Cardiorespiratory fitness: a comparison between children with renal transplantation and children with congenital solitary functioning kidney

Lubrano et al. Italian Journal of Pediatrics (2016) 42:90 DOI 10.1186/s13052-016-0299-7 LETTER TO THE EDITOR Open Access Cardiorespiratory fitness: a comparison between children with renal transplantation and children with congenital solitary functioning kidney Riccardo Lubrano1,4* , Giancarlo Tancredi1, Raffaele Falsaperla2 and Marco Elli3 Abstract Children with end-stage renal disease are known to have a cardiorespiratory fitness significantly reduced. This is considered to be an independent index predictive of mortality mainly due to cardiovascular accidents. The effects of renal transplantation on cardiorespiratory fitness are incompletely known. We compared the maximal oxygen uptake (VO2 max) of children with a functioning renal transplant with that of children with congenital solitary functioning kidney, taking into consideration also the amount of weekly sport activity. Keywords: VO2 max, Cardiorespiratory fitness, Chronic renal failure, Child, Physical activity, Renal transplant, Solitary functioning kidney Dear Editor, Patients with chronic renal failure (CRF) tend to reduce their weekly amount of physical activity, with negative effects on cardiorespiratory fitness and quality of life. After renal transplant the metabolic deficits induced by CRF are partially recovered and cardiorespiratory fitness improves. As we previously reported cardiorespiratory fitness of transplanted children practicing sports for more than 3 h per week is similar to normal controls exercising less that 3 h [1]. On the contrary, cardiorespiratory fitness of children with a congenital solitary functioning kidney is similar to normal controls exercising for a comparable number of hours [2]. We measured the aerobic capacity in relation with weekly amount of physical activity and glomerular filtration rate (GFR), comparing a group of children with a congenital solitary functioning kidney (cSFK) and a group of children with a functioning renal transplant (Tx). * Correspondence: 1 Pediatric Department, Pediatric Nephrology Unit, Sapienza University of Rome, Rome, Italy 4 Servizio di Nefrologia Pediatrica, Dipartimento di Pediatria, Sapienza Università di Roma, Viale Regina Elena 324, 00161 Roma, Italia Full list of author information is available at the end of the article A standardized pediatric questionnaire was administered to all children for investigating the time dedicated weekly to physical activity [3]. On the basis of the questionnaire, the children were divided into inadequately active (<3 h of physical activity per week) and adequately active (>3 h of physical activity per week). In the cSFK group we enrolled 30 patients: 15 exercising more than 3 h/week (cSFK>3) and 15 less than 3 h/ week (cSFK<3). The Tx group was formed with 20 children, 10 exercising more than 3 h/week (Tx>3) and 10 less than 3 h/week (Tx<3). In all patients, transplant had been performed 6 or more years previously, following a dialysis treatment never exceeding on year. All received triple immunosuppressive therapy: 12 with tacrolimus and 8 with cyclosporine. Maximal oxygen uptake (VO2 max) was measured during a maximal incremental exercise on a treadmill (Bruce protocol) consisting of sequential increase in speed and slope every 3 min until exhaustion (breathlessness and leg muscle pain) and/or heart rate ≥85 % of maximum (calculated with the formula 220 – age in years). During the exercise the subjects were connected by face mask to a breath-by-breath analyser of O2 to measure the oxygen consumption (VO2). Maximal oxygen uptake (VO2 max) was defined as the © 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Lubrano et al. Italian Journal of Pediatrics (2016) 42:90 Page 2 of 2 Table 1 VO2 max/kg in the four groups of the study Tx>3 VO2 max/kg ml/ min/kg Tx<3 cSFK>3 cSFK<3 28.99 ± 1.15 23.22 ± 1.23 46.12 ± 1.09 38.55 ± 1.97 Tx>3 vs Tx<3 p < 0.003; cSFK>3 vs cSFK<3 p < 0.01; Tx>3 vs cSFK>3 p < 0.016; Tx<3 vs cSFK<3 p < 0.001; Tx<3 vs cSFK>3 p < 0.004; Tx>3 vs cSFK<3 p < 0.001 highest level of VO2 reached during the maximal exercise test expressed as VO2 max/kg (ml/min/kg). The glomerular filtration rate (ml/min/1.73mq) was calculated with the creatinine clearance. Informed consent was obtained from both parents. The protocol conforms to the guidelines of the Declaration of Helsinki and was approved by the ethical committee of the involved institution. The children in all groups were comparable for age (years: Tx>3 12.67 ± 3.56; Tx<3 13.90 ± 1.20; cSFK>3 14.18 ± 5.29; cSFK<3 13,5 ± 4.76; p NS). GFR was also similar in all groups (GFR ml/min/1.73 mq: Tx>3 90.65 ± 22.52; Tx<3 92.02 ± 21.18; cSFK>3 99.15 ± 30.63; cSFK<3 101,02 ± 40.12; p NS). VO2 max in Tx and cSFK was significantly higher in those practicing sport for more than 3 h per week (Table 1). Children with a congenital solitary functioning kidney had level of VO2 max consistently and significantly higher than transplanted patients (Table 1). There was no significant correlation between VO2 max and GFR (VO2 max = 26.08 + 0.006; GFR R^2 = − 0.07). Our findings show that not only congenital solitary functioning kidney (cSFK), but also transplanted children with regular physical activity exceeding three hours weekly achieve higher levels of VO2 max. Adequate and regular physical exercise proves therefore beneficial in transplanted children improving their ability to cope with the increased metabolic request of physical stress and therefore reducing the risk of mortality from cardiovascular disease [4]. VO2 max in transplanted children is consistently lower than single kidney patients with comparable physical activity. This may be due in part to the neuromuscular, metabolic, and cardiopulmonary deficits acquired during the exposure to uremic intoxication before transplant [5], that a functioning graft can improve but not reverse completely. A combination of early transplant and prompt resumption of controlled adequate physical exercise post-transplant is likely to improve further the cardiorespiratory fitness in these patients, with the known benefits on cardiovascular risk and mortality. Abbreviations 3 h/week: 3 hours a week; CRF: Chronic renal failure; cSFK: Congenital solitary functioning kidney; GFR: Glomerular filtration rate; Tx: Transplanted children; VO2 max: Maximal oxygen uptake Funding Nothing to declare. Authors’ contributions RL participated in the design of the study, performed (...truncated)