Background: The first 6 to 8 months of a human baby's life are among the most crucial periods of development. Mothers can enhance an infant's development by offering environments rich in appropriate stimuli. The study aimed to evaluate the effectiveness of motor developmental stimulatory training on mothers' motor development (fine and gross) in healthy, full-term, 6-month-old...
Background: Bone remodeling involves a balance between osteoblast-driven formation and osteoclast-mediated resorption, with disruptions leading to diseases like osteoporosis. Midazolam (MDZ), known for its sedative properties, has shown effects on cellular differentiation and hydroxyapatite formation in dental cells. However, its role in promoting osteogenic differentiation in...
Background: Circuit resistance training, beneficial to overweight individuals, combines aerobic and resistance exercises. This study aimed to investigate the effect of multi-joint circuit resistance training on serum adiponectin levels and lipid profiles in overweight women. Methods: Thirty sedentary overweight women (mean age of 34.48±4.304 years, mean weight of 81.17±9.137 kg...
Background: Self-care is defined as a strategy to adapt the events and stresses of life, which improves health and includes special activities that alleviate the symptoms of the disease. This study aimed to investigate the impact of a self-care program on the self-esteem of patients with type 2 diabetes mellitus (T2DM) attending rural health centers in Gorgan City in 2023...
Background: Brucellosis is a major health and economic problem in many parts of the world, including Iran. Therefore, this study aimed to investigate epidemiologic, demographic, and clinical aspects of the disease in Behbahan County during 2000-2021. Methods: In this descriptive cross-sectional study, we used a checklist that included epidemiologic, demographic, and clinical...
Background: Chrysin is a natural bioactive compound belonging to the flavonoid group. The pain-relieving effects of chrysin have been reported in several studies; however, the molecular mechanism underlying its analgesic properties remains unknown. In the present study, the analgesic effect of chrysin was investigated on the hypothalamic Calcitonin Gene-Related Peptide (CGRP) and...
Background: Hypothyroidism is typically associated with a decreased basal metabolic rate, reduced energy expenditure, and weight gain. Exercise training and Dorema Aucheri (DA) have been identified as beneficial therapeutic strategies within complementary health approaches. Skeletal muscle metabolism and fiber type are regulated by innervation and soluble factors, such as thyroid...
Background: Regular physical activity helps maintain health and improves the performance of various body systems. It is also recommended for managing many diseases and disorders, even after surgery. In this regard, the use of supplements may effectively synergize these benefits and promote faster recovery and cell repair. This study investigated the response of liver enzymes and...
Background: Obesity leads to neuronal apoptosis and cognitive impairment by increasing inflammation and oxidative stress. Although the beneficial role of exercise and antioxidant supplements have been reported separately, their interactive effect on neuronal apoptosis in obesity is still not well known. Therefore, this study aimed to investigate the effect of eight weeks of HIIT...
Background: The Coronaviridae family is responsible for coronavirus disease 2019 (COVID-19), which has become a global health threat. In Iran, the first confirmed case of COVID-19 was reported in Qom on February 19, 2020. The rapid spread of the virus led to a significant number of fatalities, highlighting the need for a detailed analysis of demographic, epidemiological, and...
Background: End-Stage Renal Disease (ESRD) patients under maintenance hemodialysis are at higher risk for COVID-19 and severe outcomes. This study aimed to investigate the association between ESRD patients who underwent maintenance hemodialysis at 5th Azar and Sayad Shirazi Hospital in Golestan Province in 2019 and their risk of contracting and experiencing severe outcomes from...
Background: Cefiderocol is a siderophore cephalosporin with unique cell-penetrating abilities against multidrug-resistant (MDR) Gram-negative bacteria, especially carbapenem-resistant strains. This study aimed to evaluate the prevalence and susceptibility profiles of Cefiderocol on carbapenem-resistant uropathogenic Escherichia coli and Klebsiella pneumoniae isolates among...
Background: Esophageal cancer is one of the most common cancers worldwide. Because this disease is usually diagnosed in advanced stages, its treatment is challenging and the survival rate of patients is relatively low. One of the parts that is disturbed in the tumor tissue of esophageal cancer is the tight connections between cells. Claudin-4 (CLDN-4) is one of the tight junction...
Background: Asthma is a chronic respiratory disease and a major public health problem globally. This study aimed to determine the prevalence of asthma and related symptoms in schoolchildren in Dezful city, southwest Iran. Methods: In this cross-sectional descriptive analytical study, the prevalence of asthma symptoms was measured using a randomized cluster sampling method among 2...
Background: Mitochondrial function is an integral part of glucose-stimulated insulin secretion in pancreatic β-cells and is a hallmark feature of cardiovascular disease. It may contribute to the pathophysiology of diabetic cardiomyopathy and atherosclerosis. This study aimed to investigate the effect of high-intensity interval training (HIIT) and moderate-intensity continuous...
Monoamine neurotransmitters, including serotonin, dopamine, histamine, and adrenaline/noradrenaline (epinephrine/norepinephrine), are key neuromodulators in the nervous system that influence complex behavioral and cognitive functions. They also affect peripheral tissues and inflammation, playing a crucial role in the biology of various malignancies, including breast cancer, the...
Background: The Ministry of Health has prioritized social health interventions to enhance the social capital within health systems. This study analyzes the implementation of Iran's Ministry of Health's social health policies based on Kingdon's model. Methods: This qualitative study, conducted in 2022, utilized Kingdon's (2003) model as the research framework. Data were collected...
Background: Severe coronavirus infections may lead to long-term effects, such as persistent lung dysfunction and residual involvement. This study aimed to evaluate pulmonary function tests (PFT) and chest computed tomography (CT) scans of severe COVID-19 intensive care unit (ICU) survivors one year after discharge. Methods: A cohort study was conducted, assessing spirometry and...
Background: Serotonin is a neurotransmitter with extensive physiological effects on the Central Nervous System (CNS) and various biological functions, including the regulation of immunity through 5-hydroxytryptamine receptors (5-HTRs) expressed by immune cells such as macrophages. Phenelzine, a medication used in managing treatment-resistant depression, acts as a potent monoamine...
Background: When metabolic demands increase due to an obesity-induced high-fat diet (HFD), mitochondrial function is impaired, production can increase, and oxidative stress occurs. This type of stress has been shown to play a key role in various pathological conditions such as heart disease, hypertension, diabetes, chronic kidney disease, and cancers. This study aims to evaluate...
Background: Insufficiency of omentin-1 and 25-hydroxyvitamin D serum levels is associated with obesity, which is known as a threat to health. Therefore, the aim of the present study was to examine the effect of eight weeks of Pilates exercise on the serum levels of 25-hydroxyvitamin D, omentin-1, and lipid profile in overweight women. Methods: In the present clinical study, 26...
Background: Resistance training and protein supplementation are known to increase protein synthesis and hypertrophy, primarily through the activation of the mTORC1 signaling pathway. However, mTORC1 activation in the kidneys can potentially lead to kidney disease. This study investigates the effects of eight weeks of resistance training combined with Spirulina platensis...
Background: Non-alcoholic steatohepatitis (NASH) is one of the prevalent metabolic diseases, and knowing its treatment methods is very important. This study investigates the effect of eight weeks of combined high-intensity interval training on intrahepatic FNDC5 protein and irisin in male rats with non-alcoholic steatohepatitis. Methods: In this study, 40 rats aged 6 to 8 weeks...
Background: The use of complementary medicine in healthcare is increasing rapidly. Therefore, the aim of the current study was to investigate the effect of eight weeks of high-intensity interval training and moderate-intensity continuous training with quercetin supplementation on the gene expression of FOXO1 and ATG5 in the liver of diabetic obese rats. Methods: In this...
Background: Oral cancer is the sixth most common cancer in the world and the third most common cancer in developing countries. Early detection of oral cancer can reduce mortality in several ways. The aim of the present study was to combine the quantitative results of various studies concerning serum and salivary microRNAs for early diagnosis of head and neck squamous cell...