Retraction: MMP-2 siRNA Inhibits Radiation-Enhanced Invasiveness in Glioma Cells

RETRACTION Retraction: MMP-2 siRNA Inhibits RadiationEnhanced Invasiveness in Glioma Cells The PLOS ONE Editors After this article [1] was published, concerns were raised about the following figures: • In Fig 3, the U-251/p-SV and U-87/p-SV panels appear similar, as do the U-87/mock and U87 mock/Irrad (8Gy) panels. • In Fig 4, there appears to be overlap between the following panels: � U-251/mock (lower left) and U-251/mock/Irrad (8Gy) (upper right); � U-251/p-SV (left side) and U-251/mock/Irrad (8Gy) (right side); � U-251/p-MMP-2/2Gy (upper) and U-251/p-MMP-2/4Gy (lower). • In Fig 5B, similarities were noted between bands in different lanes for each of the GAPDH panels. • In Fig 6B, there appears to be overlap between the following panels: � [row 1] U-251/p-MMP-2/2Gy and U-251/p-MMP-2/4Gy; � [row 2] U-251/mock, U-251/p-MMP-2/6Gy, and U-251/p-MMP-2/8Gy; � [row 2] U-251/p-MMP-2/2Gy and U-251/p-MMP-2/4Gy; a1111111111 a1111111111 a1111111111 a1111111111 a1111111111 OPEN ACCESS Citation: The PLOS ONE Editors (2020) Retraction: MMP-2 siRNA Inhibits Radiation-Enhanced Invasiveness in Glioma Cells. PLoS ONE 15(1): e0228689. https://doi.org/10.1371/journal. pone.0228689 Published: January 29, 2020 Copyright: © 2020 The PLOS ONE Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. � [row 4] U-87/p-MMP-2/0Gy and U-87/p-MMP-2/8Gy. • In Fig 6C, it is difficult to confirm the integrity of the blot images as the background appears uniformly white in most cases. In light of the above concerns that call into question the integrity and reliability of the published results, the PLOS ONE Editors retract this article. DA did not specify their position on this decision. The other authors either could not be reached or did not respond directly. Note, the U-87 cell line from ATCC was reported in 2016 to be misidentified but likely of glioma origin [2]. References 1. Badiga AV, Chetty C, Kesanakurti D, Are D, Gujrati M, Klopfenstein JD, et al. (2011) MMP-2 siRNA Inhibits Radiation-Enhanced Invasiveness in Glioma Cells. PLoS ONE 6(6): e20614. https://doi.org/10. 1371/journal.pone.0020614 PMID: 21698233 2. Allen M, Bjerke M, Edlund H, Nelander S, Westermark B. (2016) Origin of the U87MG glioma cell line: Good news and bad news. Sci Transl Med. 8(354):354re3. https://doi.org/10.1126/scitranslmed. aaf6853 PMID: 27582061 PLOS ONE | https://doi.org/10.1371/journal.pone.0228689 January 29, 2020 1/1  (...truncated)