LetterThe imaging of total kidney volume in ADPKDGioacchino Li Cavoli1 http://orcid.org/0000-0002-8252-6588Francesca Finazzo2 Rosalia Mongiovi1 Luisa Bono1 Angelo Ferrantelli1 Vitalba Azzolina1 Calogera Tortorici1 Barbara Oliva1 Antonio Amato1 Carlo Giammarresi1 Carmela Zagarrigo1 Camillo Carollo1 Franca Servillo1 Onofrio Schillaci1 Angelo Tralongo1 1Azienda Ospedaliera di...
We report an unusual case of a 24-year-old girl with a history of recurrent hypokalemic paralysis episodes and skin lesions on the lower limbs and buttocks, both of which had an acute evolution. In subsequent investigations, the patient also had nephrocalcinosis, nephrolithiasis, hyperchloremic metabolic acidosis and persistent alkaline urinary pH. The findings were consistent...
Introduction:Infectious complications are common in systemic lupus erythematosus. Although uncommon, central nervous system infections do occur and have significant lethality, with several etiological agents.Methods:We report on the case of a 29-year-old woman recently diagnosed with systemic lupus erythematosus with hematological, cutaneous, serous and renal manifestations...
Encapsulating Peritoneal Sclerosis (EPS) is a severe and rare condition frequently associated with peritoneal dialysis, characterized by bowel obstruction, with lethal consequences in 20% of the patients. The disease presents as a mass of fibrous tissue encapsulating visceral organs that may potentially compromise digestive tract function. This report describes the case of a...
Imatinib, which inhibits tyrosine kinase activity of Bcr-Abl protein, is a standard form of treatment for chronic myeloid leukemia (CML). Through its immunomodulatory effect it affects T cell function in a number of ways. It inhibits antigen-induced T cell activation and proliferation. Antigen-specific T-cells and macrophages are vital for protection against Mycobacterium...
Given the high transmissibility of SARS-CoV-2, COVID-19 pandemic has a huge impact on our health system. Even in developed countries, strategic resources soon become insufficient. Although people over 60 and with comorbidities are at greater risk of developing severe forms, younger people may also require precious and scarce care. Hence, the World Health Organization recommend...
Technological innovations often occur and make an impact on many industries. In academia, Visual Abstracts have been a trend and represent a creative and dynamic way to disseminate scientific knowledge. Although still rare in Brazil, more than 15 journals already use Visual Abstracts worldwide. This brief paper intends to present the concept and discuss the potential...
The pregnancy rate of women on dialysis is still very low when compared to that of the remaining population. However, recent years have seen an increase in the success rates of these pregnancies. Among the main precautions that must be taken with pregnant women on dialysis are the maintenance of low levels of pre-dialysis urea, the adequacy of the tension profile, the control of...
Recent epidemiological studies have shown that dietary patterns may have a more persistent impact on the risk of stone formation than single nutrients of the diet. Dietary Approaches to Stop Hypertension (DASH), a low-sodium and fruits/vegetables-rich diet, has been associated with a lower risk of nephrolithiasis, due to altered urinary biochemistry. This observational study...
Introduction:Acute kidney injury (AKI) is a common disorder that causes high healthcare costs. There are limited epidemiological studies of this disorder in low- and middle-income countries. The aim of this study was to describe trends in the age-standardized incidence and mortality rates of AKI in Peru.Methods:We conducted an ecological study based on a secondary data sources of...
Introduction:Metabolic acidosis is associated with the high mortality seen in hemodialysis patients. The panorama of metabolic acidosis in hemodialysis in Brazil is unclear since 1996 when the analysis of bicarbonate levels was no longer a compulsory exam. We aimed to establish the prevalence of metabolic acidosis in a hemodialysis population and analyze the factors associated...
Background:Persistent hyperparathyroidism post-transplant is associated with increases in the incidence of cardiovascular events, fractures, and deaths. The aim of this study was to compare both therapeutic options available: parathyroidectomy (PTX) and the calcimimetic agent cinacalcet.Methods:A single center retrospective study including adult renal transplant recipients who...
Background: Patients with chronic kidney disease (CKD) present an imbalance of the gut microbiota composition, leading to increased production of uremic toxins like p-cresyl sulfate (PCS), product from bacterial fermentation of the amino acids tyrosine (Tyr) and phenylalanine (Phe) from the diet. Thus, diet may be a determinant in the uremic toxins levels produced by the gut...
Introduction: Vascular calcification is a common complication of chronic kidney disease. Osteoblast differentiation factor (Cbfa1) is present in histologic sections of arteries from patients with end-stage renal disease. Vascular smooth muscle cells (VSMC) can dedifferentiate to osteoblast-like cells, possibly by up-regulation of Cbfa1. There is evidence that the production of...
Introduction:Acute kidney injury (AKI) is a recurrent complication in the intensive care unit (ICU) and is associated with negative outcomes.Objective:To investigate factors associated with mortality in critically ill AKI patients in a South Brazilian ICU.Methods:The study was observational retrospective involving AKI patients admitted to the ICU between January 2011 and December...
Introduction:Glomerular hyperfiltration may lead to proteinuria and chronic kidney disease in unilateral multicystic dysplastic kidney (MCDK). We aimed to investigate the urine neutrophil-gelatinase-associated lipocalin (NGAL), netrin-1, hepcidin, and C-C motif chemokine ligand-2 (MCP-1/CCL-2) levels in patients with MCDK.Methods:Thirty-two patients and 25 controls were included...
Introduction:Gut microbiota imbalance is linked to high uremic toxins production such as indole-3-acetic acid (IAA) in chronic kidney disease patients. This toxin can activate the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor involved with inflammation. Strategies to restore gut microbiota balance can be associated with reduced production of IAA and its...
EditorialsMetabolic and dietary features in kidney stone formers: nutritional approachAdamasco Cupisti1 http://orcid.org/0000-0002-8995-936XClaudia D’Alessandro1 1University of Pisa, Department of Clinical and Experimental Medicine, Pisa, Italy Kidney stone disease is not only a pathology of the urinary tract, but it is also closely associated to metabolic abnormalities and...
EditorialsRegional differences in Acute Kidney Injury incidence and mortality in developing countries: recent trendsEtienne Macedo1 http://orcid.org/0000-0002-3669-6519Ravindra L. Mehta1 http://orcid.org/0000-0002-0908-29681University of California, Division of Nephrology and Hypertension, Department of Medicine, San Diego, CA, USA.Acute Kidney Injury (AKI) is a global public...
EditorialsMetabolic acidosis in patients with kidney diseaseSilvia J Leon1 2 http://orcid.org/0000-0003-0006-9596Navdeep Tangri1 2 3 1Seven Oaks General Hospital, Chronic Disease Innovation Centre, Winnipeg, Manitoba, Canada.2University of Manitoba, Max Rady College of Medicine, Department of Community Health Sciences, Winnipeg, Manitoba, Canada. 3University of Manitoba...
EditorialsThe conundrum of parathyroidectomy vs cinacalcet for treatment of post-transplant hyperparathyroidismRima Patel1 Rowena Delos Santos1 http://orcid.org/0000-0002-8844-69251Washington University School of Medicine, Department of Medicine, Division of Nephrology, United States.Persistent hyperparathyroidism in renal transplant patients has been associated with increased...
Introduction:The antiphospholipid syndrome is a systemic autoimmune disease defined by recurrent vascular and/or obstetrical morbidity that occurs in patients with persistent antiphospholipid antibodies.Case presentation:A patient on hemodialysis with a primary antiphospholipid syndrome presented with recurrent vascular access thrombosis, obstetrical complications, and positive...
Idiopathic membranous nephropathy (IMN) is a frequent cause of nephrotic syndrome in adults. In terms of etiology, the condition may be categorized as primary/idiopathic or secondary. Literature on the pathophysiology of IMN has indicated the presence of autoantibodies (PLA2R and THSD7A) directed against podocyte antigens. The detection of antibodies against a domain favors IMN...
This study reports a case of a 13-year-old male with a 3-year history of severe and intermittent hypokalemia episodes of unknown origin, requiring admission to the intensive care unit (ICU) for long QT syndrome (LQTS), finally diagnosed of redistributive hypokalemia secondary to the abuse of β-adrenergic agonists in the context of a probable factitious disorder.Keywords...
One of the most common causes of rapidly progressive glomerulonephritis (RPGN) is pauci-immune crescentic glomerulonephritis (CrGN). In the majority of cases, this condition has a positive serologic marker, the anti-neutrophil cytoplasmic antibodies (ANCAs), but in approximately 10% there are no circulating ANCAs, and this subgroup has been known as the ANCA-negative pauci-immune...