Investigating the expression levels of immune checkpoint genes CD276, CD40, TNFSF14, and TNFSF9 in glioblastoma multiforme patients about copper death and patient prognosis. Transcriptional data of GBM patients were obtained from the TCGA database. LASSO Cox regression analysis was performed to identify four immune checkpoint genes (CD276, CD40, TNFSF14, and TNFSF9) associated...
Colorectal cancer (CRC) remains a significant global health burden, ranked among the most common causes of cancer-related fatalities. While insulin resistance (IR) biomarkers have been associated with CRC prognosis, their role in predicting metastasis remains unclear. Metastasis remains a critical determinant of prognosis and treatment planning in CRC. Identifying precise...
Although the number of clinical trials on lung cancer is rapidly increasing, the clinical benefits have not received sufficient attention. This study aims to assess the clinical benefits and estimate the minimal clinically important differences (MCIDs) for overall survival (OS) and progression-free survival (PFS) to provide quantitative guidance for treatment decisions and study...
CircRNAs have a potential regulatory effect on Renal cell carcinoma (RCC). However, there is still a significant lack of research on their action pathways and mechanisms in the treatment of RCC. The aim of this study is to identify the effects of Circ_001024 on the proliferation, migration, and invasion of RCC cells, and to elucidate the molecular mechanisms by which Circ_001024...
NETO2 is a gene with potential prognostic value in various cancers, but its role in oral squamous cell carcinoma (OSCC) remains unclear. This study investigates NETO2 expression, clinical significance, and its association with the tumor immune microenvironment in OSCC. NETO2 expression in OSCC tissues was analyzed using public databases and correlated with prognosis via Kaplan...
Multiple Myeloma (MM) is a hematological malignancy originating from the bone marrow and affecting the germinal lymphoid B cells, resulting in abnormal plasma cells and end organ damage. Genetic profiling is necessary for risk stratification and optimized management. The genetics of MM patients in the Middle East, particularly in Lebanon, have been scarcely reported. This lack of...
Cervical cancer remains a major threat to women’s health worldwide. Discoidin domain receptor 1 (DDR1) drives immune evasion in a variety of cancers, but its expression pattern, clinical significance, and immunoregulatory mechanisms in cervical cancer have not been clarified. DDR1 expression profiles were resolved based on TCGA and GEPIA2 databases; DDR1-related pathways were...
Single nucleotide variants are important factors involved in lung cancer onset and prognosis. In Cuba, there are scarce studies evaluating the possible association between genetic variants and lung cancer. Here, we described the frequency distribution of genetic variants in DNA repair related genes and assessed their impact on lung cancer susceptibility and survival prognosis in...
Conventional ultrasonography (cUS) and contrast-enhanced ultrasonography (CEUS) are used to evaluate breast cancer tumors and axillary lymph nodes (ALN), by which the treatment strategy for breast cancer is determined. A breast tumor size discrepancy on CEUS compared with cUS is often observed, for which the reasons are unclear. We hypothesized that this discrepancy reflects the...
We conducted an assessment to investigate the impact of prostate volume on the recurrence of patients with non-muscle invasive bladder cancer (NMIBC). Subsequently, we developed and validated nomograms to accurately evaluate recurrence in NMIBC patients. Additionally, we examined the potential improvement in predictive capability achieved by introducing prostate volume as a...
Thromboembolism (TE) is a serious complication in lymphoma, driving excess morbidity and mortality. Existing prediction tools perform suboptimally in lymphoma-specific settings. We retrospectively analysed 790 newly diagnosed lymphoma patients (January 2019–December 2021). Patients were randomly split 7:3 into development and internal-validation cohorts. Forty-eight candidate...
This study assesses the prognostic value of the controlling nutritional status score (CONUT) in colorectal cancer patients. A systematic search was performed in PubMed, Embase, Web of Science, and Cochrane databases until December 2024. The primary outcomes were overall survival (OS), disease-free survival (DFS), and relapse-free survival (RFS). Hazard ratios (HR) with 95...
The interplay between nutritional and inflammatory status and sedentary behavior is intricate, and both are associated with the prognosis of cancer survivors. However, the combined effect of these factors on the mortality rate of cancer survivors remains unclear. We selected cancer survivors from the National Health and Nutrition Examination Survey (2007–2018). The Naples...
Increasing evidence implicates the NF-κB/p65 signaling pathway in the progression of prostate cancer (PC) and the development of resistance to androgen deprivation therapy. This study aimed to investigate the potential role of UHRF1, a key epigenetic regulator, in modulating NF-κB activity, and to evaluate its association with clinicopathological features and clinical outcomes in...
Osteosarcoma (OS) relies on the Warburg effect for aggressive growth and chemotherapy resistance, but strategies to disrupt this metabolic adaptation remain limited. This study aimed to identify novel noncoding RNA regulatory mechanisms governing the Warburg effect in OS and explore potential therapeutic targets. Integrated bioinformatics analysis (GEO dataset GSE126209) was...
Gastric cancer (GC) exhibits diverse molecular characteristics, among which microsatellite instability (MSI) plays a pivotal role in determining treatment responses, particularly to immune checkpoint inhibitors (ICIs). Mismatch repair (MMR) protein immunohistochemical (IHC) staining is a primary screening method for MSI; however, heterogeneity in staining patterns can complicate...
Cancer remains a leading global health burden, with projections estimating 35 million new cases by 2050. The Speckled Protein 100 (SP100) family, comprising SP100, SP110, SP140, and SP140L, has emerged as a critical player in cancer biology due to their roles in transcriptional regulation, chromatin modification, and immune signaling. While SP100 acts as a tumor suppressor in...
Few biomarkers can predict the effectiveness of transcatheter arterial chemoembolization (TACE) in combination with systemic therapies for patients with advanced hepatocellular carcinoma (HCC). This study aimed to evaluate the prognostic significance of changes in alpha-fetoprotein (AFP) and prothrombin induced by vitamin K absence-II (PIVKA-II), as well as their clinical utility...
Bladder cancer is a high-incidence malignant tumor in the world. Currently available potential biomarkers lack sufficient diagnostic accuracy, underscoring the need for novel biomarkers. Lipid metabolites have emerged as promising candidates for diagnosing malignant tumors in recent years. Few studies explored the potential value of lipids in bladder cancer. Our study...
The HOXB13 gene has been associated with hereditary prostate cancer (PCa), with rare germline variants linked to early-onset and aggressive forms of the disease. While the G84E variant has been well-characterized in Caucasian populations, the clinical relevance of the X285K variant—primarily found in individuals of African ancestry—remains unclear. This study aimed to determine...
Multiple myeloma (MM) is a neoplasm of antibody-producing plasma cells and is the second most prevalent hematological malignancy worldwide. Development of drug resistance and disease relapse significantly impede the success of MM treatment, highlighting the critical need to discover novel therapeutic targets. In a custom CRISPR/Cas9 screen targeting 197 DNA damage response...
The evaluation of axillary lymph nodes (ALNs) using ultrasound (US) plays a crucial role in the diagnosis and management of breast cancer. This study aims to assess the diagnostic performance of both quantitative and qualitative features of suspicious ALNs using superb microvascular imaging (SMI). To the best of our knowledge, this is the first prospective study in the literature...
The American Heart Association released an updated algorithm used to assess cardiovascular health (CVH)-the Life’s Essential 8 (LE8) score. Our objective was to quantify the association between CVH levels estimated by the LE8 score and all-cause and cardiovascular mortality in adults with and without cancer. In this retrospective cohort study, 29,352 adults were included from the...
Neoadjuvant chemotherapy (NAC) combined with human epidermal growth factor receptor 2 (HER2)-targeted agents is the mainstay of treatment of HER2-positive (HER2 +) breast cancer (BC). We investigated intrinsic subtypes and clinicopathological features as predictors of outcomes of NAC in HER2 + early-stage BC patients. Of 186 consecutive patients with early-stage HER2 + BC, as...
Despite significantPlease check if article title presented correctly. advances made by genome-wide association studies (GWAS) in the genetic exploration of tumors such as prostate cancer (PCa), the precise pathogenic genes and underlying biological mechanisms of PCa remain unclear. To address this complex issue, we used a cross-tissue transcriptome-wide association study (TWAS...