Ion channel messenger RNA processing defects and arrhythmia Anyu Zhou, Samuel C Dudley Jr Lifespan Cardiovascular Research Center, The Warren Alpert School of Medicine, Brown University, and Providence Veterans Administration Medical Center, Providence, RI, USA Abstract: Messenger RNA (mRNA) processing is an essential step for the expression of most eukaryote genes. Ion channels...
Polyclonal free light chains: promising new biomarkers in inflammatory disease Judith A Hampson,1 Alice M Turner,1 Robert A Stockley2 1Department of Clinical and Experimental Medicine, University of Birmingham, 2ADAPT (Antitrypsin Deficiency Assessment and Programme for Treatment), Lung Function and Sleep Department, Queen Elizabeth Hospital, Birmingham, UK Abstract: In this...
Polyclonal free light chains: promising new biomarkers in inflammatory disease Judith A Hampson,1 Alice M Turner,1 Robert A Stockley2 1Department of Clinical and Experimental Medicine, University of Birmingham, 2ADAPT (Antitrypsin Deficiency Assessment and Programme for Treatment), Lung Function and Sleep Department, Queen Elizabeth Hospital, Birmingham, UK Abstract: In this...
Novel tumor markers in the serum of testicular germ cell cancer patients: a review Isabella Syring, Stefan C Müller, Jörg Ellinger Department for Urology and Pediatric Urology, University Hospital Bonn, Bonn, Germany Abstract: Serum tumor markers have an important role in the management of patients with testicular cancer. They are useful for diagnosis, staging and risk assessment...
Novel tumor markers in the serum of testicular germ cell cancer patients: a review Isabella Syring, Stefan C Müller, Jörg Ellinger Department for Urology and Pediatric Urology, University Hospital Bonn, Bonn, Germany Abstract: Serum tumor markers have an important role in the management of patients with testicular cancer. They are useful for diagnosis, staging and risk assessment...
Incorporating biomarkers into clinical trials in cardiovascular medicine Hsiu-Fang Lee, Sho Ota Trialynx, Inc., Ann Arbor, MI, USA Abstract: Developing novel therapies and establishing clinical benefits over conventional therapies has become a highly competitive and a costly endeavor. In this regard, biomarkers have become increasingly important in accurately assessing both...
Incorporating biomarkers into clinical trials in cardiovascular medicine Hsiu-Fang Lee, Sho Ota Trialynx, Inc., Ann Arbor, MI, USA Abstract: Developing novel therapies and establishing clinical benefits over conventional therapies has become a highly competitive and a costly endeavor. In this regard, biomarkers have become increasingly important in accurately assessing both...
Current studies of biomarkers for the early diagnosis of rheumatoid arthritis S Chandrashekara ChanRe Rheumatology and Immunology Center and Research, Basaveshwaranagar, Bangalore, India Abstract: Early treatment of rheumatoid arthritis (RA) with disease-modifying antirheumatic drugs will improve the outcome significantly. Early diagnosis of RA continues to be a challenge. The...
Current studies of biomarkers for the early diagnosis of rheumatoid arthritis S Chandrashekara ChanRe Rheumatology and Immunology Center and Research, Basaveshwaranagar, Bangalore, India Abstract: Early treatment of rheumatoid arthritis (RA) with disease-modifying antirheumatic drugs will improve the outcome significantly. Early diagnosis of RA continues to be a challenge. The...
Biomarkers in sarcoidosis: a review Hasib Ahmadzai,1,2 Wei Sheng Joshua Loke,1 Shuying Huang,1 Cristan Herbert,1 Denis Wakefield,3 Paul S Thomas2 1Inflammation and Infection Research Centre (IIRC), Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia; 2Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, Sydney, NSW, Australia; 3Immunology...
Biomarkers in sarcoidosis: a review Hasib Ahmadzai,1,2 Wei Sheng Joshua Loke,1 Shuying Huang,1 Cristan Herbert,1 Denis Wakefield,3 Paul S Thomas2 1Inflammation and Infection Research Centre (IIRC), Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia; 2Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, Sydney, NSW, Australia; 3Immunology...
Biomarkers in the Ewing sarcoma family of tumors Isidro Machado,1 José Antonio López-Guerrero,2 Antonio Llombart-Bosch31Pathology Department, Instituto Valenciano de Oncología, Valencia, Spain; 2Molecular Biology Department, Instituto Valenciano de Oncología, Valencia, Spain; 3Pathology Department, University of Valencia, Valencia, Spain Abstract: This review provides a concise...
Biomarkers in the Ewing sarcoma family of tumors Isidro Machado,1 José Antonio López-Guerrero,2 Antonio Llombart-Bosch31Pathology Department, Instituto Valenciano de Oncología, Valencia, Spain; 2Molecular Biology Department, Instituto Valenciano de Oncología, Valencia, Spain; 3Pathology Department, University of Valencia, Valencia, Spain Abstract: This review provides a concise...
Electrophysiological biomarkers for improved etiological diagnosis of cognitive impairment Takao Yamasaki,1,2 Shozo Tobimatsu1 1Department of Clinical Neurophysiology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; 2Department of Neurology, Minkodo Minohara Hospital, Fukuoka, Japan Abstract: Alzheimer's disease (AD), Lewy body...
Electrophysiological biomarkers for improved etiological diagnosis of cognitive impairment Takao Yamasaki,1,2 Shozo Tobimatsu1 1Department of Clinical Neurophysiology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; 2Department of Neurology, Minkodo Minohara Hospital, Fukuoka, Japan Abstract: Alzheimer's disease (AD), Lewy body...
Predicting cetuximab efficacy in patients with advanced colorectal cancer Ibrahim H Sahin, Christopher R Garrett Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA Abstract: Cetuximab has demonstrated activity, both as monotherapy, and in combination with cytotoxic chemotherapy, albeit modest. Efforts over the last...
Predicting cetuximab efficacy in patients with advanced colorectal cancer Ibrahim H Sahin, Christopher R Garrett Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA Abstract: Cetuximab has demonstrated activity, both as monotherapy, and in combination with cytotoxic chemotherapy, albeit modest. Efforts over the last...
Biomarkers of cardiac function and outcome in univentricular congenital heart disease Harold S Bernstein,1,2 Hythem Nawaytou3 1Merck Sharp & Dohme Corp, Whitehouse Station, NJ, USA; 2The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; 3Department of Pediatrics, University of California, San Francisco, CA, USA Abstract: A...
Biomarkers of cardiac function and outcome in univentricular congenital heart disease Harold S Bernstein,1,2 Hythem Nawaytou3 1Merck Sharp & Dohme Corp, Whitehouse Station, NJ, USA; 2The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; 3Department of Pediatrics, University of California, San Francisco, CA, USA Abstract: A...
Predicting efficacy of sunitinib in metastatic renal cell carcinoma Carlo Ganini,1,* Camillo Porta1,2,* 1Medical Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Matteo University Hospital Foundation, 2Italian Group of Nephro-Oncology/Gruppo Italiano di Oncologia Nefrologica, Pavia, Italy *Both authors contributed equally to this paper Abstract: Renal...
Predicting efficacy of sunitinib in metastatic renal cell carcinoma Carlo Ganini,1,* Camillo Porta1,2,* 1Medical Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Matteo University Hospital Foundation, 2Italian Group of Nephro-Oncology/Gruppo Italiano di Oncologia Nefrologica, Pavia, Italy *Both authors contributed equally to this paper Abstract: Renal...
Biomarkers in fibromyalgia: a review Camillo Giacomelli,* Francesca Sernissi,* Alessandra Rossi, Stefano Bombardieri, Laura BazzichiRheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy *These authors contributed equally to the manuscript Abstract: Fibromyalgia is a common syndrome diagnosed by clinical criteria. The main symptom of...
Biomarkers in fibromyalgia: a review Camillo Giacomelli,* Francesca Sernissi,* Alessandra Rossi, Stefano Bombardieri, Laura BazzichiRheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy *These authors contributed equally to the manuscript Abstract: Fibromyalgia is a common syndrome diagnosed by clinical criteria. The main symptom of...
Arterial stiffness as a noninvasive tissue biomarker of cardiac target organ damage Nicole L Spartano,1 Jacqueline A Augustine,1 Wesley K Lefferts,1 William E Hughes,1 Jessica Garay Redmond,1 Eileen D Martin,1 Jeffrey T Kuvin,2 Brooks B Gump,3 Kevin S Heffernan11Department of Exercise Science, Syracuse University, Syracuse, NY, USA; 2Division of Cardiology, Tufts Medical Center...
Arterial stiffness as a noninvasive tissue biomarker of cardiac target organ damage Nicole L Spartano,1 Jacqueline A Augustine,1 Wesley K Lefferts,1 William E Hughes,1 Jessica Garay Redmond,1 Eileen D Martin,1 Jeffrey T Kuvin,2 Brooks B Gump,3 Kevin S Heffernan11Department of Exercise Science, Syracuse University, Syracuse, NY, USA; 2Division of Cardiology, Tufts Medical Center...