Strategies for detecting microRNA (miRNA) via rolling circle amplification (RCA), combined with additional signal amplification techniques, have shown promising potential. However, achieving rapid, sensitive, and precise detection of target miRNA remains a major challenge in clinical diagnostics. The inherent limitations of insufficient selectivity have impeded the advancement of...
Federated learning (FL) enables collaborative model training across multiple institutions while preserving data privacy. However, conventional encryption techniques used in FL remain vulnerable to quantum attacks, raising concerns about the security of model update transmissions. To address this, we propose a quantum-safe federated learning framework, which integrates a post...
Allanite is a LREE-rich epidote-group mineral, and a potential chronometer for the greenschist-facies metamorphism. However, owing to the metamict nature of allanite, it is extremely difficult to secure sufficient amounts of mineral separates from metapelites. Thus, we applied the U–Pb step-leaching (UPbSL) technique to determine the metamorphic age of allanite inclusions in...
Conventional chemotherapy is often constrained by the toxic effects of anticancer drugs, particularly in drug-resistant tumours requiring high doses for efficacy. This challenge underscores the need for innovative strategies to deliver anticancer medications effectively while minimizing systemic toxicity. Ultrasound-assisted drug delivery has emerged as a promising approach...
Amomum villosum Lour. is an essential plant for both consumption and healing purposes. Among all the regions in China where A. villosum is grown, Yangchun City is widely regarded as the most ideal habitat for this plant. However, there were rare studies that explored the differential metabolites between Yangchun and other regions of A. villosum fruits. The current study analyzed...
Altering the electronic structure and surface functional groups of the pure-elemental quantum dots by heteroatom doping is a relatively new approach to enhance the intensity of the weak chemiluminescence (CL) systems and fabricate the more sensitive sensors for the determination of the analytes. The current study is focused on improving the CL behavior of sulfur quantum dots...
Accurate and reliable detection of Pseudomonas aeruginosa (P. aeruginosa) is crucial for the early diagnosis of infections. We present a simple technique for the sensitive and reliable detection of P. aeruginosa by combining aptamer-based target recognition with self-priming induced conformation of split G-quadruplex. This approach employs an aptamer sequence for precise target...
Single-cell multi-omics technologies have brought a groundbreaking transformation to the field of cell biology by uncovering the intricate connections between an organism’s genetic blueprint and its observable traits. While all cells in an organism share the same genetic makeup, variations in gene expression shape their physiological characteristics. Single-cell RNA sequencing...
This study investigates the thermal effects on europium(III)-sorbed bentonite, a montmorillonite-rich clay, with focuses on the structural changes in montmorillonite and the leachability of Eu(III). Thermogravimetric analysis shows greater water-related weight loss in Eu(III)-sorbed bentonite compared to Na-bentonite, likely due to the expanded c-spacing of montmorillonite and...
The high reactivity of mafic minerals, such as olivine and pyroxene, plays a crucial role in controlling the global magnesium (Mg) flux and its isotopic composition. This study investigates the mechanisms and extent of Mg isotope fractionation during the dissolution of these minerals under far–from–equilibrium conditions. These findings provide valuable insights into the behavior...
Silicate mineral weathering, particularly involving Mg-bearing minerals like hornblende and chlorite, plays a crucial role in the global geochemical cycle of magnesium. This process is intrinsically linked to carbon sequestration and climate regulation. Mg isotopes offer a valuable tool to investigate the complex interplay between climate and silicate weathering. In this study...
When analyzing the Free Induction Decay (FID) signal produced by nuclear magnetic resonance (NMR) spectroscopy, Fourier transforms (FT) are used to decompose time-domain signals arising from nuclear interactions. This transformation enables the extraction of frequency-domain information, allowing for the recognition of patterns within the generated NMR spectra. Most modern NMR...
The human norovirus (abbreviated as HuNV) is the most common agent responsible for acute viral gastroenteritis. Despite being recognized as a water-borne pathogenic virus for a long time, the cellular tropism of norovirus has not yet been clearly explained. The main reason is the lack of appropriate cell culture and animal model systems for HuNV infection. Murine norovirus...
Development of rapid and simple detection method holds great significance for the prevention and control of Staphylococcus aureus. Herein, the SELEX method was utilized to screen new aptamers for S. aureus. The double aptamers combined recognition target strategy were adopted to enhance specificity, and magnetic bead target enrichment and the rolling circle amplification strategy...
This study introduces a groundbreaking approach in sports science through the development of silicon nanoparticle-enhanced patches for real-time sweat analysis in athletes. Central to this innovation is the synthesis of silicon nanoparticles (SiNPs) with a 60 nm average diameter, ensuring uniformity and effectiveness in sweat monitoring applications. The patches demonstrate...
The phytocompounds found in medicinal plants attribute therapeutic values to the plants. However, when medicinal plants undergo different processes, such as crushing, grinding, boiling, and heating, the fate of phytocompounds is unclear. During these processes, phytocompounds may degrade, decompose, or even undergo molecular rearrangement, which results in a decrease or complete...
In this study, a rapid, sensitive and accurate analytical method was optimized for the determination of trace levels of cadmium (Cd) by flame atomic absorption spectrophotometry (FAAS) after antimony oxide nanoparticles (AO-NPs)-based dispersive solid-phase extraction (DSPE). The AO-NPs were synthesized with a specific microwave temperature program, and they exhibited high purity...
Meteorological and edaphic factors significantly affect the first flush metabolite composition of Darjeeling tea, impacting flavor, nutrition, and customer preferences. The Camellia sinensis var. sinensis grown in the Darjeeling hills was sampled at different stages of processing. 75 metabolites were identified using a GC/MS-based metabolomic and chemometric technique. The study...
The electrochemical nucleation of MoS2 from a mixture of sodium molybdate dihydrate (Na2MoO4·2H2O) and sodium sulphide (Na2S·xH2O) aqueous solution on Cu substrate has been investigated. The nucleation and formation of molybdenum sulphide were investigated employing cyclic voltammetry and chronoamperometry studies. The experimental i–t curves observed at various overpotentials...
The present work is aimed at the synthesis of aluminum oxide nanoparticles (AlONPs) using the seed extract of Carica papaya. The aluminum oxide nanoparticles were evaluated using X-ray diffraction (XRD), Fourier transforms infrared (FTIR), field emission scanning electron microscopy (FESEM), energy-dispersive X-ray (EDX), ultraviolet–visible (UV–Vis) spectrophotometer, and zeta...
The accurate and dynamic monitoring of osteosarcoma, one of the most prevalent cancers, has a substantial impact on the quality of life of numerous individuals. This study proposes a sample, sensitive, and portable approach to miRNA detection that integrates a catalytic hairpin assembly (CHA) circuit with self-priming mediated chain extension. This method employs CHA as a protein...
The catalytic hairpin assembly (CHA)-based miRNA detection methods have garnered significant attention due to their simplicity and acceptable amplification efficiency. However, these methods necessitate improved sensitivity. In this work, we present a colorimetric and ultrasensitive approach for the detection of cancer-related miRNAs which is initiated by CHA-mediated nicking...
Iodine and bromine play central roles in polar atmospheric chemistry: iodine influences the atmospheric oxidative capacity and can generate cloud condensation nuclei, while bromine participates in ozone depletion reactions, known as bromine explosions. Here we present a very sensitive analytical method for Br and I speciation by coupling the ion chromatography system (IC) with an...
Determination of high sulfur content in sulfide minerals is crucial for various applications, including geochemistry, mining, and environmental monitoring. While inductively coupled plasma optical emission spectrometry (ICP-OES) is the preferred method for sulfur analysis, conventional sample preparation techniques often fall short when dealing with high sulfur concentrations...
Sertraline is used as an antidepressant drug for the treatment of psychiatric disorders, including anxiety and depression. In the current study, a simple and effective method was developed for the sensitive monitoring of sertraline in water samples using a GC–MS system. The spray-assisted droplet formation liquid-phase microextraction (SADF-LPME) method was used as a sample...