Virtual reality (VR) based technology may offer new avenues in the management of chronic endometriosis-related pain. Our prospective, 14-week, open, three-phase, cross-over pilot study investigated whether the use of VR technology equipped with a relaxation-inducing application (VR-R) or an activity-stimulating application (VR-A) could change endometriosis-related chronic pelvic...
The aim of the present study was to quantify the rate of thromboembolic events (TE) in pregnant women with SARS-CoV-2 infection and to characterize risk factors to provide a basis for individualized recommendation on prophylactic measures. CRONOS is a multicenter, prospective observational study conducted in Germany and Austria during the COVID-19 pandemic. Pregnant women with...
To evaluate the effect of nitric oxide (NO) donor, in combination with plasma volume expansion, on both fetal and maternal outcomes in pregnancies complicated by early-onset fetal growth restriction (FGR). A total of 40 pregnant women diagnosed with early onset FGR were recruited from Ain Shams University Maternity Hospital between June 2023 to December 2023. The patients were...
A unicornuate uterus is a type of Müllerian anomaly and is associated with adverse pregnancy outcomes. However, the perinatal outcomes of twin pregnancies in women with a unicornuate uterus remain unknown, and previous studies on women with a unicornuate uterus have focused mostly on those with singleton pregnancies. This research aimed to investigate the perinatal outcomes of...
Review and compare current classifications for diagnosing T-shaped uterus using three-dimensional transvaginal ultrasound (3D-TVS) measurements, identifying measurements that best correlate with the diagnosis. This retrospective cohort study analyzed diagnostic measurements in patients with T-shaped uterus who underwent 3D-TVS at the University of Rome ‘Tor Vergata’ from 2016 to...
To explore the effects of autologous platelet-rich plasma (PRP) intrauterine perfusion on clinical outcomes in recurrent implantation failure (RIF) patients with non-thin endometrium undergoing frozen-thawed embryo transfer (FET), and the effects of PRP used at different times before FET on clinical outcomes. A total of 160 RIF patients with non-thin endometrium undergoing FET...
Stillbirth is a public health problem and one of the main obstetrical complications of pregnancy that practitioners can ever witness. A careful etiological investigation and a search for risk factors is necessary. The main objective of our study was to identify the causes of stillbirths using the CODAC classification system. It was a monocentric retrospective descriptive study...
To explore factors related to dysmenorrhea in adenomyosis and construct a risk prediction model. A cross-sectional survey involving 1636 adenomyosis patients from 37 hospitals nationwide (November 2019–February 2022) was conducted. Data on demographics, disease history, menstrual and reproductive history, and treatment history was collected.Patients were categorized into...
To determine the healthy lifestyle behaviors (HLBs) and gynecological cancer awareness (GCA) levels of women academicians and to investigate the correlation between HLBs and GCA. A descriptive correlational study design was used to determine the healthy life behaviors and gynecological cancer awareness levels of women academicians and to investigate the correlation between them...
The association between inherited thrombophilias and stillbirth has been long investigated but the estimated risk remains unknown. The aim of our study is to summarize available data on the effect of Factor V Leiden, Prothrombin G20210A and MTHFR mutation, Protein S, Protein C and Anithrombin deficiency on the prevalence of stillbirth. We conducted a systematic review and meta...
To describe the microbiome of the vagina and fallopian tubes (FT) and its relation with hydrosalpinx. Case–control study was conducted in women who underwent salpingectomy for hydrosalpinx (case) or other indications (controls). Samples were obtained during surgery and subjected to 16S rRNA amplicon sequencing, and analyses of alpha diversity and beta diversity measures were...
Induction of labor as well as delivery in twin pregnancies bears specific risks. The goal of this study was to analyze the delivery mode in twin pregnancies and influence of induction on the cesarean delivery (CD) rate and perinatal outcome and to identify risk factors for CD and an intertwin interval ≥ 15 min. This single-center retrospective cohort study analyzed the outcome of...
Homologous recombination deficiency (HRD) is a key biomarker in the management of high-grade serous ovarian cancer (HGSOC), guiding treatment decisions, particularly regarding the use of poly(ADP-ribose) polymerase inhibitors (PARPi). As multiple HRD assays are available, each with distinct methodologies and cutoff values, the interpretation and clinical application of HRD...
Prenatal severe Ebstein anomaly might be complicated by a circular shunt. In these cases, persistently elevated right atrial and venous pressure (due to severe tricuspid regurgitation) is complicated by a systemic ineffective blood shunt via a DA, resulting in diminished end-organ perfusion and acidosis, due to overall low cardiac output. Affected fetuses are at a significantly...
We aimed to conduct a systematic review and meta-analysis comparing the outcomes of subdermal implants and levonorgestrel intrauterine system (LNG-IUS) in reproductive-aged women. In April 2024, we searched Pubmed, Embase and Cochrane trials using the search terms: “etonogestrel”, “levonorgestrel” and “randomized controlled trials”. We identified 2862 results comparing the LNG...
Alongside being contraceptives, progestins have been investigated as potential anti-inflammatory and analgesic therapies for use in painful gynaecological conditions. This review aims to synthesise evidence pertaining to the efficacy of progestins as analgesics for use in endometriosis, fibroids and pre-menstrual syndrome (PMS). We conducted a systematic review of the extant...
To assess the delivery complications in neonates with meconium stained amniotic fluid (MSAF) and small for gestational age (SGA) birthweight. The medical records of all term, singleton deliveries during 2014–2021 were reviewed. Obstetric characteristics and neonatal outcomes were evaluated among the following groups: SGA neonates with MSAF (SGA-MSAF group), SGA neonates without...
Endometrial carcinoma (EC) represents the most prevalent malignancy of the female genital tract in the United States, with lymphovascular space invasion (LVSI) recognized as a critical prognostic factor that significantly influences disease outcomes. This review aims to elucidate the evolving understanding of LVSI in early-stage EC, highlighting its implications for...
Pelvimetry is often recommended in primiparous patients before offering vaginal breech delivery. Later studies show a reduction in perinatal mortality in women undergoing pelvimetry while earlier studies show the opposite. Magnetic resonance imaging (MRI), considered a new technology in 1990, has become the more expensive method for pelvimetry with lower-radiation, believed to...
To compare the anatomical changes of the uterine niche in women before and after hysteroscopic niche resection (HNR) and to investigate the correlation between these changes and the improvement in postoperative spotting symptoms by thin-slice MRI. This prospective observational study enrolled women with symptomatic uterine niches between June 2019 and February 2024. All...
Endometriosis is one of the common endometrial pathologies that occurs in reproductive-age women and could lead to infertility. This study set out to observe which clinical management of endometriosis with endometrioma is prominent in improving IVF outcomes. This was a retrospective cross-sectional controlled study at Bunda General Hospital and Morula IVF Jakarta Clinic...