AURORA: Bariatric surgery registration in women of reproductive age - a multicenter prospective cohort study

Jans et al. Archives of Public Health 2015, 73(Suppl 1):P45 http://www.archpublichealth.com/content/73/S1/P45 ARCHIVES OF PUBLIC HEALTH POSTER PRESENTATION Open Access AURORA: Bariatric surgery registration in women of reproductive age - a multicenter prospective cohort study Goele Jans1*, Christophe Matthys2, Matthias Lannoo2, Bart Van der Schueren2, Bruno Dillemans3, Luc Lemmens4, Jean-Pierre Saey5, Yves Van Nieuwenhove6, Ben De Becker7, Pascale Grandjean5, Hilde Logghe8, Kristien Roelens6, Anne Loccufier3, Johan Verhaeghe2, Roland Devlieger2 From Methods in Epidemiology Symposium Leuven, Belgium. 17 September 2015 Introduction Bariatric surgery has become the most successful longterm treatment of severe obesity, illustrated by almost 469,000 performed procedures worldwide in 2013. Women aged 18-45 years represent the major part of the bariatric population. A long-term follow-up, starting before surgery until a subsequent pregnancy and postpartum period, is needed to study reproduction outcomes in order to fill knowledge gaps and provide a scientific base for clinical guidelines. Methods/design This multicenter prospective cohort study aims to examine the impact of bariatric surgery on reproduction outcomes. Women aged 18-45 years are invited to participate at 4 possible inclusion moments: 1) pre-operatively, 2) postoperatively, 3) before 15 weeks of pregnancy and 4) in the early postpartum period. Depending on the time of inclusion, data is collected pre-operatively, 3 weeks and 3, 6 and 12 months post-operatively and during the first, second and third trimester of pregnancy, at delivery, weekly until 6 weeks postpartum and finally at 6 months postpartum. Online questionnaires (contraceptive use, sexuality, menstrual cycle, intention of becoming pregnant, diet, physical activity, psycho-social health and nutritional supplement intake) are distributed on the different measuring moments. Fasting blood samples are collected to determine the nutritional status, measuring vitamin A, D, E, K, B-1, B12 and folate, albumin, total protein, hemoglobin, hematocrit, iron, ferritin, transferrin (saturation), prothrombin time, activated partial prothrombin time, magnesium, calcium and zinc. Participants will be weighted every measurement point. Ultrasounds and pregnancy outcomes are reported every trimester of pregnancy. Breast milk samples of 5 ml are collected weekly from after birth until the routine 6 week postpartum consultation in order to examine the milk macronutrient composition. Conclusion AURORA is a unique multicenter cohort study and might be of great value for the development of guidelines and recommendations in order to optimize clinical care in these women. Authors’ details 1 KU Leuven, Leuven, Belgium. 2KU Leuven/University of Leuven, Leuven, Belgium. 3AZ St-Jan, Bruges, Belgium. 4AZ St-Nikolaas, St-Niklaas, Belgium. 5 CHR Mons-Hainaut, Mons-Hainaut, Belgium. 6UZ Gent, Gent, Belgium. 7AZ St-Augustinus, Wilrijk, Belgium. 8AZ St-Lucas, Bruges, Belgium. Published: 17 September 2015 doi:10.1186/2049-3258-73-S1-P45 Cite this article as: Jans et al.: AURORA: Bariatric surgery registration in women of reproductive age - a multicenter prospective cohort study. Archives of Public Health 2015 73(Suppl 1):P45. 1 KU Leuven, Leuven, Belgium Full list of author information is available at the end of the article © 2015 Jans et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http:// creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/ zero/1.0/) applies to the data made available in this article, unless otherwise stated.  (...truncated)