadband photodetectors based on spin-coated PbWO4/Si heterostructures with 720-day environmental robustness
Lead Tungstate (PbWO4) has been extensively utilized as a high-performance scintillator in high-energy physics due to its superior radiation hardness and fast response time. However, its potential for direct, high-performance photodetection has remained largely untapped. This work bridges this gap by demonstrating, for the first time, a high-sensitivity broadband photodetector...
Immunological links between aplastic anemia and paroxysmal nocturnal hemoglobinuria
Aplastic anemia (AA) and paroxysmal nocturnal hemoglobinuria (PNH) are closely related bone marrow (BM) failure syndromes linked by shared immunological mechanisms. The frequent emergence of PNH-type blood cells during AA, together with the co-occurrence of the disorders and their overlapping therapeutic responses, supports the concept that they represent a spectrum of immune...