Analgesics such as non-steroidal anti-inflammatory drugs (NSAIDs) have gastrointestinal side effects and, particularly for local pain, topical dosage forms of these drugs are mainly preferred. The aim of this study was to develop meloxicam loaded niosomal hydrogel for enhanced transdermal and controlled drug delivery. Niosomal formulations were prepared by thin film hydration...
The specimens of the genus Ornithogalum L. (Asparagaceae) were collected from Kahramanmaras province in Southern Turkey between 2012 and 2013 during the PhD study. As a result of detailed examination and definitions of the collected specimens, it was determined that these specimens belonged to 19 species of two subgenera: “Subgenus Ornithogalum and Subgenus Beryllis’. The...
Pimpinella cypria Boiss (Apiaceae) is an endemic species of Turkish Republic of North Cyprus. It is locally known as ‘Cyprus-rocky anise’. Three species of the genus Pimpinella that are P. cretica Poir., P. peregrina L., and an endemic P. cypria grow in Cyprus. Specimens of P. cypria were collected from their nature habitats; St. Hilarion castle, and specimens were dried...
Lactobacillus plantarum is the most commonly used microorganism in industrial food fermentations. The multidrug resistance, bacteriocin production, various enzyme activities, probiotic properties and the resistance of the strain against bacteriophages, are important for application in industrial field. Microorganisms have developed various survival strategies in the evolutionary...
Ellman’s method is the most acknowledged procedure in order to determine the cholinesterase inhibitory potential of substances. It is a quick and high-throughput screening method. Therefore, it is widely used to measure the activities of original molecules and mixtures in aqueous solvents through a UV method. Regarding that many original or known substances as well as mixtures...
A headspace-solid phase microextraction (HS-SPME) procedure for isolation and investigation of volatile compounds in hybrid “limequat” and parents “Mexican lime and kumquat” fruits using Gas Chromatography-Mass Spectrometry (GC-MS) for the separation and identification of the volatiles was employed in the present study. Each of mature, fresh and whole fruits was freeze-dried, and...
Myrtus communis L., the common myrtle, is a plant which can be found in the Mediterranean and Middle East regions. The aim of the study is to evaluate the effects of myrtle on the human health. The fruit of myrtle has a unique flavour and can be in two different colours as black or white. Since ancient times, myrtle has been reported to be used in traditional medicine as a food...
“Ethyl 2,2-bis(4-fluorophenyl)-4-oxo-3,4-dihydro-2H-furo[3,2-c]chromene-3-carboxylate” is dihydro- furan-fused monocyclic heterocycles containing dihydrofurocoumarin framework. Compounds that include these core structures are especially important for drug discovery. Manganese(III) acetate has been used as an efficient oxidizing agent for the preparation of “ethyl 2,2-bis(4...
The diversity of vascular plants of Turkey was documented in the Flora of Turkey and the Eastern Aegean Islands edited by Prof. Peter H. Davis and published in nine volumes between 1965 and 1985. The identification of additional taxa has necessitated the publication of the supplementary volumes to the Flora of Turkey volume 10 in 1988, and the second supplemental volume, vol. 11...
Polygonaceae family mainly introduces itself with its stipules called ochrea. In Flora of Turkey, this family is indicated by eight genera that include Atraphaxis, Pteropyrum, Calligonum, Rheum, Oxyria, Polygonum, Rumex, Emex. This article emphasizes that the genus Polygonum and Persicaria are utterly different from each other. Full names and distributions of the species of...
Life expectancy, in general, is one of the crucial determinants of a country’s health status. This is particularly valid for the countries where industrialization has been improving. Turkey is one of the leading countries within this category, and there are limited number of studies about causal relationship between life expectancy and its determinants. Therefore, the aim of this...
“Ethyl 2,2-bis(4-fluorophenyl)-4-oxo-3,4-dihydro-2H-furo[3,2-c]chromene-3-carboxylate” is dihydro- furan-fused monocyclic heterocycles containing dihydrofurocoumarin framework. Compounds that include these core structures are especially important for drug discovery. Manganese(III) acetate has been used as an efficient oxidizing agent for the preparation of “ethyl 2,2-bis(4...
Paracetamol (PAR) tablets are commonly used over the counter formulations among the patients as analgesic and antipyretic. Therefore, the determination of the quality of these widely used tablets is important. On Northern Cyprus drug market, paracetamol formulations are provided various by pharmaceutical companies from different countries like Turkey, UK and local companies. In...
The COVID-19 pandemic is caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is continuing to spread around the world threatens the human health and has an impact on global economic crisis. As of 26th July 2020, no dedicated FDA-approved treatment and vaccine strategies have been confirmed for the treatment and prevention of COVID-19 patients. Many...
In the last few decades, the rate of the production of new antibiotic has declined significantly. This is mainly due to the high costs needed for both research and development processes. On the other hand, antibacterial resistance developed by bacteria against the already present antibiotics has been increasing extensively. Thus, finding alternatives to synthesize new...
The present study compared the total flavonoid content in ethanol and aqueous extracts of Indian Drosera and their in vitro immunomodulatory activities. None of the medicinally important compounds from this species has been quantified and compared previously. HPTLC method was used to quantify plumbagin and quercetin content in the ethanol extracts of three Indian Drosera species...
This study aimed to develop the formulation of effervescent tablets containing ferrous sulfate and ascorbic acid combination to increase intestinal iron absorption and reduce gastrointestinal side effects related to iron supplementation. In this study, the prototype formulation was calculated precisely and then prepared by three different methods for compression and evaluation...
Chlorinated phenols (i.e., totally 19 compounds from mono-chlorophenols to pentachlorophenol) have been synthesized in large amounts and used for diverse purposes within the last century. Their worldwide application in different areas also resulted in their accumulation within the environment. Therefore, it is always a topic of concern to investigate the biological effects of...
Traditional Uyghur Medicine (TUM) is widely used in Xinjiang Uyghur Autonomous Region in the east-west of China. TUM divided cardiovascular diseases according to causes and symptoms into several different types with different treatments to gain effective results. In this study, it was attempted to research anatomical characteristics of three frequently used herbs in...
A new, simple, fast and inexpensive method has been developed for the preconcentration of trace amounts of antimony(III) ions using nickel/nickel boride nanoparticles prior to their determination by hydride generation atomic absorption spectrometry. Optimization of the analytical parameters including initial pH, sorbent amount, contact time, sample volume, eluent type, and...
Oxidants are any agent capable of removing electron from another molecule in a course of a redox reaction. When it comes to biological systems free-radicals, especially reactive oxygen species (ROS) and reactive nitrogen species (RNS) are involved in oxidation reactions. Both endogenous and exogenous factors can contribute to free-radical formation. Fortunately, an endogenous...