Background Nuclear export mediator factor (NEMF) is considered to be a tumor suppressor in Drosophila. Based on the analysis of data from an online database, NEMF is downregulated in OV. However, the mechanism underlying its expression has not been reported thus far. Results In this study, the immunohistochemistry results showed that the expression of NEMF may be related to...
This study presents the design, synthesis, and comprehensive evaluation of a novel thiosemicarbazone derivative containing a pyrimidine-imidazole (C11H11N8SCl) as a potential BRAF inhibitor for the treatment of non-small cell lung cancer. The compound was synthesized by a condensation reaction and characterized by elemental analysis, molar conductivity, SEM-EDS, FT-IR, 1H, and...
Liver hepatocellular carcinoma (LIHC) is a heterogeneous malignancy with poor prognosis, but the landscape of cellular senescence-related genes (CSRGs) in LIHC remains incompletely characterized. Here, we curated 167 CSRGs and performed integrative bulk and single-cell RNA-seq analyses using TCGA, ICGC, and TISCH datasets. Fifteen prognostic CSRGs were identified and stratified...
Lung adenocarcinoma (LUAD) is the pathological type with the highest proportion and heterogeneity in lung cancer. NADPH oxidase is an important enzyme in the biological respiratory chain that plays a decisive role in cell growth, regulation, and apoptosis, which translating seven gene families, namely NOX1-5 and DUOX1-2. The current study aimed to investigate the expression, and...
Introduction Despite significant improvements in the overall survival of Wilms tumor (WT), a subset of patients still experiences poor outcomes. Programmed cell death (PCD) pathways are pivotal in cancer progression. A deeper understanding of their roles in WT is crucial for harnessing these mechanisms to optimize risk stratification. Methods Key tumor-associated genes were...
Background Rare pure histological breast cancer subtypes represent a clinically heterogeneous group of tumors with diverse biological behaviours and prognostic profiles. Due to their rarity, data, particularly regarding long-term survival outcomes, are limited and controversial. This study aimed to evaluate the clinicopathological features and long-term survival outcomes of...
Background To explore the correlation between cerebrospinal fluid (CSF) and peripheral blood cytokines and survival in patients with Leptomeningeal metastases (LM) of glioblastoma. Methods The study retrospectively included 35 patients with glioblastoma LM diagnosed from September 2022 to August 2024 at Beijing Tiantan Hospital. CSF and peripheral blood cytokines were collected...
Background Bladder urothelial carcinoma (BLCA) exhibits heterogeneous outcomes, creating an urgent need for reliable prognostic biomarkers. Glycosylation modifications are crucial in cancer but understudied for BLCA stratification. Methods Using clinical and transcriptomic data from The Cancer Genome Atlas (TCGA) and glycosylation-related genes from the Gene Set Enrichment...
Background Occult peritoneal metastasis (OPM) represents a type of distant metastasis that is often overlooked during the preoperative diagnosis of advanced gastric cancer (AGC). Methods We employed the negative enrichment combined with immunofluorescence in situ hybridization (imFISH) technique to detect the number of circulating tumor cells (CTC) in the peripheral blood of...
Objective To investigate the role of the ferroptosis-related gene EPAS1 in breast cancer progression and its impact on macrophage polarization. Methods Bioinformatics and machine learning approaches were employed to identify ferroptosis-related differentially expressed genes (DEGs) in breast cancer tissues. Functional enrichment analysis was subsequently performed to explore the...
State-of-the-art rodent models have aided researchers in the refinement of a holistic understanding of the mechanistic insights related to metastasis, which will eventually lead to the discovery of new multi-targeted therapeutic options. More recently, extraordinary breakthroughs in the genomics, proteomics and mouse modeling have significantly fostered a renaissance of cutting...
Background The association between lactylation and tumor radiotherapy has become a widely studied hotspot. However, the prognostic value of lactylation-related genes (LRGs) linked to radiotherapy‑associated transcriptional changes in cervical cancer remains unclear. Methods Based on gene expression data from public databases and LRGs, we identified key genes for cervical cancer...
Background Immune-related adverse events (irAEs) significantly impact the therapeutic efficacy of immune checkpoint inhibitors (ICIs) in lung cancer. However, a comprehensive understanding of the global research landscape and its evolution regarding irAEs is still lacking. Methods We conducted a bibliometric analysis of 6787 publications from the Web of Science Core Collection...
Background Ammonia, which was traditionally regarded as a metabolic by-product, has more recently emerged as a crucial regulator of tumor metabolism and immune dysfunction. Nevertheless, the prognostic implications and therapeutic significance of ammonia-related genes in colorectal cancer (CRC) are still largely uncharted territory. This lack of exploration means that there is a...
Background Hepatocellular carcinoma (HCC) poses a major global health challenge due to its high mortality and recurrence, necessitating continuous research into biomarkers for better diagnosis and treatment. Methods Gene expression and clinical data from HCC patients were sourced from TCGA, with the GSE14520 dataset used for validation. Differentially expressed genes (DEGs...
Cervical cancer (CC) remains a major global health challenge, largely driven by persistent infection with high-risk human papillomavirus (HPV) genotypes. Emerging evidence suggests that the interplay between HPV, the vaginal microbiota (VM), and host immune responses critically influences viral persistence and disease progression. In particular, dysbiotic VM marked by reduced...
Objective Cancer of unknown primary with brain metastases (CUP-BM) represents a distinct and challenging disease entity characterized by an extremely poor prognosis. Currently, there is a lack of systematic research on its prognostic factors. This study aimed to analyze the prognostic factors associated with CUP-BM. Methods Patients diagnosed with CUP-BM between 2010 and 2022...
Purpose Acute Myeloid Leukemia (AML) is driven by complex interactions between genetic mutations and epigenetic dysregulation. While alterations in chromatin modifiers are frequent, the precise downstream transcriptional networks they enable and how these networks execute the leukemogenic program remain incompletely defined. Methods We employed an integrative bioinformatics...
Breast cancer (BC) is a highly heterogeneous malignancy with a complex pathogenesis involving multiple molecular pathways and cellular interactions. The tumor microenvironment (TME) plays a crucial role in this process, but the functions of immune and stromal components within the TME remain to be further elucidated. This study aims to identify core genes associated with...
Background Breast cancer (BRCA) is the most common malignant tumor in women, with prognoses differing markedly by molecular subtype. Exercise is known to be related to tumor occurrence and progression, yet its role in BRCA remains understudied. This research seeks to explore the prognostic and immunomodulatory functions of exercise-related genes (ERGs) in BRCA, and their links to...
Artificial Intelligence (AI) is reshaping oncology by addressing key limitations in traditional cancer care and enabling data-driven, personalized approaches from diagnosis to treatment. This review explores the transformative role of AI across the cancer care continuum, highlighting its contributions, challenges, and future directions. AI has significantly advanced cancer...
Introduction. Hepatocellular carcinoma (HCC) exhibits profound molecular heterogeneity, which complicates prognosis and therapy. Identifying key molecular subtypes and their driving oncogenes is crucial for developing targeted strategies. This study aimed to delineate chemokine-based HCC subtypes and investigate the functional role and mechanism of a critical identified driver...
Purpose Prenatal ultrasound screening has increased detection of adrenal masses during the fetal and neonatal periods, creating management dilemmas between immediate surgical intervention and observation. This study evaluates the outcomes of selective conservative management in perinatal adrenal masses. Methods We conducted a single-institution retrospective case series of nine...
Background Guanylate binding protein 5 (GBP5) belongs to an interferon (IFN)-inducible subfamily of guanosine triphosphatases (GTPases). GBP5 has been shown to promote NLRP3 inflammasome assembly, thereby playing a key role in innate immunity and inflammation. However, the role of GBP5 in the development of various cancers and its potential as a biomarker in cancer prognosis are...
Cancer is a major global health issue, leading to high morbidity and mortality. This study investigates CALML6 expression and its clinical relevance across cancer types using RNA-sequencing data from public databases like UCSC Xena and TCGA, assessing mRNA levels, mutations, CNV, SNV, methylation, and drug sensitivity via GSCA and cBioPortal. Results show CALML6 is upregulated in...