Biological Trace Element Research

Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, ...

List of Papers (Total 718)

Assessment of Elements in Black Tea Infusions by Brewing Method in Terms of their Nutritional Value

Tea infusions contain many valuable bioactive compounds and elements. The research is aimed at examining them in terms of nutritional value and determining the optimal conditions for their preparation. The study determined the content of Ca, Cu, Fe, K, Mg, Mn, Na, Zn, and Al in infusions of black tea, including bagged and loose leaf. An atomic absorption spectrometer was used for...

Marketing of Freshwater and Marine Fish Species in Alexandria City, Egypt: Human Health Risk of Specific Metals

Fish intake may constitute a significant route by which humans are exposed to metals, especially people who depend on fish as a source of protein as Alexandrians. Therefore, this study aimed to investigate the metal contents in muscles in eight commonly consumed freshwater (Tilapia, Catfish, and Common Carp) and marine fish species (Emperors, Groupers, Mackerels, Silver Pomfret...

Silver Chloride Precipitation-limiting Factor for Accurate Silver Determination in Ag-accumulating Mushrooms After Nitric Acid Digestion

Wild-growing mushrooms (macromycetes, macrofungi) are capable of accumulating high amounts of trace elements, including noble metals. In a series of analytical experiments, this study focused on the problem of correct determination of Ag mass fractions in the biomass of Ag-accumulating mushrooms, Ag-hyperaccumulators in particular. A unique experimental setup enabled to compare...

Boron Prevents Oral Acrylamide Damage in Bone Marrow and Hematologic Parameters of Wistar Rats

The purpose of this study is to measure the effects of acrylamide (AA) on bone marrow and blood and the protective efficacy of boric acid (B) in rats. The animals were divided into five groups: control, B, low-dose B + AA, and high-dose B + AA. After the 15 th day of the experiment, their blood and bone marrow were harvested to be kept for hematological analyses. While white...

The Causal Relationship Between Zinc and Osteoarthritis: A Two-Sample Mendelian Randomization Study

There is a clear relationship between osteoarthritis (OA) and micronutrients. Excessive accumulation of micronutrients may play a negative role in aggravating the symptoms of OA. This study aims to sort out the causal relationship between micronutrients (zinc, copper, magnesium, vitamins A, C, E, D, B6, and B12, folic acid, iron, carotene, selenium, calcium, and potassium) and OA...

Molecular Changes Associated with Inflammation and Reproduction in Cadmium-Induced Testicular Toxicity: Mitigating Effect of Lactobacillus plantarum

Cadmium (Cd) is a dangerous heavy metal that causes toxicity in humans and animals. Various protective agents are being investigated to ameliorate the toxic effect of Cd. Lactic acid bacteria are promising as a protective agent because of their ability to remove heavy metals from contaminated products. The aim of this study was to evaluate the effects of Lactobacillus plantarum...

Urinary Copper Is Associated with Dyslipidemia, and This Association Is Mediated by Inflammation

Dyslipidemia is an important public health issue. Copper may influence lipid metabolism, possibly via inflammation, but the mechanisms remain unclear. This study aimed to assess the association between urinary copper concentrations and blood lipids (total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides...

Correlation of Serum Zinc Levels with Hepatic Encephalopathy Severity in Patients with Decompensated Liver Cirrhosis: A Prospective Observational Study from Egypt

A vital trace element, zinc, is involved in several metabolic and enzymatic functions, such as antioxidant defense and ammonia detoxification. Zinc metabolism is disturbed by liver cirrhosis, especially when it is decompensated, contributing to systemic complications, including hepatic encephalopathy (HE). This study aimed to assess serum zinc levels in patients with...

The Protective Effect of Boric Acid Against High Fructose-Induced Liver and Kidney Damage in Rats

This study aimed to determine the protective role of boric acid (BA) in high fructose (HF)-induced liver and kidney toxicity in a young rat model. High-fructose consumption causes serious damage to liver and kidney tissue in healthy individuals and contributes to the emergence of various metabolic diseases. Thirty-two healthy female Wistar albino rats (250–300 g weight and 3–4...

Investigation of the Effects of Selenium Against 4-Nonylphenol-induced Toxicity in Rat Testis

The study aims to investigate whether selenium (Se) has a protective role against testicular toxicity induced by 4-nonylphenol (4-NP) in rats and reduces oxidative damage. For this purpose, 30 adult male Sprague–Dawley rats (250–300 g/90 days old) were divided into five equal groups: control, sham control, Se, 4-NP, and 4-NP + Se. The trial lasted 48 days, with 4-NP administered...

The Role of SIRT1–BDNF Signaling Pathway in Fluoride-Induced Toxicity for Glial BV-2 Cells

Chronic fluorosis is often accompanied by neurological symptoms, leading to attention, memory and learning ability decline and causing tension, anxiety, depression, and other mental symptoms. In the present study, we analyzed the molecular mechanisms of SIRT1–BDNF regulation of PI3K–AKT, MAPK, and FOXO1A in F-treated BV2 cells. The cytotoxic effect of sodium fluoride (NaF) on BV2...

Synchrotron X-ray Fluorescence Microscopy Reveals Trace Elemental Indicators of Life History in Marsupial Teeth

As teeth develop, their mineralised composition is a bio-recorder of diet, environment, and growth. High-resolution elemental mapping provides a tool to reveal records of life history within teeth. The relative concentrations of a range of trace elements change between in utero development, birth, and weaning in eutherian mammals. Marsupials, however, have a different mode of...

Associations of Exposure to 56 Serum Trace Elements with the Prevalence and Severity of Acute Myocardial Infarction: Omics, Mixture, and Mediation Analysis

Several studies have reported associations between specific heavy metals and essential trace elements and acute myocardial infarction (AMI). However, there is limited understanding of the relationships between trace elements and AMI in real-life co-exposure scenarios, where multiple elements may interact simultaneously. This cross-sectional study measured serum levels of 56 trace...

Associations of Essential and Non-Essential Trace Elements’ Levels in the Blood, Serum, and Urine in Women with Premature Ovarian Insufficiency

Premature ovarian insufficiency (POI) is poorly understood, with causes identified in only 25% of cases. Emerging evidence suggests links between trace elements (TEs) and POI. This study is the first to compare concentrations of manganese (Mn), copper (Cu), zinc (Zn), selenium (Se), molybdenum (Mo), arsenic (As), cadmium (Cd), mercury (Hg), and lead (Pb) across urine, serum, and...

Coenzyme Q10 Attenuates Kidney Injury Induced by Titanium Dioxide Nanoparticles and Cadmium Co-exposure in Rats

This study examined the possible defensive role of coenzyme Q10 (CQ10) against the impact of cadmium (Cd) and titanium dioxide nanoparticle (TNP) exposure on rat kidneys. Distilled water (1 mL/rat), corn oil (1 mL/rat), 10 mg CQ10/kg b.wt, 50 mg TNP/kg b.wt, 5 mg Cd/kg b.wt, TNP + Cd, or TNP + Cd + CQ10 was administered orally to seven groups of 70 male Sprague Dawley rats for 60...

Nickel Sulfate-Induced GSIS Injury in MIN6 Cells by Activating the JNK Pathway Through Oxidative Stress

Nickel has an impact on human health, especially in the context of the new energy industries. Nickel’s influence on glycemia remains controversial, and the effects and mechanisms of nickel on islet function still need further exploration. MIN6 cells were treated with different concentrations of nickel sulfate (NiSO4) (0, 75, 150, and 300 µg/mL) for different durations (0, 12, 24...

The Preventive Effect of Zinc Sulfate against Olanzapine-Induced Testicular Toxicity in Male Rats

Male infertility is a complex and multifactorial clinical condition affecting a large population attributed to several factors, including perturbation in oxidative stress and the level of essential trace elements. Oxidative stress exerts multiple issues related to reproductive health, including male infertility, decreased sperm motility, sperm DNA damage, and an increased...