Full-scale war in Ukraine has been going on for five years. The damage caused to the environment will remain for many years to come: it will take decades to stop negative climate change, soil degradation and biodiversity loss, as well as significant efforts to restore ecosystems that have been subjected to extremely heavy pressure. The objective: based on the analysis of literary...
Metabolic syndrome (MetS) is a complex condition which is characterized by a combination of metabolic and clinical abnormalities. It includes increased visceral fat mass, insulin resistance, hyperinsulinemia, and disorders in carbohydrate, lipid, and purine metabolism. These factors significantly contribute to the development of cardiovascular diseases and other related...
In a daily practical activity, general practitioners – family doctors (GP-FD) often have patients in whom anemia is the initial manifestation of a pathological process. In such cases, the severity and prognosis of the disease are largely determined by the underlying comorbidity, which may remain undiagnosed for a long time. Conducting a diagnostic search in such clinical...
Medical students’ knowledge of COVID-19 symptoms in children has been increasing since the World Health Organization declared the virus a pandemic. COVID-19 is an acute infectious respiratory disease. The objective: to evaluate medical students’ understanding of post-COVID-19 symptoms to raise awareness and help mitigate these symptoms in children. Materials and methods. The...
Osteoporosis (OP) is a global public health problem which is characterized by reduced bone strength and an increased risk of fractures. This article reviews the current evidence about the development of osteopenia and OP, early detection and diagnosis of bone disorders, as well as the possibilities and appropriateness of nutritional support for bone tissue. Systematic reviews...
Chronic pancreatitis (CP) is a common disease that significantly worsens the patients’ quality of life and requires a comprehensive approach to diagnosis and treatment. Often, CP is accompanied by chronic gastritis and/or duodenitis (CG / CD), which complicates the course of both pathologies. One of the main factors in the development of these diseases is Helicobacter pylori...
The objective: to evaluate the feasibility of using the synbiotic Active Flora Duo Plus in the treatment of patients with irritable bowel syndrome with diarrhea (IBS-D) and small intestinal bacterial overgrowth (SIBO). Materials and methods. The study involved 69 patients with SIBO against the background of IBS-D: men – 43.5%, women – 56.5% aged 23 to 72 years (mean age 43.6 ± 12...
The comorbidity course of chronic obstructive pulmonary disease (COPD) and chronic pancreatitis (CP) can exacerbate the clinical manifestations of both diseases and increases the frequency of relapses of the pathological process due to disturbances of hemocoagulation. The objective: to establish the features of the external respiratory function and the state of selected...
The objective: to increase the level of knowledge of primary healthcare professionals regarding the clinical and laboratory features of chronic myeloid leukemia (CML), with the aim of increasing vigilance for the timely diagnosis of the disease. A review of modern scientific literature was conducted with emphasis on the role of general practitioners and family physicians in...
Clinical trials (CTs) have traditionally focused on evaluating the efficacy and safety of medical interventions in controlled settings. However, the gap between their results and practical application in healthcare systems in different countries commands the need for better integration of research and clinical infrastructure. The objective: to analyze the modern approaches to the...
Taking into account the increase of diabetes mellitus (DM) prevalence, diabetic neuropathy remains one of the most important causes of neuropathology. The treatment of diabetic neuropathy with traditional western medicine protocols and drugs often remains unsuccessful, while Traditional Chinese Medicine (TCM) explains the pathogenesis of DM, its complications and impact on...
The objective: to determine the presence and level of anxiety disorders in patients with bronchial asthma (BA) depending on its control. Materials and methods. 78 patients with persistent BA of mild and moderate severity (average age – 42.7 ± 3.5 years; 35 were men and 43 were women), with uncontrolled BA, mild and moderate exacerbation, who consulted a family doctor were...
The issue of the quality of medical education in Ukraine has acquired nationwide significance. In the context of the COVID-19 pandemic, the full-scale war, and the rapid development of artificial intelligence, there is a growing need to adapt teaching approaches in medical universities to contemporary challenges, taking into account the current state of physicians’ professional...
Chronic constipation, traditionally considered as a functional gastrointestinal disorder, is increasingly recognized as a clinically significant cardiovascular risk factor. The current epidemiological studies and meta-analyses demonstrate a consistent association between constipation and an increased risk of major adverse cardiovascular events, heart failure, ischemic stroke...
The objective: to provide a summary of expert recommendations for the early detection and management of pancreatic exocrine insufficiency (PEI) in patients with diabetes mellitus (DM). The publication is based on materials and conclusions of the International Expert Advisory Council, convened on 28 November 2025, which included gastroenterologists and endocrinologists from...
The article "Cardiomyocyte Apoptosis as a Risk Factor for Ischemic Heart Disease Development (Literature Review)." published in issue №2 2025 has been retracted by decision of the Editorial Board after internal review revealed substantial textual borrowing from a foreign-language source without proper citation, constituting plagiarism and violating academic integrity standards...
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have revolutionized the treatment of type 2 diabetes (T2D), improving blood sugar control, reducing disease complications, and lowering mortality. These drugs were later approved for the treatment of multiple chronic diseases, including chronic kidney disease (CKD), atherosclerotic cardiovascular disease, and heart failure...
The post-crisis period following the COVID-19 pandemic and the war in Ukraine has revealed critical gaps in the capacity of primary care to address population mental health. In this context, mental health literacy (MHL) and digital health literacy (DHL) emerge as key frameworks for strengthening the role of family physicians as first-line providers of psychosocial support. This...
The article covers global approaches to understanding dyspepsia, as well as the complexities of its diagnosis and the selection of effective therapeutic strategies. Functional dyspepsia is a common functional gastrointestinal disorder caused by motility disturbances, increased visceral hypersensitivity, altered mucosal permeability, and other factors. The absence of a single...
Allergic fungal rhinosinusitis (AFRS) is classified as a primary, localized, with Th2-inflammatory response rhinosinusitis. It is characterized by the presence of nasal polyps, production of typical thick eosinophilic mucin, and expansive changes in the affected paranasal sinuses. The diagnosis is based on the diagnostic criteria which were established by John P. Bent, and...
The prevalence of Helicobacter pylori (H. pylori) infection varies across populations and geographic regions. However, a comprehensive review of prevalence in Ukraine has not been conducted. The objective: to estimate the pooled prevalence of H. pylori among children and to identify factors associated with H. pylori infection in Ukraine. Materials and methods. We performed a...
The objective: to optimize the management of patients with chronic myeloid leukemia (CML) by identifying the characteristics of intoxication syndrome based on laboratory parameters evaluation and their further corrections. Materials and methods. This prospective cohort study enrolled 97 participants, in which 77 patients with CML were divided according to diseases stages (chronic...
Pathology of the respiratory system continues to occupy a leading place among diseases of childhood, especially in economically poor countries. One of the most common respiratory diseases is community-acquired pneumonia (CAP). According to the WHO, one child dies every 43 seconds from pneumonia worldwide. Pneumonia affects the lung tissue with the development of respiratory...
Helicobacter pylori (H. pylori) infection remains one of the most common chronic bacterial infections worldwide, which is associated with the development of chronic gastritis, peptic ulcer disease of the stomach and duodenum, MALT (Mucosa-Associated Lymphoid Tissue) lymphoma, and gastric cancer. The success of eradication therapy largely depends on antibiotic resistance...
The objective: to evaluation of the efficacy and safety of β-adrenoblocker esmolol to treat postoperative arterial hypertension (PAH) in patients with ischemic heart disease. Materials and methods. The study included 30 patients (45–78 years, mean age – 60.5 ± 17.3 years) who underwent coronary artery bypass grafting surgery with continuous blood purification. PAH developed...