3C. 3-Ketosteroid receptors in GtoPdb v.2023.1
IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F98/2023.1
3C. 3-Ketosteroid receptors in GtoPdb v.2023.1
Derek Cain1, John Cidlowski1, Dean P. Edwards2, Peter Fuller3, Sandra L. Grimm2, Sean Hartig2, Carol A.
Lange4, Robert H. Oakley1, Jennifer K. Richer5, Carol A. Sartorius5, Marc Tetel6, Nancy Weigel2 and Morag J.
Young7
1. National Institutes of Health, USA
2. Baylor College of Medicine, USA
3. Hudson Instiitute of Medical Research, Australia
4. University of Minnesota, USA
5. University of Colorado, USA
6. Wellesley College, USA
7. Baker Heart and Diabetes Institute, Australia
Abstract
Steroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear
Hormone Receptors [75, 218, 3]) are nuclear hormone receptors of the NR3 class, with endogenous agonists
that may be divided into 3-hydroxysteroids (estrone and 17β-estradiol) and 3-ketosteroids
(dihydrotestosterone [DHT], aldosterone, cortisol, corticosterone, progesterone and testosterone). For rodent
GR and MR, the physiological ligand is corticosterone rather than cortisol.
Contents
This is a citation summary for 3C. 3-Ketosteroid receptors in the Guide to Pharmacology database (GtoPdb). It
exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database
by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which
are given here under database links.
GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a
reference work which is most usefully represented as an on-line database. As in any publication this work
should be appropriately cited, and the papers it cites should also be recognized. This document provides a
citation for the relevant parts of the database, and also provides a reference list for the research cited by
those parts. For further details see [41].
Please note that the database version for the citations given in GtoPdb are to the most recent preceding
version in which the family or its subfamilies and targets were substantially changed. The links below are to
the current version. If you need to consult the cited version, rather than the most recent version, please
contact the GtoPdb curators.
Database links
3C. 3-Ketosteroid receptors
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=98
Introduction to 3C. 3-Ketosteroid receptors
https://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=98
Receptors
Androgen receptor
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=628
Glucocorticoid receptor
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=625
Mineralocorticoid receptor
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=626
Progesterone receptor
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=627
References
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SD and Pawson AJ et al.. (2019) THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Nuclear hormone
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PR-B and PR-A, in breast cancer: correlations with clinicopathologic tumor parameters and expression
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conditional expression of an antisense mRNA of the mineralocorticoid receptor in cardiomyocytes.
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18. Bentvelsen FM, McPhaul MJ, Wil (...truncated)
