Background: This study evaluates the impact of cranial reconstruction therapy combined with lumbar drainage on inflammatory cytokine levels (IL-6, IL-1b, IL-8), serum albumin, and cerebrospinal fluid (CSF) biochemical markers in patients with lateral skull base temporal bone fractures and cerebrospinal fluid leakage. It also assesses the role of nutritional and psychological care...
Background: Acute cerebral infarction (ACI) is a frequent type of stroke disease in clinical practice. Cognitive dysfunction is a common complication of ACI, which severely influences the quality of life of patients. Objective: To evaluate the effects of butylphthalide sequential therapy on inflammatory markers (PTX-3, S100B, IL-6) and cognitive outcomes in patients with acute...
Background: The study aimed to demonstrate the impact of traditional Chinese medicine (TCM) matrine combined with omeprazole enteric-coated tablets on gastric mucosal histopathology, gastric function, inflammatory cytokines, and Helicobacter pylori (H. pylori) eradication in patients with chronic atrophic gastritis (CAG). Methods: A retrospective collection of case data from 110...
Background: To evaluate the therapeutic effects of entecavir combined with reduced glutathione on serum type III procollagen (PCIII), plasma procollagen V (IVC), Tumour Necrosis Factor-a (TNF-a), interleukin-6 (IL-6), and nutritional status in patients with hepatitis B complicated by alcoholic liver cirrhosis. Methods: This study included 92 patients with alcoholic liver...
Background: To explore the prognostic value of cancer antigen 15-3 (CA15-3), Carbohydrate antigen 125 (CA125), and carcino-embryonic antigen (CEA) in breast cancer patients undergoing chemotherapy. Methods: The data of 100 patients with breast cancer who received chemotherapy in a hospital from May 2022 to May 2024 were selected. Patients were divided into control and test groups...
Background: This study aimed to explore the impact of T helper 17 (Th17)/regulatory T (Treg) cells imbalance and inflammatory factors (IL-1b, IL-18, and TNF-a) on sagittal balance in patients with thoracolumbar kyphosis due to ankylosing spondylitis (AS) following vertebral column decancellation (VCD), to clarify the predictive efficacy of the Th17/Treg ratio and IL-1b, IL-18...
Background: This study aimed to evaluate the effectiveness and safety of the hybrid artificial liver support system (HALSS) in patients with chronic liver failure (CLF). It also sought to analyze the inflammatory response and patient prognosis. Methods: A total of 126 CLF patients were divided into three treatment groups: plasma exchange (PEG), double plasma molecular adsorption...
Background: The study aimed to assess antioxidative status using standard biochemical analyses in multiple sclerosis patients during relapse and remission. Also, to evaluate the effects of gender, drug-modified treatment and clinical characteristics of multiple sclerosis on analyzed antioxidants. Methods: The study consisted of 178 relapse-remitting multiple sclerosis patients...
Background: Coronary heart disease (CHD) is a leading cause of morbidity among elderly populations, with inflammation and cardiac dysfunction indicated by elevated MCP-1 and NT-proBNP levels. This study evaluated the effects of integrating Traditional Chinese Medicine (Baoyuan and Taohong Siwu decoctions) with standard Western therapy on serum MCP-1 and NT-proBNP in elderly CHD...
Background: This study aimed to explore the clinical efficacy of probiotics plus quadruple therapy on Serum levels of tumour necrosis factor-a (TNF-a), interleukin-6 (IL-6), C-reactive protein (CRP), gastrin (GAS) and motilin (MTL) in treating Helicobacter pylori (Hp)-positive gastric ulcer (GU). Methods: One hundred and twenty-four patients with Hp-positive GU treated in our...
Background: Alzheimer's disease (AD) is a degenerative disease of the central nervous system characterized by neuroinflammation and amyloid deposition. Folic acid (FA), a B vitamin, may improve the course of AD by modulating inflammation and neuroprotection. This study aimed to investigate the effects of FA supplementation on serum inflammatory cytokines (IL-1b, IL-6, TNF-a...
Background: This work investigated the changes in myocardial enzyme profile (MEP) and short-term prognosis (STP) in patients with myocardial damage (MD) after transcatheter aortic valve replacement (TAVR). Methods: 100 patients receiving TAVR surgery were selected and rolled into an observation group (Obs group, 50 cases) and a control group (Ctrl group, 50 cases) according to...
Background: The aim of this study was to carried out an exploration of the predictive value of serum high-sensitivity C-reactive protein (hs-CRP) plus high levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) for the onset of ischemic stroke (IS). This study extends the understanding of their interplay by highlighting their mechanistic contributions to vascular...
Background: To observe the relationship between the expression of serum interleukin-6 (IL-6) and neutrophil/lymphocyte ratio (NLR) and the prognosis of patients with acute liver failure (ALF) treated with artificial liver. Methods: 80 patients with ALF from January 2021 to October 2023 were included. All of them received artificial liver system treatment. All of the included...
Background: Orthostatic hypotension (OH) in maintenance hemodialysis (MHD) patients is a frequent chronic complication. OH may lead to inadequate dialysis, cardiovascular complications, and death. This study explored the relationship between OH and various factors, including serum levels of parathyroid hormone (PTH), potassium (K+), calcium (Ca2+), blood phosphate (PO4), albumin...
Background: This study aims to evaluate the effects of high-quality nursing combined with immune-type enteral nutrition (IEN) support on postoperative recovery, nutritional status, immune function, inflammatory response, and complication rates in patients undergoing radical colon cancer resection. Methods: A total of 106 patients with colon cancer who underwent radical resection...
Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a specific biomarker associated with an increased risk of coronary artery disease (CAD) development. This study aims to determine the relationship between Lp-PLA2 activity and the risk of development and severity of CAD in patients with type 2 Diabetes mellitus (T2DM). Methods: The cross-sectional study included 148...
Background: Given the critical importance of inflammation, immune and endothelial function in acute respiratory failure (ARF), it is essential to evaluate therapeutic strategies that target these pathways to confirm their application value. This study aimed to investigate the impact of chain management (defined as a systematic protocol integrating dynamic risk assessment...
Background: Serum ferritin (SF) monitors secondary iron overload in beta-thalassemia (b-thalassemia). Transferrin (TRF) has been shown to reverse iron accumulation in experimental models, but its role in transfusion-dependent beta-thalassemia (TDT) patients remains unclear. This study aims to explore the relationship between TRF and SF in TDT patients and to reveal the unique...
Background: This study investigates the effects of Ginkgo Diterpene Lactone Meglumine (GM) combined with Clopidogrel (CLO) on hemodynamics, neurocytokines, and inflammatory responses in patients with cerebral infarction (CI) complicated by coronary heart disease (CHD). Methods: A total of 152 patients diagnosed with CI complicated by CHD, admitted to our hospital between January...
Background: This study aimed to develop a risk score model for predicting acute kidney injury (AKI) in children with sepsis, using red blood cell distribution width (RDW), Acute Physiology and Chronic Health Evaluation II (APACHE II) score, and additional biomarkers (PCT, IL-6, CRP, and cystatin C) based on logistic regression (LR) analysis. Methods: Children treated in the ICU...
Background: Oxidative stress (OS) plays a crucial role in colorectal cancer (CRC) progression. Lactobacillus has been proposed as a potential modulator of OS. This randomised controlled trial aimed to evaluate the effects of Lactobacillus supplementation on OS markers and its related signalling pathways in CRC patients after surgery. Methods: A total of 76 CRC patients were...
Background: This study aimed to evaluate and compare the diagnostic value of C-reactive protein (CRP), procalcitonin (PCT), neutrophil count (NC), and neutrophil-to-lymphocyte ratio (NLR) in peripheral blood for detecting bacterial infections in patients with non-small cell lung cancer (NSCLC) following chemotherapy. Methods: A total of 122 NSCLC patients treated at our hospital...
Background: This study aimed to identify novel methyla-tion-based prognostic biomarkers for endometrial cancer (EC) to facilitate early diagnosis and treatment. To explore methylation-related prognostic markers in endometrial tis-sue by analyzing TCGA data and to establish a methylation-based risk model for EC patients. Methods: We systematically analyzed methylation-related gene...
Background: Cerebral venous sinus thrombosis (CVST) with concurrent brain parenchymal injury is a severe and complex condition that requires effective treatment strategies and long-term follow-ups. This study aimed to evaluate the prognostic value of serum caspase-cleaved cytokeratin-18 (CCCK-18), neuron-specific enolase (N SE), S-100P, nerve growth factor (N GF), and CRP D-Dimer...