Osteoarthritis (OA) is a common degenerative joint disorder associated with aging, marked by chondrocyte senescence, cartilage degradation, and chronic inflammation. Although cellular senescence significantly contributes to OA progression, the molecular mechanisms governing this process are not fully understood. Interleukin-1 receptor-associated kinase 3 (IRAK3) acts as a...
Adipose-derived stem cell exosomes (ADSCs-Exos) enhance endometrial carcinoma (EC) cell proliferation, migration, and invasion. Mechanistically, ADSCs-Exos downregulate MAGED4B and CDH1, reduce E-cadherin expression, and upregulate vimentin, promoting epithelial-mesenchymal transition (EMT). Overexpression of MAGED4B reverses these effects and inhibits malignant behaviors...
Photodynamic therapy (PDT) offers a promising treatment option for nasopharyngeal carcinoma (NPC); however, intrinsic and adaptive resistance remains a major clinical limitation. Autophagy has emerged as a key cytoprotective mechanism in therapy resistance, yet the critical regulatory nodes governing PDT responses in NPC are incompletely defined. A curated set of 1206 autophagy...
Salidroside (SAL), a major bioactive compound derived from Rhodiola rosea L., exhibits diverse pharmacological activities, including anti-tumor, anti-inflammatory and cardiovascular protective effects. Arterial calcification is a prevalent vascular pathology characterized by the osteogenic differentiation of vascular smooth muscle cells (VSMCs). However, the potential role of SAL...
Asporin, a small leucine-rich proteoglycan encoded by the ASPN gene, is a vital player in cancer biology. Its oncogenic role in gastric cancer (GC) has been well-documented, particularly in promoting proliferation, apoptosis resistance, and migration/invasion. Nevertheless, ASPN’s function in regulating glycolysis and stemness in GC cells remains underexplored. Here, we initially...
The use of animal models plays a crucial role in advancing our understanding of human diseases, providing valuable insights into pathophysiological mechanisms and supporting the development of innovative therapeutic strategies. Among the available models, porcine models have been recognized as particularly relevant due to their anatomical, genetic, and physiological similarities...
Fluoride is commonly used in dentistry to prevent dental caries, however, excessive exposure may pose risks to soft tissues, particularly the kidneys, which are responsible for approximately 60% of fluoride excretion. Diabetic nephropathy, a major complication of diabetes mellitus, may share pathogenic pathways with fluoride-induced renal toxicity. However, the combined effects...
Pimpinella brachycarpa has been used in food and traditional herbal medicine for its anti-inflammatory and antimicrobial properties. This study evaluated the therapeutic potential of P. brachycarpa extract (PBE) in a rat model of ligature-induced periodontitis and identified its active compounds, such as green tea catechin (GTC), chlorogenic acid (CGA), and their combination (MIX...
This manuscript presents a letter to the editor addressing the study by Lv et al. (J Mol Histol 56(2):129, 2025), which identifies PDZ-binding kinase (PBK) as a diagnostic and prognostic biomarker for hepatocellular carcinoma (HCC). While commending the article’s comprehensive approach—including bioinformatics integration and validation of PBK's role in immune infiltration and...
Objective Hypoxic ischaemic (HI) damage is a major cause of white matter damage (WMD) in the brains of newborns, especially preterm infants; early neuroprotection is essential to improve cognitive outcomes. This study aimed to investigate the effect of melatonin on nerve injury by inhibiting mitochondrial autophagy. Methods We established a neonatal WMD model through HI induction...
Robinin (RB) is an accepted antioxidant herbal product with known cardio-protective activity. To explore the anti-oxidative potential of RB in treating myocardial ischemia or reperfusion (MI/RI) damage in rats after inducing hypercholesterolemia (HC). HC was induced by administering cholesterol (2%) to rats for eight weeks. The rats were given RB (50 mg/kg bw) for the last two...
This study aims to explore the role of N6-methyladenosine (m6A) RNA modification in regulating Cuproptosis in steroid-induced osteonecrosis of the femoral head (SONFH), providing insights into its underlying mechanisms and therapeutic targets. Gene expression profiles from both human (GSE123568; 30 SONFH patients and 10 controls) and rat femoral head samples (GSE26316; 3 SONFH...
Background Chronic kidney disease (CKD) is an epidemic with higher cardiovascular risk, and this pathology involves renal injury and fibrosis. Kurarinone (KAR) has anti-inflammatory and anticancer effects, which can regulate immune responses and macrophage polarization. This study aimed to investigate the effect of KAR on model-induced unilateral ureteral obstruction (UUO) renal...
Pesticides are used as insecticides in agriculture. Lupeol (LUP) is a dietary triterpene with antioxidant effects. This experiment aimed to investigate the effects of LUP against testicular pesticides toxicity via histological and biochemical findings. Wistar albino rats were used. Control, corn oil, malathion (MAL), chlorpyrifos (CPF), tebuconazole (TEB), LUP, MAL + LUP, CPF...
Lung cancer remains the most prevalent carcinoma with a high mortality rate, yet the underlying mechanisms driving pulmonary neoplasia and disease progression are not fully understood. In our study, we conducted a comprehensive analysis of the transcriptome profiles and clinicopathological characteristics of 515 patients diagnosed with non-small cell lung cancer (NSCLC) from the...
PIWI-interacting RNAs (piRNAs) play an important role in cancer development and progression. Although recent studies had advanced our understanding of the functions of various piRNAs in cancer, the specific role of piR-38736 in gastric cancer remained poorly understood. This study aimed to investigate the clinical significance and underlying mechanisms of piR-38736 in gastric...
Diagnostic and prognosis of hepatocellular carcinoma (HCC) remain major challenge in clinic. This study aimed to explore a gene signature for diagnosis and prognosis prediction of HCC followed by mechanism investigation. Differentially expressed genes (DEGs) in HCC were screened using TCGA. With specific formula, clinic features of prognosis associated DEGs were calculated to...
Coronary artery calcification (CAC) is a common complication in patients with stable ischemic heart disease (SIHD). However, the early diagnosis and understanding of the pathogenesis of CAC in SIHD patients remain underdeveloped. This study aimed to analyze aberrant alterations in the serum proteome of SIHD patients, as well as SIHD patients with severe CAC (CAC_SIHD), and to...
We examined whether combined exogenous mitochondria (ExMito) and cellular prion protein overexpression (Ove-PrPC) in adipose-derived mesenchymal stem cell (Ove-PrPC in ADMSCs) therapy is superior to a single therapy for protecting the brain against intracranial hemorrhage (ICH) in rats. In vitro, compared with the control group, ExMito transfusion into recipient cells (i.e., N2a...
Acute myocardial infarction (AMI) is a leading cause of heart failure, often accompanied by myocardial fibrosis (MF), characterized by excessive extracellular matrix accumulation. Endothelial-to-mesenchymal transition (EndMT) plays a key role in MF progression post-AMI. Neuregulin-1 (NRG-1), a growth factor with cardioprotective properties, has emerged as a potential therapeutic...
Chemotherapy remains the primary therapeutic strategy for most tumors, particularly those at advanced stages with distant metastases and resistance to molecularly targeted therapy or immunotherapy. There are many manifestations of chemotherapy-induced gastrointestinal toxicity (CIGT), including chemotherapy-induced diarrhea (CID) and chemotherapy-induced constipation (CIC...
SARS-CoV-2 E and 3a proteins are important for the assembly, budding, and release of viral particles. These two transmembrane proteins have been implicated in forming channels in the membrane that allow the transport of ions to favor viral replication. During an active infection, both proteins generally localize to the endoplasmic reticulum (ER), ER-Golgi intermediate compartment...
This study tested whether combined ceftriaxone and adipose-derived mesenchymal stem cells (ADMSCs) would defend the spinal cord against acute spinal infection (ASI) in rodent. Adult-Male-SD rats were grouped into groups 1 (SC)/2 (ASI)/3 (ASI + ceftriaxone from days 2 to 28 after ASI induction)/4 (ASI + allogenic ADMSCs from day 2 for a total of 3 doses/3 consecutive intervals by...