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Exploiting macro- and micro-structural brain changes for improved Parkinson’s disease classification from MRI data

Parkinson’s disease (PD) is the second most common neurodegenerative disease. Accurate PD diagnosis is crucial for effective treatment and prognosis but can be challenging, especially at early disease stages. This study aimed to develop and evaluate an explainable deep learning model for PD classification from multimodal neuroimaging data. The model was trained using one of the...

Mixed tin-lead perovskites with balanced crystallization and oxidation barrier for all-perovskite tandem solar cells

Mixed tin-lead perovskite solar cells have driven a lot of passion for research because of their vital role in all-perovskite tandem solar cells, which hold the potential for achieving higher efficiencies compared to single-junction counterparts. However, the pronounced disparity in crystallization processes between tin-based perovskites and lead-based perovskites, coupled with...

Multi-night cortico-basal recordings reveal mechanisms of NREM slow-wave suppression and spontaneous awakenings in Parkinson’s disease

Sleep disturbance is a prevalent and disabling comorbidity in Parkinson’s disease (PD). We performed multi-night (n = 57) at-home intracranial recordings from electrocorticography and subcortical electrodes using sensing-enabled Deep Brain Stimulation (DBS), paired with portable polysomnography in four PD participants and one with cervical dystonia (clinical trial: NCT03582891...

Fabrication of porous beta-cyclodextrin functionalized PVDF/Fe–MOF mixed matrix membrane for enhanced ciprofloxacin removal

Herein, we demonstrate the synthesis of beta-cyclodextrin (β–CD) functionalized polyvinylidene fluoride (PVDF) and iron-based metal-organic framework (Fe–MOF) mixed matrix membrane (MMM) for the enhanced removal of ciprofloxacin (CIP) from water. The membranes were prepared using the phase inversion technique with PVDF as the polymer matrix, Fe–MOF as the filler, and...

Prolactin Mediates Long-Term, Seasonal Rheostatic Regulation of Body Mass in Female Mammals

A series of well-described anabolic and catabolic neuropeptides are known to provide short-term, homeostatic control of energy balance. The mechanisms that govern long-term, rheostatic control of regulated changes in energy balance are less well characterized. Using the robust and repeatable seasonal changes in body mass observed in Siberian hamsters, this report examined the...

Effective lung nodule detection using deep CNN with dual attention mechanisms

Novel methods are required to enhance lung cancer detection, which has overtaken other cancer-related causes of death as the major cause of cancer-related mortality. Radiologists have long-standing methods for locating lung nodules in patients with lung cancer, such as computed tomography (CT) scans. Radiologists must manually review a significant amount of CT scan pictures...

Physics guided heat source for quantitative prediction of IN718 laser additive manufacturing processes

Challenge 3 of the 2022 NIST additive manufacturing benchmark (AM Bench) experiments asked modelers to submit predictions for solid cooling rate, liquid cooling rate, time above melt, and melt pool geometry for single and multiple track laser powder bed fusion process using moving lasers. An in-house developed Additive Manufacturing Computational Fluid Dynamics code (AM-CFD...

Optically addressable spin defects coupled to bound states in the continuum metasurfaces

Van der Waals (vdW) materials, including hexagonal boron nitride (hBN), are layered crystalline solids with appealing properties for investigating light-matter interactions at the nanoscale. hBN has emerged as a versatile building block for nanophotonic structures, and the recent identification of native optically addressable spin defects has opened up exciting possibilities in...

PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development

Proper placental development in early pregnancy ensures a positive outcome later on. The developmental relationship between the placenta and embryonic organs, such as the heart, is crucial for a normal pregnancy. However, the mechanism through which the placenta influences the development of embryonic organs remains unclear. Trophoblasts fuse to form multinucleated...

ScLinear predicts protein abundance at single-cell resolution

Single-cell multi-omics have transformed biomedical research and present exciting machine learning opportunities. We present scLinear, a linear regression-based approach that predicts single-cell protein abundance based on RNA expression. ScLinear is vastly more efficient than state-of-the-art methodologies, without compromising its accuracy. ScLinear is interpretable and...

An assessment of traffic education and its examination system—an extended House of Quality approach

The goal of this article is to examine traffic education and its examination system, using a new approach based on the House of Quality method. While every country has its own legal rules and requirements regarding how traffic education and examinations are conducted, there is a direct relationship between traffic education, its examination system and road safety. Therefore the...

A druggable conformational switch in the c-MYC transactivation domain

The c-MYC oncogene is activated in over 70% of all human cancers. The intrinsic disorder of the c-MYC transcription factor facilitates molecular interactions that regulate numerous biological pathways, but severely limits efforts to target its function for cancer therapy. Here, we use a reductionist strategy to characterize the dynamic and structural heterogeneity of the c-MYC...

Robotic monitoring of dunes: a dataset from the EU habitats 2110 and 2120 in Sardinia (Italy)

This data descriptor presents a novel dataset collected using the quadrupedal robot ANYmal C in the Mediterranean coastal dune environment of the European Union (EU) habitats 2110 and 2120 in Sardinia, Italy. The dataset mainly consists of photos, videos, and point clouds of the coastal dunes, providing valuable information on the structure and composition of this habitat. The...

Numerical evaluation of sweeping gas membrane distillation for desalination of water towards water sustainability and environmental protection

Sweeping gas membrane distillation (SGMD) is considered a membrane distillation configuration. It uses an air stream to collect the water vapour. A 2D mathematical model is prepared in the current study to predict the effect of various operating parameters on the SGMD performance. Also, the temperature distribution in the SGMD was obtained. The effect of air inlet temperature...

µ-Opioid receptor antagonism facilitates the anxiolytic-like effect of oxytocin in mice

Mood and anxiety disorders are leading causes of disability worldwide and are major contributors to the global burden of diseases. Neuropeptides, such as oxytocin and opioid peptides, are important for emotion regulation. Previous studies have demonstrated that oxytocin reduced depression- and anxiety-like behavior in male and female mice, and opioid receptor activation reduced...

Non-native ants are breaking down biogeographic boundaries and homogenizing community assemblages

As geographic distance increases, species assemblages become more distinct, defining global biogeographic realms with abrupt biogeographic boundaries. Yet, it remains largely unknown to what extent these realms may change because of human-mediated dispersal of species. Focusing on the distributions of 309 non-native ant species, we show that historical biogeographic patterns have...

Observation of nonvolatile magneto-thermal switching in superconductors

Applying a magnetic field to a solid changes its thermal-transport properties. Although such magneto-thermal-transport phenomena are usually small effects, giant magneto-thermal resistance has recently been observed in spintronic materials and superconductors, opening up new possibilities in thermal management technologies. However, the thermal conductivity conventionally changes...

Dissemination of Circulating Tumor Cells in Breast and Prostate Cancer: Implications for Early Detection

Burgeoning evidence suggests that circulating tumor cells (CTCs) may disseminate into blood vessels at an early stage, seeding metastases in various cancers such as breast and prostate cancer. Simultaneously, the early-stage CTCs that settle in metastatic sites [termed disseminated tumor cells (DTCs)] can enter dormancy, marking a potential source of late recurrence and therapy...

Nonpathogenic Pseudomonas syringae derivatives and its metabolites trigger the plant “cry for help” response to assemble disease suppressing and growth promoting rhizomicrobiome

Plants are capable of assembling beneficial rhizomicrobiomes through a “cry for help” mechanism upon pathogen infestation; however, it remains unknown whether we can use nonpathogenic strains to induce plants to assemble a rhizomicrobiome against pathogen invasion. Here, we used a series of derivatives of Pseudomonas syringae pv. tomato DC3000 to elicit different levels of the...

Immunoinformatics and computational approaches driven designing a novel vaccine candidate against Powassan virus

Powassan virus (POWV) is an arthropod-borne virus (arbovirus) capable of causing severe illness in humans for severe neurological complications, and its incidence has been on the rise in recent years due to climate change, posing a growing public health concern. Currently, no vaccines to prevent or medicines to treat POWV disease, emphasizing the urgent need for effective...

Safety of female ride-hailing passengers: Perception and prevention

Ride-hailing, as part of wider transitions to smart city, has emerged as a beneficial complement to urban public transport. However, the frequent occurrence of ride-hailing safety accidents in multiple countries has raised concerns about passenger safety on an international scale. Within this context, this study aims to investigate female passengers’ safety perception and...

Ultra-compact exciton polariton modulator based on van der Waals semiconductors

With the rapid emergence of artificial intelligence (AI) technology and the exponential growth in data generation, there is an increasing demand for high-performance and highly integratable optical modulators. In this work, we present an ultra-compact exciton-polariton Mach–Zehnder (MZ) modulator based on WS2 multilayers. The guided exciton-polariton modes arise in an ultrathin...

Controlled dissolution of a single ion from a salt interface

Interactions between monatomic ions and water molecules are fundamental to understanding the hydration of complex polyatomic ions and ionic process. Among the simplest and well-established ion-related reactions is dissolution of salt in water, which is an endothermic process requiring an increase in entropy. Extensive efforts have been made to date; however, most studies at...

A Wnt10a-Notch signaling axis controls Hertwig’s epithelial root sheath cell behaviors during root furcation patterning

Human with bi-allelic WNT10A mutations and epithelial Wnt10a knockout mice present enlarged pulp chamber and apical displacement of the root furcation of multi-rooted teeth, known as taurodontism; thus, indicating the critical role of Wnt10a in tooth root morphogenesis. However, the endogenous mechanism by which epithelial Wnt10a regulates Hertwig’s epithelial root sheath (HERS...

Antibody and antibody fragments site-specific conjugation using new Q-tag substrate of bacterial transglutaminase

During the last few years Antibody-Drug Conjugates (ADCs) have become one of the most active and very promising therapeutic weapons. Lessons learned from the traditional chemical conjugations (via lysine or cysteine residues of the antibodies) and the clinical studies of the developed ADCs have recently paved the way to the improvement of the conjugation technologies. Use of site...

3D culture of alginate-hyaluronic acid hydrogel supports the stemness of human mesenchymal stem cells

The three-dimensional (3D) cell culture system is being employed more frequently to investigate cell engineering and tissue repair due to its close mimicry of in vivo microenvironments. In this study, we developed natural biomaterials, including hyaluronic acid, alginate, and gelatin, to mimic the creation of a 3D human mesenchymal stem cell (hMSC) extracellular environment and...

Global evaluation of lineage-specific human papillomavirus capsid antigenicity using antibodies elicited by natural infection

Human Papillomavirus (HPV) type variants have been classified into lineages and sublineages based upon their whole genome sequence. Here we have examined the specificity of antibodies generated following natural infection with lineage variants of oncogenic types (HPV16, 18, 31, 33, 45, 52 and 58) by testing serum samples assembled from existing archives from women residing in...

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