Incidence of adverse reaction in blood donation: a systematic review.

Am J Blood Res. 2020; 10(5): 145–150. Published online 2020 Oct 15. PMCID: PMC7675132 PMID: 33224558 Incidence of adverse reaction in blood donation: a systematic review Moslem Taheri Soodejani,1 Ali Akbar Haghdoost,2 Maryam Okhovati,3 Farzaneh Zolala,2 Mohammad Reza Baneshi,4 Abbas Sedaghat,5 and Seyyed Mohammad Tabatabaei6,7 Moslem Taheri Soodejani 1 Research Center of Prevention and Epidemiology of Non-Communicable Disease, Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran, Find articles by Moslem Taheri Soodejani Ali Akbar Haghdoost 2 HIV/STI Surveillance Research Center, WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran, Find articles by Ali Akbar Haghdoost Maryam Okhovati 3 Medical Library and Information Sciences Department, Faculty of Management and Information Science, Kerman University of Medical Sciences, Kerman, Iran, Find articles by Maryam Okhovati Farzaneh Zolala 2 HIV/STI Surveillance Research Center, WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran, Find articles by Farzaneh Zolala Mohammad Reza Baneshi 4 Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran, Find articles by Mohammad Reza Baneshi Abbas Sedaghat 5 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran, Find articles by Abbas Sedaghat Seyyed Mohammad Tabatabaei 6 Department of Medical Informatics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, 7 Clinical Research Development Unit, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran, Find articles by Seyyed Mohammad Tabatabaei Author information Article notes Copyright and License information Disclaimer 1 Research Center of Prevention and Epidemiology of Non-Communicable Disease, Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran, 2 HIV/STI Surveillance Research Center, WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran, 3 Medical Library and Information Sciences Department, Faculty of Management and Information Science, Kerman University of Medical Sciences, Kerman, Iran, 4 Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran, 5 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran, 6 Department of Medical Informatics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, 7 Clinical Research Development Unit, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran, Address correspondence to: Seyyed Mohammad Tabatabaei, Department of Medical Informatics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Tel: +989153082261; E-mail: Received 2020 Jun 5; Accepted 2020 Aug 17. AJBR Copyright © 2020 Abstract There are a lot of reports related to adverse reactions post blood donation. The present study is designed to investigate the incidence of adverse reactions in blood donation around the world. This research was conducted through searching databases such as PubMed, Web of Science, Scopus, EmBase, Ovid, as well as the specialized journal of TRANSFUSION without any time limit by using the keywords including “Adverse Event”, “Adverse Effect”, “Adverse Reaction”, “Complication”, “Side Effect”, “Vasovagal Reaction”, “Local Reaction”, “General Reaction”, “Allergic Reaction”, “Blood Donor”, and “Blood Donation”. In the initial search, 7054 documents were found, of which 2517 duplicates were excluded. After screening the remaining 4,537 documents, 97 one were reviewed for quality assessment, of which 30 with the appropriate quality were selected for the review process. The results of the study showed that the reactions caused by blood donation are very different. Most reactions were systemic, and ranged from 0.08 to 13 percent in different countries. The incidence of adverse reactions in blood donation differ across the countries which might be related to the donors’ characteristics. The difference did even existed in studies conducted in the same country and the same year. This suggests that many factors can cause adverse reactions in blood donation, and that a wide range of them investigated in one study, most of which were systemic. Keywords: Adverse event, adverse effect, adverse reaction, complication, side effect, vasovagal reaction, local reaction, general reaction, allergic reaction, blood donor, blood donation Introduction Blood transfusion is known as a key component in every healthcare system which saves millions lives around the world each year [1]. About 30% of all people have had a need to receive blood or its products during their life [2]. Although blood donation is a very low risk procedure, the incidence of some adverse reactions is inevitable which is the most important factor in reducing the donor’s desire to donate again. This would be an obstacle against providing healthy and sufficient blood. Therefore, eliminating or reducing these factors by means of prevention, can help to achieve this goal [3]. Various adverse reactions may occur post blood donation, all of which are divided into two categories of local and systemic reactions [4]. Local reactions include hematoma, hemorrhage, bruising, and associated inflammation, while systemic reactions associated with dizziness, hyperventilation, pallor, bruising, and similar sings [5]. Although the incidence of adverse reactions in blood donation is related to many factors, the sexual distribution of donors, as well as donation type (First, Regular) and race are the most affecting factors [6-9]. In this study, a systematic review has been done on the incidence of adverse reactions in blood donation in different countries around the world and the incidence, as well as participation rate of women and first donors have been extracted. Materials and methods Search strategy To investigate adverse reactions in blood donation occurred all over the world, electronic databases, reports and documents published by various organizations was searched using keywords including “Adverse Event”, “Adverse Effect”, “Adverse Reaction”, “Complication”, “Side Effect”, “Vasovagal Reaction”, “Local Reaction”, “General Reaction”, “Allergic Reaction”, “Blood Donor” and “Blood Donation”. Different Databases such as PubMed, Web of Science, Scopus, EmBase, Ovid, as well as the specialized journal of TRAN (...truncated)