The impact of self-management support on the progression of chronic kidney disease—a prospective randomized controlled trial

Nov 2011

Background. Chronic kidney disease (CKD) is a public health problem worldwide. Multidisciplinary intervention helps improve outcomes for CKD patients. We conducted an open-label, randomized controlled trial to examine the impact of self-management support (SMS) in the outcome of late-stage CKD patients. Methods. Incidental CKD (Stages III–V) patients were randomized into self-management support (SMS) and non-SMS groups and followed up for 12 months. SMS comprised health information, patient education, telephone-based support and the aid of a support group. The primary end points were absolute estimated glomerular filtration rate (eGFR) alteration and number of hospitalization events. The secondary end points were an eGFR decrease of up to 50%, end-stage renal disease (ESRD) demanding renal replacement therapy (RRT), all-cause mortality or a composite secondary end point. Results. The study included 54 patients; 27 patients were randomized into an SMS group and the same number into a non-SMS group. The absolute eGFR at the end of the study was significantly higher in SMS patients than in the non-SMS group (29.11 ± 20.61 versus 15.72 ± 10.67 mL/min; P < 0.05). There were fewer hospitalization events for SMS patients than for non-SMS patients [5 (18.50%) versus 12 (44.47%); P < 0.05]. One patient (3.7%) in the SMS group and nine (33.3%) in the non-SMS group had an eGFR reduction of >50% (P < 0.05). However, survival analysis of the composite secondary end points of ESRD that required RRT and all-cause mortality revealed no differences between the two groups. Conclusions. Our randomized study suggests that a standardized SMS program may play a significant role in reducing CKD progression and morbidity of late-stage CKD patients.

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The impact of self-management support on the progression of chronic kidney disease—a prospective randomized controlled trial

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Kidney Int 1998; 54: 1320–1323 Received for publication: 26.7.10; Accepted in revised form: 14.6.11 Nephrol Dial Transplant (2011) 26: 3560–3566 doi: 10.1093/ndt/gfr047 Advance Access publication 17 March 2011 The impact of self-management support on the progression of chronic kidney disease—a prospective randomized controlled trial Sue-Hsien Chen1,2, Yun-Fang Tsai1,2, Chiao-Yin Sun3,4, I-Wen Wu3,4, Chin-Chan Lee3,4 and Mai-Szu Wu3,4 1 Department of Nursing, Chang Gung Memorial Hospital, Keelung, Taiwan; Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan, 2Chang Gung University, Taoyuan, Taiwan, School of Nursing, Taoyuan, Taiwan, 3Division of Nephrology, Chang Gung Memorial Hospital at Keelung, Taoyuan, Taiwan and 4Chang Gung University, Taoyuan, Taiwan, School of Medicine, Taoyuan, Taiwan Correspondence and offprint requests to: Mai-Szu Wu; E-mail: Abstract Background. Chronic kidney disease (CKD) is a public health problem worldwide. Multidisciplinary intervention helps improve outcomes for CKD patients. We conducted an open-label, randomized controlled trial to examine the impact of self-management support (SMS) in the outcome of late-stage CKD patients. Methods. Incidental CKD (Stages III–V) patients were randomized into self-management support (SMS) and non-SMS groups and followed up for 12 months. SMS comprised health information, patient education, telephone-based support and the aid of a support group. The primary end points were absolute estimated glomerular filtration rate (eGFR) alteration and number of hospitalization  The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: Europe and Australia/New Zealand: results from an international comparative study. Am J Kidney Dis 2000; 35: 157–165 3. Noel LH, Zanetti M, Droz D et al. Long-term prognosis of idiopathic membranous glomerulonephritis. Study of 116 untreated patients. 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Clinical and morphological prognostic factors in membranous nephropathy: significance of focal segmental glomerulosclerosis. Am J Kidney Dis 2003; 41: 38–48 10. Wakai S, Magil AB. Focal glomerulosclerosis in idiopathic membranous glomerulonephritis. Kidney Int 1992; 41: 428–434 11. Wehrmann M, Bohle A, Bogenschütz O et al. Long-term prognosis of chronic idiopathic membranous glomerulonephritis. An analysis of 334 cases with particular regard to tubulo-interstitial changes. Clin Nephrol 1989; 31: 67–76 12. Wu Q, Jinde K, Nishina M et al. Analysis of prognostic predictors in idiopathic membranous nephropathy. Am J Kidney Dis 2001; 37: 380–387 13. Troyanov S, Roasio L, Pandes M et al. Renal pathology in idiopathic membranous nephropathy: a new perspective. Kidney Int 2006; 69: 1641–1648 N. Tsuboi et al. Impact of self-management support on progression of CKD Keywords: chronic kidney diseases; end-stage renal disease; self-management; self-management support Introduction share responsibility for treatment decisions with patients [12, 13]. Active patient participation is paramount in the effective management of CKD, which is a long-lasting, frustrating and often progressive disease. Progression may be partly delayed with self-management [14]. However, the long-lasting nature of the disease, along with its progression, makes CKD self-management difficult. Furthermore, self-management is not easy to evaluate, especially in the long-term. The specific nature of CKD self-management highlights the importance of self-management support (SMS) for this progressive disease. SMS refers to those facilities that health care services provide to enable patients to manage their health better. It includes the provision of health information, patient education, telephone-based support and the aid of a support group [15]. Little is known about the impact of standardized SMS programs on disease progression and morbidity in CKD patients. To evaluate the influence of SMS in CKD care, we conducted an open-label, randomized controlled trial of late-stage CKD (Stages III–V) patients. The aim of the study was to investigate the effect of SMS on CKD progression. The results could be important in establishing the role of SMS in the daily care of CKD patients. Materi (...truncated)


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Sue-Hsien Chen, Yun-Fang Tsai, Chiao-Yin Sun, I-Wen Wu, Chin-Chan Lee, Mai-Szu Wu. The impact of self-management support on the progression of chronic kidney disease—a prospective randomized controlled trial, 2011, pp. 3560-3566, 26/11, DOI: 10.1093/ndt/gfr047