Clinical Research in Cardiology

http://link.springer.com/journal/392

List of Papers (Total 209)

Efficacy of an implantable cardioverter-defibrillator in patients with diabetes and heart failure and reduced ejection fraction

BackgroundThe effect of implantable cardioverter-defibrillator (ICD) therapy in patients with heart failure with reduced ejection fraction (HFrEF) and diabetes is not fully elucidated.MethodsWe examined the effect of ICD therapy on sudden cardiac death, cardiovascular death and all-cause mortality, according to diabetes status at baseline in the Sudden Cardiac Death in Heart...

Incomplete echocardiographic recovery at 6 months predicts long-term sequelae after intermediate-risk pulmonary embolism. A post-hoc analysis of the Pulmonary Embolism Thrombolysis (PEITHO) trial

IntroductionSymptoms and functional limitation are frequently reported by survivors of acute pulmonary embolism (PE). However, current guidelines provide no specific recommendations on which patients should be followed after acute PE, when follow-up should be performed, and which tests it should include. Definition and classification of late PE sequelae are evolving, and their...

Plasma interleukin 6 levels are associated with cardiac function after ST-elevation myocardial infarction

Background and aimsMyocardial infarction triggers an inflammatory response involved in cardiac repair. We studied the association of the interleukin 6 (IL-6) cascade with infarct size and cardiac function after ST-elevation myocardial infarction (STEMI).MethodsIn 369 STEMI patients IL-6, soluble IL-6 receptor (sIL-6R), and soluble glycoprotein (sgp) 130 were measured at baseline...

DGK Herztage 2018 / Annual Meeting vom 11. - 13. Oktober 2018 in Berlin

Deutsche Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e.V. – DGK Herztage 2018 / Annual Meeting. vom 11. - 13. Oktober 2018 im Maritim Hotel Berlin Tagungspräsidenten - Presidents of the congress Tagungspräsident Kardiologie Aktuell Prof. Dr. Johann Bauersachs, Hannover Tagungspräsident Deutsche Rhythmus Tage Prof. Dr. Christian Butter, Berlin Tagungsleiter GIKlive...

Physical inactivity and smoking after myocardial infarction as predictors for readmission and survival: results from the SWEDEHEART-registry

BackgroundPhysical activity (PA) and smoking cessation are included in the secondary prevention guidelines after myocardial infarction (MI), but they are still underutilised. This study aims to explore how PA level and smoking status (6–10 weeks post-MI) were associated with 1-year readmission and mortality during full follow-up time, and with the cumulative 5-year mortality...

Bromocriptine treatment in patients with peripartum cardiomyopathy and right ventricular dysfunction

BackgroundRight ventricular (RV) dysfunction predicts adverse outcome in peripartum cardiomyopathy (PPCM). We recently demonstrated beneficial effects associated with the prolactin release inhibitor bromocriptine at different doses when added to standard heart failure therapy in PPCM. Here, we evaluated for the first time the therapeutic potential of bromocriptine particularly in...

The impact of heart failure and chronic obstructive pulmonary disease on mortality in patients presenting with breathlessness

BackgroundDifferentiating heart failure from chronic obstructive pulmonary disease (COPD) in a patient presenting with breathlessness is difficult but may have implications for outcome. We investigated the prognostic impact of diagnoses of COPD and/or heart failure in consecutive patients presenting to a secondary care clinic with breathlessness.MethodsIn patients with left...

Long-term effects of device-guided slow breathing in stable heart failure patients with reduced ejection fraction

BackgroundSlow breathing (SLOWB) alleviates symptoms of chronic heart failure (HF) but its long-term effects are unknown. We examined the acute and long-term impact of device-guided breathing on hemodynamics and prognostic parameters in HF patients with reduced ejection fraction (HFrEF).Methods and resultsTwenty-one patients with HFrEF (23.9 ± 5.8%, SD ± mean) on optimal medical...

Value of the CHA2DS2-VASc score and Fabry-specific score for predicting new-onset or recurrent stroke/TIA in Fabry disease patients without atrial fibrillation

ObjectivesTo evaluate potential risk factors for stroke or transient ischemic attacks (TIA) and to test the feasibility and efficacy of a Fabry-specific stroke risk score in Fabry disease (FD) patients without atrial fibrillation (AF).BackgroundFD patients often experience cerebrovascular events (stroke/TIA) at young age.Methods159 genetically confirmed FD patients without AF...

Parameters of pulse wave velocity: determinants and reference values assessed in the population-based study LIFE-Adult

Aims and backgroundParameters of arterial stiffness such as pulse wave velocity (PWV) were recently proposed as independent risk factors of cardiovascular events. We analyse three PWV parameters in the large population-based study LIFE-Adult to identify risk factors, normal and reference values.Methods and resultsBrachial-ankle (ba), brachial-femoral (bf) and carotid-femoral (cf...

Driving ability after right-sided puncture of the common femoral artery during coronary angiography

Objectives/backgroundTo assess brake reaction time (BRT; key factor in driving ability) in patients receiving transfemoral coronary angiography (CAG). We assumed that patients would have a significantly impaired BRT after the procedure.MethodsA prospective, observational study design was applied. Consecutive patients undergoing right-sided transfemoral CAG as part of the clinical...

Inflammation and the risk of atrial high-rate episodes (AHREs) in patients with cardiac implantable electronic devices

IntroductionAtrial high-rate episodes (AHREs) are associated with an increased risk of developing atrial fibrillation and thromboembolism. The characteristics of ‘real world’ patients developing AHREs are poorly known.MethodsWe included 496 consecutive patients with cardiac implantable electronic devices (CIEDs). Primary endpoint was occurrence of AHREs, defined as > 175 bpm and...

Renal sympathetic denervation restores aortic distensibility in patients with resistant hypertension: data from a multi-center trial

Renal sympathetic denervation (RDN) is under investigation as a treatment option in patients with resistant hypertension (RH). Determinants of arterial compliance may, however, help to predict the BP response to therapy. Aortic distensibility (AD) is a well-established parameter of aortic stiffness and can reliably be obtained by CMR. This analysis sought to investigate the...