Isolation and Identification of the Icosalides—Cyclic Peptolides with Selective Antibiotic and Cytotoxic Activities
The Journal of Antibiotics, Aug 2006
Three cyclic peptolides have been isolated from two different fungal species and their structures determined. Icosalides A1 (1a), A2 (1b), and B (1c) each contain two serine and two leucine amino acid residues and incorporate two fatty acid moieties as part of the central twenty-member ring. 1a contains L-serine and both D- and L-leucine residues, while 1b and 1c contain only L-amino acid residues. Icosalide A1 displays antimicrobial activity against Streptococcus pyogenes, S. pneumoniae (Felton), and Enterococcus faecalis. Icosalides A2 and B are cytotoxic to replicating MDCK cells.
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Article home page: https://www.nature.com/articles/ja200668
Christie Boros, Cameron J Smith, Yelena Vasina, Yongsheng Che, Alissa B Dix, Blaise Darveaux, Cedric Pearce. Isolation and Identification of the Icosalides—Cyclic Peptolides with Selective Antibiotic and Cytotoxic Activities, The Journal of Antibiotics, 2006, pp. 486-494, Issue: 59, DOI: 10.1038/ja.2006.68
