American Journal of Neurodegenerative Disease

List of Papers (Total 125)

Exceptionally giant neglected sacral chordoma in a post-poliotic residual paralysis patient - a rare case scenario.

Chordoma is a rare malignant tumour with an incidence of 0.1 case per 1 lakh population per year. The sacrococcygeal region is the most common site to be involved. Herein, we are reporting a case of sacral chordoma, who is a 32-year-old male patient, ...

Evaluation of willingness to obtain of Covid 19 vaccine in patients with multiple sclerosis.

Introduction: Assessing vaccine willingness and understanding sources of vaccine hesitancy in individuals with multiple sclerosis (MS) helps healthcare providers approach patients more effectively while respecting their autonomy to encourage coronavirus ...

Neurological manifestation in COVID-19 disease with neuroimaging studies.

Objective: Magnetic resonance imaging (MRI) of the brain or spine examines the findings as well as the time interval between the onset of symptoms and other adverse effects in coronavirus disease that first appeared in 2019 (COVID-19) patients. The goal ...

Parkinson's genetics research on underrepresented AfrAbia populations: current state and future prospects.

Parkinson’s disease (PD), the most common motoric neurodegenerative illness, has been extensively researched to better understand its complex pathophysiology. Nearly 80% of genome-wide association studies have been conducted on persons of European ...

A rare case of hypomelanosis of Ito with enlargement of Virchow-Rabin spaces in a 10-year-old child with symptoms of seizures.

Hypomelanosis of Ito (HI) syndrome is a complex neuro-dermatological disorder that affects many organs in the body, including the skin, brain, eyes, and skeleton. This disease has been reported to present with seizures in a few rare cases. Seizures are ...

Prevalence of lumbosacral transitional vertebra in patients with chronic low back pain: a descriptive cross-sectional study.

Background: Numerous causes of low back pain have been identified like spondylosis, spondylolysis, spondylolisthesis, facet lesions, discal abnormalities, vertebral instability, degenerative osteoarthritis, etc., These causes of low back pain are seen ...

Botox injection in treatment of sialorrhea in children with cerebral palsy.

Background: The occurrence of sialorrhea (drooling) in children with cerebral palsy is one of the important complications of this disease, which is associated with the impaired quality of life of patients and also the dissatisfaction of their parents. ...

Nucleus accumbens changes in amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis (ALS), a representative example of motor neuron disease, is a progressive and fatal neurodegenerative disorder. The nucleus accumbens (NA) is the ventral striatum’s main part and is considered as a modulator of the ...

Evaluation of spinopelvic parameters in patients with lumbosacral transitional vertebra: a cross sectional and comparative study.

Introduction: Lumbosacral transitional vertebra (LSTV) is the most common congenital anomaly of the lumbosacral junction and is a frequent cause of back pain in young patients with a prevalence of 4.6% to 36% in different regions. Objective: The objective ...

Leveraging genetic diversity to understand monogenic Parkinson's disease's landscape in AfrAbia.

Parkinson’s disease may be caused by a single highly deleterious and penetrant pathogenic variant in 5-10% of cases (monogenic). Research into these mutational disorders yields important pathophysiological insights. This article examines the phenotype, ...

Single-cell RNA sequencing analysis and Alzheimer's disease: a bibliometric analysis.

Alzheimer’s disease (AD) is a devastative disease, the 1[st] most frequent neurodegenerative disease worldwide. Its prevalence is increasing and early detection methods as well as potential genomic based therapeutics are urgently needed. Objectives: ...

Short segment posterior fixation of unstable thoracolumbar vertebral fractures with fractured vertebra augmentation with intermediate pedicle screw - a clinicoradiological analysis.

Introduction: Unstable thoracolumbar burst fractures are routinely encountered in orthopedic practice. Recently, short-segment fixation with pedicle screw augmentation of the fractured vertebra for unstable thoracolumbar burst fractures has gained popularity. ...

Cognitive impairment and changes of red blood cell components and serum levels of IL-6, IL-18, and L-tryptophan in methamphetamine abusers.

The deficit in cognitive function is more concerning in methamphetamine (MA) users. The cognitive deficit was suspected to be the consequence of neuroinflammation-induced neurological dysregulation. In addition, activating the key enzyme in the tryptophan ...

SKINTED: an uncommon cutaneous complication of total knee replacement.

Surgery of the knee, injury to the infrapatellar branch of the saphenous nerve, traumatic eczematous dermatitis (SKINTED) involving the skin lateral to the surgical incision/scar area is a site- and procedure-specific diagnosis associated with total knee ...

Predictive value of number and volume of demyelinating plaques in treatment response in patients with multiple sclerosis treated with INF-B.

Background: Multiple Sclerosis (MS) is an autoimmune, inflammatory disease of the central nervous system. Magnetic resonance imaging (MRI) findings are associated with disease clinical activity and response to treatment. This study aimed to evaluate the ...

Effect of Modafinil on functional connectivity in healthy young people using resting-state fMRI data.

Background: Examining the differences in the Functional Connectivity (FC) network while using Functional Magnetic Resonance Imaging (fMRI) between two groups can expand the understanding of neural processes and help diagnose and prevent neurological progression ...

Integrated case-based clinical approach in understanding pathways, complexities, pitfalls and challenges in neurodegenerative disorders.

Introduction: This paper presents 5 cases of neurodegenerative disorders from our tertiary care rural hospital in south India. The purpose of this paper is to generate an emerging common theme by thematic analysis of clinical data from each of these patients. ...

Nucleus accumbens atrophy in Parkinson's disease (Mavridis' atrophy): 10 years later.

Parkinson’s disease (PD) is a common neurodegenerative disorder associated with gray matter atrophy. The human nucleus accumbens (NA) is a major part of the ventral striatum and modulator of the reward network of the brain. It plays an important ...

Status epilepticus due to COVID-19; a cases series and literature review.

Complications are increasingly recognized with SARS-CoV-2, the causative pathogen for COVID-19. Various mechanisms have been proposed to justify the cause of seizures in Covid-19 patients. To our knowledge, 13 cases of status epilepticus (SE) associated ...

Prevalence, clinical, imaging, electroencephalography and laboratory characteristics of seizures in COVID-19.

Background: COVID-19 is the cause of the recent pandemic. Viral infections could increase the risks of neurological impairments, including seizures. Here, we aimed to evaluate the prevalence, clinical, imaging, electroencephalography and laboratory characteristics ...

The relationship between menstrual disorders and education in women with intractable epilepsy.

Objective: The study aimed to investigate the relationship between menstrual disorders and education in women with intractable epilepsy. Method: This was a descriptive-analytical study. Statistical population consisted of all female patients with intractable ...

Parsonage-Turner syndrome: a firsthand experience of an uncommon malady.

Parsonage Turner Syndrome (syn. idiopathic brachial plexopathy, neurologic amyotrophy) is a rare syndrome of poorly understood etiology with a reported incidence of 1.64 in 1 lakh persons per year. It affects men more often than women with a highest incidence ...