Anticoagulation Activity of the Modified Poly(vinyl alcohol)

Heung-Jae Chun, Jae-Jin Kim, Kea Yong Kim

Cross-linked blendmers of the poly(vinyl alcohol) (PVA) with substituted anion have been prepared. Possibilities of the samples for the usage as biomaterial were estimated by measuring the tensile strength and elongation under dry and wet condition, and studied by in-vitro blood tests. And the contact angle of the samples were also investigated in order to examine the surface properties. The most improved anticoagulation activity was observed in XSC-3 which is a blendmer of 60 wt% of the sulfonated PVA and 40 wt% of the carboxymethylated PVA.