Journal of Medical Case Reports

<p><em>Journal of Medical Case Reports</em> will consider any original case report that expands the field of general medical knowledge, and original research relating to case reports.</p> <p>Case reports should show one of the following:</p> Unreported or unusual side effects or adverse interactions involving medications Unexpected or unusual presentations of a disease New associations or variations in disease processes Presentations, diagnoses and/or management of new and emerging diseases An unexpected association between diseases or symptoms An unexpected event in the course of observing or treating a patient Findings that shed new light on the possible pathogenesis of a disease or an adverse effect <p></p> <p>Suitable research articles include but are not limited to: N of 1 trials, meta-analyses of published case reports, research addressing the use of case reports and the prevalence or importance of case reporting in the medical literature and retrospective studies that include case-specific information (age, sex and ethnicity) for all patients.</p>

List of Papers (Total 11,396)

Ivermectin treatment for nasal myiasis complicated by orbital cellulitis: a case report

Nasal myiasis is a rare parasitic infestation caused by fly larvae, which can lead to serious complications, such as orbital cellulitis, if not treated promptly. Early recognition and intervention are essential to prevent further complications. We present a case of a 55-year-old Thai female with advanced-stage malignant melanoma of the right nasal cavity, treated with endoscopic...

Effect of combined aerobic and resistance training with self-selected intensity on clinical parameters and fitness in a patient with mixed anxiety and depressive disorder: a case report

This case study assessed the effects of a combined aerobic and resistance training intervention with self-selected exercise intensity in a patient with mixed anxiety and depressive disorder. A 24-year-old Brazilian female patient (1.57 m, 62.6 kg), sedentary, with a clinical diagnosis of mixed anxiety and depressive disorder (F41.2 according to ICD-10) for 9 months participated...

Esophageal obstruction by mediastinal seroma after laparoscopic repair of a giant hiatal hernia: a case report

Hiatal hernia is increasingly prevalent in the Western population. Its incidence increases with age and morbid obesity and is higher in females. Symptomatic hiatal hernias, particularly grade IV, are associated with significant morbidity and severe symptoms, and often necessitate acute surgical intervention. We present a case of a 64-year-old Caucasian female patient with acute...

Takotsubo cardiomyopathy with rapid left ventricular recovery unmasking asymptomatic but significant coronary artery disease: a case report

Takotsubo cardiomyopathy, also known as stress-induced cardiomyopathy, is a transient cardiac condition characterized by acute but reversible left ventricular dysfunction, typically triggered by emotional or physical stress. While Takotsubo cardiomyopathy usually occurs in the absence of significant coronary artery disease, its coexistence with severe coronary artery disease is...

Introducing a novel technique for auricular replantation following subtotal amputation combining Sexton and Mladick pocket methods: a case report

Traumatic auricular amputations present a unique surgical challenge, particularly in cases where microsurgical anastomosis is not feasible due to vessel damage or absence. Traditional reconstruction techniques often yield suboptimal aesthetic or functional results. The pocket technique, as described by Sexton and Mladick, has shown promise in such scenarios, particularly in...

A presentation of recurrent cerebral ischemic stroke in eosinophilic granulomatosis with polyangiitis: a case report

Eosinophilic granulomatosis with polyangiitis is characterized as a small vessel vasculitis with the propensity to have a myriad of presentations due to the targeting of several different organ systems. More often than not, it is the pulmonary system that is affected. However, other reported presentations have included involvement of the skin, cardiovascular system, neurological...

The first Mpox case in Zambia: a case report

Mpox, a viral infection caused by an Orthopoxvirus, has reemerged outside its historically endemic regions in Central and West Africa. This geographical expansion introduces a potential risk of transmission in Zambia, where geographic proximity and active trade routes increase vulnerability. We report the first confirmed case of Mpox in Zambia, involving a 32-year-old Tanzanian...

Fatal tricuspid valve inflow obstruction and inferior vena cava syndrome in a child with advanced Wilms’ tumor: a case report

Wilms’ tumor is the most common primary renal malignancy in children. Although tumor extension into the inferior vena cava occurs in 4–10% of cases, intracardiac involvement is rare, reported in only 1%. In resource-limited settings, delayed diagnosis and inadequate access to specialized care may lead to fatal complications. We report the case of an 8-year-old Tanzanian girl...

Acute ischemic stroke in a young adult in association with Epstein–Barr virus infection: a case report

Ischemic strokes are a leading cause of disability. While traditional risk factors including hypertension and diabetes are common, younger adults may experience strokes from less typical causes, such as infections. This case report presents an acute ischemic stroke in a young adult linked to Epstein–Barr virus infection, emphasizing the potential role of viral infections in...

Acute subumbilical appendicitis in a patient undiagnosed with intestinal malrotation: a case report

Acute appendicitis in the presence of intestinal malrotation is an uncommon and distinctive clinical condition. Herein, we present a rare case of subumbilical appendicitis resulting from previously undiagnosed intestinal malrotation. A 16-year-old Saudi Arab man with no known chronic illness presented with acute suprapubic abdominal pain accompanied by nausea and vomiting. The...

Visual rehabilitation of a fighter pilot by utilizing a combination of contact lenses: a case report

Penetrating keratoplasty is often necessary when corneal scars impact the visual axis. Post-surgical irregular astigmatism resulting from corneal deformity may necessitate the use of rigid gas permeable or scleral contact lenses to enhance visual quality. However, lens fitting becomes challenging when irregularity involves the peripheral cornea. Pinhole contact lenses are used to...

Metastasizing ameloblastoma: a case report

Metastasizing ameloblastoma is a rare, distinct entity under the World Health Organization classification. It is a unique tumor in which metastasis can occur but remains benign. Incidence is considered to be around 2% of reported cases of ameloblastoma, but it could be much lower. A 30-year-old South Indian woman of Dravidian ethnicity presented in the year 2020 with swelling...

Cardiac tamponade as an initial atypical presentation of T-cell lymphoblastic lymphoma in a 17-year-old adolescent: a case report

T-cell lymphoblastic lymphoma is a type of non-Hodgkin’s lymphoma, which usually affects adolescents and young adults. The usual presentation is characterized by B symptoms and adenopathy associated with a mediastinal mass. Here we describe a rare case of T-cell lymphoblastic lymphoma in an adolescent, presenting as cardiac tamponade. The patient is a 17-year-old Moroccan...

Heavy proteinuria of 25.4 g per 24 hours in a 52-year-old patient from Ethiopia with steroid-responsive minimal change disease: a case report

Nephrotic syndrome refers to a distinct constellation of clinical and laboratory features of renal disease. The majority of cases of glomerular proteinuria range from 1 to 15 g of protein per 24 hours of urine. Heavy proteinuria of 25.4 g with steroid-responsive nephrotic syndrome is a rare clinical presentation of glomerulopathy. This patient presented with a significantly high...

Malignant paraganglioma of the vagus nerve: diagnostic and therapeutic strategies—a case report

Vagal paragangliomas are rare neuroendocrine tumors of the parapharyngeal space, with a small subset exhibiting malignant behavior. Their diagnosis and management remain challenging owing to anatomical complexity and risk of cranial nerve morbidity. We report a 46-year-old Maghrebine woman presenting with severe dysphagia and a right lateral cervical mass. Imaging revealed a 40.2...

Early nail involvement in mycosis fungoides with rapid systemic progression: rethinking the role of Ki-67: a case report

Mycosis fungoides, the most common cutaneous T-cell lymphoma, typically exhibits a gradual progression. However, aggressive forms with extracutaneous involvement and low proliferative indices may present diagnostic and prognostic challenges. Nail involvement appears to be infrequent and poorly understood, and is often considered a late-stage manifestation. The Ki-67 index...

Cylindroma of the neck in a male patient: a case report

Cylindroma is a benign adnexal tumor mostly found on the scalp or face. They present as pink to purple, smooth-surfaced, solitary or multiple nodular lesions, mostly affecting middle-aged and elderly women. Reports of solitary cylindromas occurring in other anatomical locations are rare. We present a unique case of a 56-year-old Arab male patient with a solitary, large, non...

Anterior Stafne bone cavity in mandibular canine-premolar region: a case report

Stafne bone cavity is a rare, asymptomatic, nonprogressive, developmental pseudocyst typically found incidentally in the posterior mandible. Its occurrence in the anterior mandibular region, especially in the canine-premolar area, is extremely rare and often misdiagnosed as periapical pathology due to its radiographic appearance. This case is unique as it highlights an anterior...

Mevalonate kinase deficiency (hyperimmunoglobulin D syndrome) in a Tanzanian girl: a case report

Hyperimmunoglobulin D syndrome is a rare autosomal recessive autoinflammatory syndrome caused by mevalonate kinase enzyme deficiency. It is characterized by recurrent febrile attacks beginning in the first year of life. Treatment is mainly supportive, and there are successful reports of trials of novel therapies such as anakinra and canakinumab. We present a case of a 3-month-old...

Hypopharyngeal squamous cell carcinoma in a patient with germline TP53 c.743G > A (p.Arg248Gln) variant: a case report

Hypopharyngeal squamous cell carcinoma is a rare and aggressive malignancy of the upper aerodigestive tract. While tobacco and alcohol remain the primary etiologic factors, hereditary cancer predisposition syndromes—particularly those involving germline TP53 mutations—can contribute to early onset disease. We report a case of a 45-year-old Iranian male patient with moderately...

A frontier in oncology: managing stage IVB primary ovarian leiomyosarcoma with gallbladder metastasis: a case report and review of literature

Primary ovarian leiomyosarcoma is an exceedingly rare and aggressive tumor, accounting for less than 0.1% of ovarian malignancies. Owing to its nonspecific clinical presentation, primary ovarian leiomyosarcoma is often diagnosed at an advanced stage. To date, metastatic spread to the gallbladder has not been documented. We present the first reported case of gallbladder metastasis...

Polycythemia secondary to renal dromedary hump in a young healthy woman: a case report

Renal dromedary hump is a benign anatomic variant with same echogenicity and blood flow as normal renal parenchyma in imaging modalities. In the present study, we report secondary erythrosytosis due to renal dromedary hump in a young healthy woman. A 32-year-old, previously healthy Persian woman referred to our clinic with a 2-month history of bruises. On investigations, patient...

Importance of early prehospital intervention in crush injury and compartment syndrome: a case report

Crush injuries are commonly associated with natural disasters or human-made mass casualty events, affecting millions annually. Reports on non-disaster-related cases are limited. We present the case of a non-disaster-induced crush injury in which a Chinese patient’s arm was trapped in a toilet drain for 15 hours. Emergency medical services and a hospital medical team were...

Bilateral primary nonrefluxing unobstructed megaureter in an adult: a case report and review of the literature

Bilateral primary nonrefluxing unobstructed megaureter is a rare condition in adults, often identified during evaluation for nonspecific symptoms. Primary nonrefluxing unobstructed megaureter is more commonly diagnosed in pediatric populations, typically through antenatal imaging. A 43-year-old South Asian male presented with persistent dull left loin pain lasting 2 weeks. His...

Partial ischemic necrosis of the uterus following artery ligation for postpartum hemorrhage after placental abruption: a case report

Uterine necrosis is a rare condition that most commonly occurs during the postpartum period as a severe side effect of conservative interventions for postpartum hemorrhage. The primary treatment for uterine necrosis is a hysterectomy, and conservative management is rarely reported. We present the case of a 30-year-old Chinese woman, unipara, who underwent an emergency cesarean...