Slc4a10; sodium-dependent chloride-bicarbonate exchanger

Science-Business eXchange, Jan 2008

Studies in mice showed that antagonizing Slc4a10 could treat epilepsy or other neurological conditions characterized by pH or electrolyte imbalance.

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Slc4a10; sodium-dependent chloride-bicarbonate exchanger

the distillery This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Neurology Epilepsy Slc4a10; sodiumdependent chloride-bicarbonate exchanger SciBX: Science–Business eXchange Studies in mice showed that antagonizing Slc4a10 Not applicable could treat epilepsy or other neurological conditions characterized by pH or electrolyte imbalance. Choroid plexus epithelial cells from Slc4a10 knockout mice showed defects in intracellular pH regulation, which is associated with neuronal excitability. The mice also had reduced brain ventricle volume and better protection against fatal epileptic seizures compared with wild-type animals. Next steps include finding a specific inhibitor of Slc4a10. Copyright © 2008 Nature Publishing Group Jacobs, S. et al. Proc. Natl. Acad. Sci. USA; published online Dec. 28, 2007; doi: 10.1073/pnas.0705487105 Contact: Christian A. Hübner, Friedrich-Schiller-Universität, Germany e-mail:  (...truncated)


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Slc4a10; sodium-dependent chloride-bicarbonate exchanger, Science-Business eXchange, 2008, pp. 18, Volume 1, Issue 1, DOI: 10.1038/scibx.2008.18