A-20 Metabolic Syndrome and Executive Functioning in Young, Middle-Aged, and Older Adults

Archives of Clinical Neuropsychology 34 (2019) 860–1099 Abstract Poster Session A NEUROPSYCHOLOGICAL DOMAINS: EXECUTIVE FUNCTIONS A-20 Metabolic Syndrome and Executive Functioning in Young, Middle-Aged, and Older Adults Slonim T, Haase-Alasantro L, Murphy C Objective: Metabolic syndrome (MetS) is associated with increased rates of mortality and increased risk for developing dementia. Changes in brain structure and executive functioning have been reported within the literature. However, research examining cognitive performance in individuals with metabolic syndrome focuses primarily on older cohorts. As such, the effect of metabolic syndrome on cognitive functioning earlier in the lifespan is unclear. This research examined neuropsychological test performance and self-report measures in young, middle-aged, and older adults with and without MetS. Method: Participants (n = 128) were categorized by age and metabolic status as follows: Young: n = 42, 52.4% Metabolic; Middle-Age: n = 41, 56.1% Metabolic; Older: n = 45, 51.1% Metabolic. Participants were administered the following cognitive assessments as part of a larger study: Delis-Kaplan Executive Function System (DKEFS) Color-Word Interference Test and Trail Making. Multivariate analyses of variance were used to examine the relationship between age group, metabolic status, and cognitive performance. Results: As expected, older adults performed more poorly than young and middle-aged adults across neurocognitive assessments (p < .05). MetS adults performed more slowly on Color-Word Interference: Inhibition [F(1,114) = 5.26, p = .024, η2 = .05]; however, there were no additional significant differences between groups on cognitive tests in this sample size. Conclusions: These findings suggest that aspects of inhibition might be impaired in MetS adults. Future studies aimed at investigating relationships between metabolic risk factors and inhibition may provide insight into effective intervention targets to delay or prevent metabolic syndrome. © The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: . doi:10.1093/arclin/acz034.20 Wednesday, November 13, 2019 5:30 pm – 7:00 pm  (...truncated)