A great honor and a huge challenge for China: You-you TU getting the Nobel Prize in Physiology or Medicine

Yuan et al. / J Zhejiang Univ-Sci B (Biomed & Biotechnol) 2016 17(5):405-408 405 Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) ISSN 1673-1581 (Print); ISSN 1862-1783 (Online) www.zju.edu.cn/jzus; www.springerlink.com E-mail: Correspondence: A great honor and a huge challenge for China: You-you TU getting the Nobel Prize in Physiology or Medicine Da YUAN1, Xue YANG2, Jun-chao GUO†‡1 (1Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China) (2Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China) † E-mail: http://dx.doi.org/10.1631/jzus.B1600094 Public excitement over the award of the 2015 Nobel Prize in Physiology or Medicine to the Chinese medical scientist You-you TU for the discovery of a herbal anti-malarial, may mislead the Chinese people into believing that traditional Chinese herbal medicine can be used to cure all disease without any adverse effects. The aim of this paper is to explain the advantages and disadvantages of herbal traditional Chinese medicine (TCM) objectively. 1 Introduction It is a great honor that the Chinese medical scientist You-you TU won the Nobel Prize in Physiology or Medicine 2015 for discovering artemisinin, which has saved hundreds of thousands of patients with malaria all over the world. According to the WHO World Malaria Report 2014 (World Health Organization, 2014), “the mortality rate from malaria will decrease by 55% worldwide and 62% in the WHO African Region by 2013, if the annual rate of decrease over the past 13 years is maintained.” In children under ‡ Corresponding author ORCID: Da YUAN, http://orcid.org/0000-0003-0364-8788 © Zhejiang University and Springer-Verlag Berlin Heidelberg 2016 five years of age, the positive result is even more dramatic with a 61% decrease in mortality rate expected worldwide and a 67% decrease expected in the WHO African Region. According to the Nobelprize. org. Nobel Media AB (2015), more than ten thousand people have been saved each year and in Africa alone, artemisinin-derived drugs have been used by nearly 250 million patients. Since 2006, artemisinin-based combination therapies (ACTs) have been recommended by the WHO as the priority treatment for malaria and have been adopted as first-line treatments in 79 of 88 countries where Plasmodium falciparum is endemic (World Health Organization, 2015). Thus, the discovery of artemisinin is really a huge contribution to the world. However, the details of its discovery were fraught (Kong and Tan, 2015). 2 Main points When news of the Nobel Prize spread to China, it provoked a sensation among Chinese scientists and the public. After all, it is the first time that a civilian from the People’s Republic of China has won the prize since the founding of New China and the media have reported on this news almost every day since. Chinese citizens, being proud of this achievement, have started to consider that herbal TCM is really useful and may cure all diseases. There is no question that TCM is effective in treating some diseases, but the assumption that it can cure all diseases is dangerous and will harm the credibility of TCM as part of the Chinese health system. In the past, many Chinese became sick after consuming herbal TCM at unsafe doses or when treated inappropriately: previous cases related to aristolochic acid-induced nephropathy; more recently 406 Yuan et al. / J Zhejiang Univ-Sci B (Biomed & Biotechnol) 2016 17(5):405-408 herbal hepatitis has come into focus. Another problem occurs when patients of some informal clinics are prescribed by doctors who do not even have a TCM license, leading to improper diagnosis and treatment. Generally speaking, Chinese medicine is a gift to the world, but its disadvantages as well as its advantages must be considered. TCM can cure diseases for which effective western treatment is not available, for example kidney disease (Zhong et al., 2015), but if not used properly, it can lead to serious health problems. Wang et al. (2009) have discussed in detail aspects of the efficacy, safety, and quality of herbal TCM, but more evidence-based clinical trials are required to evaluate the benefit:risk ratio of herbal TCM (Teschke and Eickhoff, 2015). The China Food and Drug Administration (CFDA) has made progress in pharmacovigilance and risk control, taking into account the toxicology of Chinese herbal products (Shaw, 2010; Zhang et al., 2012). The intention of this paper is to make recommendations to Chinese consumers and the Chinese government by taking Chinese a look at some common adverse reactions associated with the use of herbal TCM. Several herbs have been reported to have hepatic, renal, and gastrointestinal toxicities, but this is just the tip of the iceberg (Shaw, 2010; Teschke et al., 2014; Nyirimigabo et al., 2015). According to research from 1949 to 2006 provided by Li (2007), among 12 354 cases describing side effects, 153 deaths were associated with the use of 158 different types of herbs. Many other cases, or even deaths, probably went unreported. 2.1 Hepatotoxicity Herb-induced liver injury (HILI) is one of the most common adverse effects caused by TCM. This has been reported in many countries around the world, including China (Taiwan region and the mainland), Japan, and Korea (US National Library of Medicine, 2014). According to Teschke et al. (2014), altogether 18 classifiable herbal mixtures and 39 individual herbs that are used to cure flu and colds have been reported to cause potential hepatotoxicity. The liver damage usually presents with symptoms such as fatigue, nausea, vomiting, and dark urine. If no effective actions are taken, the clinical outcome can be severe and even leads to acute liver failure with risk of death or the requirement for a liver transplant. Some of the toxicities associated with herbal TCM are well under- stood or documented: Wang et al. (2015) have described an experiment that proved kudzu root extractinduced hepatotoxicity; an experiment in rats showed that yuanhuapine-induced intestinal and hepatic toxicities were correlated with disturbance of amino acid metabolism, lipid metabolism, carbohydrate metabolism, and gut microflora (Chen et al., 2015); and, from 1992 to 2015, 693 cases have been reported for Chinese herbal hepatotoxicity (Teschke et al., 2015). Hepatotoxicity by herbal TCM must be validly established using a causality assessment method that is specific for the liver and hepatotoxicity such as Roussel Uclaf Causality Assessment Method (RUCAM) (Danan and Teschke, 2016). 2.2 Nephrotoxicity Physicians from the US published the first case of kidney failure relating to traditional Chinese herb use in 1993 (Izumotani et al., 1993). Subsequently, aristolochic acid nephropathy was reported in Belgium in 2008 (Debelle et al., 2008). Nephrotoxi (...truncated)