Research question Which patients with endometriosis suffer from diminished ovarian reserve as well as impaired embryo quality and therefore could benefit from medical freezing as part of fertility preservation strategies? Design This retrospective study analyzed 205 patients who underwent follicle puncture at our center in preparation for IVF/ICSI treatment. All patients with...
Purpose Foetal growth restriction (FGR) complicates 5–10% of pregnancies and is a major contributor to perinatal morbidity and mortality. In late-onset FGR, induction of labour is recommended; however, intrapartum caesarean rates remain high (20–40%). Accurate counselling regarding the likelihood of vaginal delivery is essential, yet no validated prediction model exists for this...
The human placenta is a specialized fetomaternal organ whose architecture evolves throughout pregnancy. Its development begins with implantation, followed by the differentiation of trophoblast lineages that establish the early villous structures and mediate subsequent exchange between the maternal and fetal circulations. By the end of the second trimester, coordinated remodeling...
Purpose To estimate the burden of metabolic syndrome (MetS) on severe maternal morbidity (SMM) in women of advanced maternal age (AMA), quantify age-related escalation in SMM risk, and evaluate sociodemographic influences. Methods We retrospectively conducted a cross-sectional, population-level analysis of the Nationwide Inpatient Sample (Q4 2015–2019), a discharge-level database...
Objective To study the existing knowledge, interests, and attitudes of medical students regarding fertility preservation measures. Design A multi-center nationwide survey was conducted among medical students across Germany. The survey consisted of 15 multiple-choice questions and six questions asking participants their level of agreement of a statement. Subjects 346 medical...
Purpose Studies on vaginal natural orifice transluminal endoscopic surgery (vNOTES), which provides enhanced endoscopic vision via the vaginal route, are limited. Therefore, this study aimed to evaluate the feasibility, safety, and perioperative outcomes of vNOTES hysterectomy in symptomatic patients with giant polymyomatous uteri and no prior vaginal delivery. Methods A...
Purpose Lipedema is a chronic disorder that affects the subcutaneous adipose tissue of the lower and upper limbs and results in painful fat accumulations. During the reproductive life span, about 11% of women are affected; however, there are a high number of suspected undiagnosed and thus untreated cases. Methods The aim of this systematic review was to evaluate the association...
Purpose Polycystic ovary syndrome (PCOS) is associated with a broad range of reproductive, metabolic, and psychosocial symptoms. This study aimed to evaluate whether body mass index (BMI) and dysglycemia independently predict symptom burden and to explore how these factors relate to patient-perceived care gaps, as reflected by satisfaction with counselling. Methods We conducted a...
Objective To evaluate the impact of Pilates exercise during pregnancy on sleep quality, eating disorder symptoms, and occupational balance. Methods This cross-sectional observational comparative study included 120 pregnant women: a Pilates group (n = 60, age = 27.98 ± 3.99) and a non-Pilates group (n = 60, age = 28.90 ± 4.25). Sleep quality, disordered eating, and occupational...
Background Maternal ophthalmic artery Doppler assessment has been proposed as one of the predictors for preeclampsia at any given time. Changes in ophthalmic artery Doppler preceding the onset of PE have been reported in several studies. Some parameters of ophthalmic artery Doppler studies have been proposed, but peak systolic velocity ratio is the most reliable indicator in the...
Purpose This study examines whether the perinatal mortality rates (up to 7 days postpartum) of successful vaginal breech birth (VBB) align with those of vaginal cephalic birth (VCB) under the current practice of risk stratification and promotion of VBB in Germany. This study excludes births that did not result in vaginal breech birth, i.e., cases where a vaginal birth was...
Purpose To investigate the applicability and safety of the blastocyst grading system for borderline blastocysts assessed by measurement of the inner cell mass (ICM) and trophectoderm (TE) parameters. Methods A total of 361 borderline blastocysts were classified as B-B-, B-C, and CB/CB-blastocysts based on the parameters of the ICM and TE in frozen-thawed embryo transfer cycles...
This study aimed to compare the clinical pregnancy rates of hysterosalpingography (HSG) with water-based contrast and hysterosalpingo-contrast sonography (HyCoSy) to investigate their impact on fertility outcomes in women with endometriosis-related infertility. This retrospective study included 296 women with endometriosis-related infertility, aged 18–39, undergoing HSG or HyCoSy...
To compare the clinical outcomes of extremely poor responders with one or two oocytes who receive in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). A retrospective study was carried out on 2572 patients with one or two oocytes retrieved from 2013 to 2022, of which 2159 patients were scheduled to receive IVF treatment and 413 patients were scheduled to...
Gynecological oncology requires a high level of surgical expertise. Therefore, new options for realistic surgical training for complex surgical procedures are required. This study aimed to determine how the trainees and experts perceive the use of soft-embalmed cadavers and how realistic it is compared to training on living patients. A 2-day hands-on workshop was conducted. Eight...
The aim of this study is to investigate the differences in the accuracy of sonographic antenatal fetal weight estimation at term with artificial intelligence (AI) compared to that of clinical sonographers at different levels of experience. This is a prospective cohort study where pregnant women at term scheduled for an imminent elective cesarean section were recruited. Three...
In vitro fertilization occurs in a controlled laboratory setting, where oocytes are fertilized by sperm, and the resulting embryos are cultured to the blastocyst stage before transfer to the uterus. The secreted/consumed substances by the embryo in the extracellular environment (secretome) contain a variety of molecules that may provide insights into embryo quality. This study...
To evaluate the clinicopathologic characteristics and survival outcomes of ovarian clear cell carcinoma (OCCC) patients with different endometriosis statuses. This retrospective study included OCCC patients diagnosed between 2012 and 2021, classified into three groups based on the Sampson and Scott criteria: Without (no endometriosis), Arising (OCCC arising from endometriosis...
Intrapartum fever (IPF) (≥ 38.0 °C), if treated inappropriately, can lead to maternal bacteremia. In a cohort of women with IPF, we investigated perinatal, obstetrical, and microbiological outcomes, comparing those with bacteremia to those with negative blood cultures. A retrospective cohort study at a tertiary hospital (2010–2022) focused on women attempting vaginal delivery who...
Medical advancements in breast cancer are truly remarkable. Especially in recent years, numerous new therapeutics have been approved and surgical strategies have been de-escalated for specific patient groups. In the therapeutic setting, CDK4/6 inhibitors as oral maintenance therapy in early breast cancer and immune checkpoint inhibitors (Pembrolizumab) for triple-negative breast...
Research on menopause and eating behavior has mostly focused on women with premenopausal, perimenopausal, and natural postmenopausal stages. The aim of this study was to investigate eating behavior and body image in women with non-natural menopause. The sample included 330 postmenopausal women, classified as non-natural menopause (NNMP) (N = 103) due to gynecological surgery...
Gestational diabetes mellitus (GDM) affects 3%–25% of pregnancies worldwide, posing risks to maternal, fetal, and neonatal health. GDM is often associated with macrosomia and large-for-gestational-age (LGA) infants. However, the association between GDM and small-for-gestational-age (SGA) infants is less understood. This study aimed to identify predictors of SGA in women with GDM...
Endometriosis has a significant negative impact on women’s lives. Unfortunately, current medical treatments often fail to provide adequate pain relief and may cause intolerable side effects. Although many women experiencing primary dysmenorrhoea employ self-management strategies to help alleviate period-related symptoms, there is a paucity of knowledge about how women with...