Hypertension and non-alcoholic fatty liver disease (NAFLD) frequently coexist and share metabolic pathways that elevate cardiovascular and all-cause mortality risk. Although physical activity (PA) is known to reduce cardiovascular risk, its impact among individuals with both hypertension and NAFLD remains unclear. This nationwide cohort study examined the independent and joint...
As Japan faces rapid population aging, understanding modifiable risk factors for dementia is critical. This review explores the impact of hypertension and blood pressure (BP) management on dementia onset. Midlife hypertension emerges as a key risk factor, especially for vascular dementia, while late-life BP effects are variable. Observational studies suggest a critical window for...
The Japanese Society of Hypertension Guidelines (JSH 2019) introduce stricter blood pressure (BP) targets, but BP status (hypertension prevalence and treatment) and control rates under these criteria, particularly by home BP monitoring, remain limited. This study investigated BP status, guideline-based BP control rates, and associated factors in a community-dwelling population...
Endovascular aortic repair (EVAR) treatment was associated with increase in arterial stiffness following the procedure abdominal aortic aneurysm (AAA). This study aims to investigate the impact of different stent-graft materials on arterial stiffness measurements and the outcomes of AAA patients undergoing EVAR. Patients with AAA undergoing EVAR were eligible for this study...
The combined effects of aging, sex, and body mass index (BMI) on blood pressure trajectories remain incompletely characterized in large-scale populations. The aim was to describe age-related blood pressure trajectories according to sex and BMI, as understanding these patterns is essential to improve risk stratification and develop preventive strategies for hypertension and...
Identifying and prioritizing modifiable risk factors is crucial for the primary prevention of hypertension. However, large-scale data on the population attributable fraction (PAF) for a comprehensive range of modifiable risk factors for incident hypertension in the Japanese population have been scarce. This study analyzed 1,069,948 participants (median age 56, 43.7% men) without...
Intermittent hypoxia (IH), the key physiological stressor in obstructive sleep apnea, is commonly quantified by respiratory event frequency. However, clinical heterogeneity in hypertension among patients with comparable apnea-hypopnea index (AHI) suggests that episode timing, including the duration and frequency of desaturation-reoxygenation cycles, may exert distinct biological...
Prevention of hypertension (HT), a risk factor for cardiovascular diseases, and blood pressure (BP) control are important. For the prevention and management of high BP, increased physical activity (PA) is recommended as a lifestyle intervention. Although various PA assessment methods exist, their associations with clinical BP have been inconsistent. This study aimed to compare...
Constant light (LL) disrupts biological rhythms, although more data are available on circadian than on ultradian rhythms. LL has been linked to elevated blood pressure (BP), although most evidence comes from tail-cuff plethysmography in males. However, in nocturnal animals, LL should suppress activity, increase sleep, and lower BP. Therefore, the aim of this study is to provide a...
The sympathetic nervous system plays a pivotal role in the pathophysiology of hypertension. Although the contribution of the sympathetic nervous system to an elevation of blood pressure is well established, the determinants of persistent sympathetic overactivity remain incompletely understood. This review summarizes the findings of recent basic research that have expanded the...
Excessive dietary salt intake remains a major public health concern in Japan and worldwide, contributing to noncommunicable diseases, including hypertension and cardiovascular disease. Although national health promotion strategies in Japan have emphasized behavioral change through nutrition education and awareness campaigns to achieve population-level salt-reduction targets...
Mobile health (mHealth)-based disease management programs enable continuous monitoring of blood pressure (BP) and related health behaviors. Feature engineering may help to extract informative predictors from longitudinal data, potentially improving BP change prediction. This study aimed to evaluate whether feature-engineered predictors can improve the prediction of systolic BP...
Hypertension, encompassing white-coat hypertension (WCH), masked hypertension (MH), and sustained hypertension (SH), is an established risk factor for cardiovascular diseases (CVDs), including atherosclerosis. However, among the general population, findings on which target organ is affected by the different phenotypes of hypertension remain unclear. In this community-based...