Abstract Objectives: The mechanisms of acute liver failure resulting from epilepsy are poorly defined and appear to be multifactorial, including hypoxia and steatosis. The role of inflammation on liver damage after seizures is unclear. This study aimed to investigate the relationship between proinflammatory cytokines and liver damage after pentylenetetrazole-induced acute and...
Urinary system congenital anomalies are more common than other systems. The double collecting system is caused by the emergence of two separate ureter buds from a single Wolff duct or incomplete fusion of the ureter bud with the upper and lower pole parts of the kidney. The opening of the ureter orifice to the bladder neck or to a point other than trigon is called an ectopic...
Objective: Genetic factors have been the subject of many studies in cancer etiology. One of the most striking of these is the relationship between blood groups and cancer. Therefore, in our study, we examined the relationship between blood groups of stomach, colorectal, breast, thyroid and pancreatic cancers, which are common in general surgery practice, with single-center data...
Anti-tumor necrosis factor agents are effective drugs for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. Although it is indicated for the treatment of Ankylosing Spondylitis, there are recent publications about paradoxical side effects due to these agents, mostly in the form of case reports. In this article, we present the psoriasis case that...
Objective: In this study, we aimed to compare early and late outcomes of patients with abdominal aortic aneurysm (AAA) treated using an endovascular approach and open aneurysm repair technique. Method: A total of 171 patients who were undergoing EVAR and open surgical therapy were retrospectively analyzed under elective conditions due to abdominal aortic aneurysm via Hospital...
Objective: It’s recommended to use equations such as Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) by using creatinine level in estimating glomerular filtration rate (GFR). Here, we aimed to compare serum cystatin-C (Cys-C) and Cys-C based equations with creatinine and creatinine based equations in patients with...
Objective: The aim of this study is to investigate the frequency of neurological and other involvement patterns of the Primary Sjögren’s syndrome (pSS). Method: Between June 2015 and January 2017, sixty SJS patients who were being followed up at Cumhuriyet University Medical Faculty Rheumatology-Internal Medicine Department were evaluated in the study. Their clinical complaints...
Objective: There is strong evidence that a high fat intake causes cholesterol increases in human body. We all know high cholesterol levels causes cardiovascular diseases. This study was aimed to investigate the fat content in cheddar cheese which coagulated with Citrus reticulata Blanco crude flowers extracts (CFE) at four different concentrations (1, 2, 3 and 4%, v/v). Method...
Objective: PD-1 (programmed death-1) is an immune checkpoint receptor that modulates T-cell activity in peripheral tissues via interaction with its ligands, PD-L1 (programmed death-ligand 1) and PD-L2 (programmed death-ligand 2). Tumor cells upregulate PD-L1 or PD-L2 to dampen T lymphocyte attack. The checkpoint inhibition by tumor cells via the PD-1 pathway suppress the...
Objective: The aim of this study is to evaluate the epidemiological, clinical, laboratory, and radiological characteristics of 63 possible and definite COVID-19 patients who were followed up and treated in Sivas Cumhuriyet University Pandemic Clinic in April and May, 2020. Method: In this retrospective study, the diagnosis and treatment of the patients were made according to the...
Objective: Primary hyperparathyroidism (PHPTH) is an endocrine disorder with hypercalcemia due to increased parathormone (PTH) release. This study aims to investigate the relationship between PHPTH and serum zinc and copper levels. Method: 35 patients diagnosed with PHPT and 30 healthy control cases were included in the study. Serum zinc and copper levels were measured in all...
Coronavirus Disease-19 ( COVID-19) is a disease that started at the end of 2019 and continues to affect all the world as a pandemic. There is no definitive cure for COVID-19 yet. The disease is characterized by excessive immune activity, inflammation and coagulopathy. Many agents have been tried for treatment and prevention. Flavonoids are valuable natural food components with...
This disease, which is called COVID-19 disease due to the SARS COV2 virus, which emerged as a result of the mutation of the coronavirus in China in 2019, and caused significant morbidity and mortality all over the world due to the pandemic it created, has become the world's most important health problem. COVID-19 clinic emerges in a wide spectrum from mild viral infection to...
Objective: To investigate changes in corneal endothelial cell density, corneal morphology and central corneal thickness in patients with ocular rosacea. Method: 60 eyes of 30 ocular rosacea patients and 60 eyes of 30 control group with similar demographic characteristics were included in the study. Detailed ophthalmological examination was performed in all individuals...
Objective: Increased urinary excretion of uric acid has been shown to be associated with vesicoureteral reflux (VUR). The aim of this study is evaluate if urinary uric acid/creatinine ratio can be used as a surrogate for renal scarring in VUR. Method: Retrospective chart analysis was made to identify patients who were diagnosed with VUR. Those with secondary VUR, <3 years of age...
Objective: Distal radius fractures are one of the fracture types seen most often in the Emergency Department. Therefore, the incidence of distal radius fractures could be of guidance in determining how fracture incidence is affected by a reduction in a normal community activity. The aim of this study was to compare the epidemiology of distal radius fractures in a 6-month period...
Objective: In this study, our aim is to analyze the etiological causes and treatment methods of patients with secondary spontaneous pneumothorax treated in our hospital. Method: We retrospectively evaluated the data of 152 patients who were treated for Secondary spontaneous pneumothorax between January 2013 - December 2017. All patients diagnosed with SSP were included in the...
Objective: The basic aim in the treatment of second-degree burns is to prevent progressive cell death, and so treatments are directed at the zone of stasis. In this study, We were aimed to investigate the healing effects of using Mesenchymal Stem Cells (MSCs), Ovarian follicular fluid (OFS) and Platelet-rich plasma (PRP) on burn stasis zone in an experimental burn model. Method...
Objective: To determine the A, B, O, AB blood group distribution and Rhesus (Rh) positivity rate of Sivas province, and thus to know the distribution of blood groups in our region and to use it in a practical and scientific manner when necessary. Method: The blood group results of a total of 50,441 individuals over the age of 18 who applied to Sivas Cumhuriyet University Health...
Objective: Tp-e, QT, and Tp-e / QT are parameters showing ventricular repolarization. The increase in these parameters causes an increase in cardiovascular mortality, mostly due to malignant arrhythmias. Our study aimed to compare the long-term changes in electrocardiographic parameters in patients with uncontrolled diabetes despite using metformin, with the addition of SGLT 2...
A poorly managed pain is associated with many negative results. These results disturb patients, their families and societies. Although opioid agents have extraordinary analgesic efficacy, they may cause serious adverse consequences. For medication of pain, there is a medical need to discover possible alternatives to opioids. In animal models of acute pain synthetic cannabinoid...
Objective: We aimed to make a differential diagnosis of brain metastases by using the percentage of the ITSS by the SWI sequence. Method: MR images of 77 patients with intracerebral metastases were evaluated in this study who had breast carcinoma (BC)(n=23), malignant melanoma (MM)(n=4), lung cancer (LC) (n=42), and gastrointestinal adenocancer (GIA)(n=8) as the primary tumor. We...
Objective: A healthy lifestyle can be defined as the adoption and implementation of behaviors that will reduce the risk of a serious illness or premature death, as well as protect and improve health levels. The aim of this study was to determine healthy lifestyle behaviors of students in a medical faculty and to investigate the relationships between healthy lifestyle behaviors...
Objective: The aim of this study was to evaluate the clinical features of tuberculosis (TB) in terms of gender differences over a ten-year period. Method: This retrospective cohort study was performed using Sivas Tuberculosis Dispensary 2010- 2019 TB patient records. TB incidence, mortality, drug sensitivity percentages and some clinical characteristics of patients were...
Objective: Index of cardiac electrophysiological balance (iCEB) is a relatively new electrocardiographic (ECG) parameter that shows the balance between ventricular depolarization and repolarization, thus providing more information than other conventional ECG parameters such as QT and corrected QT (cQT) intervals. This study aimed to evaluate the condition of iCEB with the...