Objectives: Genetic variations contribute significantly to inter-individual responses to drugs and side effects. Pharmacogenomics has the potential to be utilized as a tool in disorders like schizophrenia with a high degree of genetic inheritance, although ...
Wound infection remains a major challenge for health professionals, because it delays wound healing and increases the overall cost and morbidity. Therefore, the development of new biomaterials with new antibacterial properties and healing effects remains ...
Objective: To compare the safety profiles between propofol and sevoflurane in pediatric anesthesia and to investigate risk factors for postoperative adverse reactions. Methods: The data of 194 children who received surgical treatment in Peking Union Medical ...
Purpose: Hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) is associated with a poor prognosis for HCC patients. Herein we aimed to establish a scoring system to predict the risk of PVTT formation in hepatitis B virus (HBV)-associated ...
Objective: Heart failure with preserved ejection fraction (HFpEF) is a complex cardiovascular syndrome. Along with pro-inflammatory and metabolic factors, epicardial adipose tissue (EAT) is believed to play a key role in the pathogenesis of HFpEF. Studies ...
Background: Intervertebral disc degeneration (IVDD) often leads to low back pain, which severely affects people’s quality of life. Oxidative stress (OS) can accelerate nucleus pulposus cell (NPCs) senescence and apoptosis. Exploring the mechanism ...
Objective: To investigate the anti-cerebral ischemia-reperfusion injury (CIRI) effect and mechanism of Zhenlong Xingnao capsules based on Notch/NF-κB signaling pathway. Methods: The rat model of middle cerebral artery occlusion (MCAO) was established ...
Objectives: Animal models are needed to reliably separate the effects of mechanical joint instability and inflammation on posttraumatic osteoarthritis (PTOA) pathogenesis. We hypothesized that our modified intra-articular drilling (mIAD) procedure induces ...
Objectives: The conversion of protein arginine residues to citrulline by calcium-dependent peptidyl arginine deiminases (PADs) has been implicated in the pathogenesis of several diseases, indicating that PADs are therapeutic targets. A recent study indicated ...
Objective: To analyze the predictive effect of a back propagation (BP) neural network, random forest (RF) and decision tree model on the prognosis of elderly patients with cardiogenic shock after extracorporeal membrane oxygenation (ECMO). Methods: This ...
Objectives: Genomic instability in cancer cells is based on the aberrant activation of deoxyribonucleic acid (DNA) damage response and repair mechanisms. Targeting Ataxia telangiectasia and Rad3-related (ATR) inhibition in cancer treatment have attracted ...
Objective: To investigate the effect of Snyder’s hope theory in emergency care for patients with acute myocardial infarction (AMI). Methods: This retrospective study included 200 AMI patients admitted to Rugao People’s Hospital from January ...
Objectives: The regulation of various cellular functions such as growth, proliferation, metabolism, and angiogenesis, is dependent on the PI3K pathway. Recent evidence has indicated that kidney renal clear cell carcinoma (KIRC) can be triggered by the ...
In this paper, a review of the literature was performed to critically evaluate relevant published research on diagnosis and treatment of Madelung’s deformity. Madelung’s deformity is a metaphyseal dysplasia of the distal radius, where ...
Objective: To observe the clinical value of prognostic nutritional index (PNI) combined with carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 242 in early prediction of anastomotic leakage after radical gastrectomy for gastric cancer. Methods: ...
Purpose: This study aimed to investigate whether repetitive transcranial magnetic stimulation (rTMS) combined with acupuncture could alleviate pain in patients suffering from postherpetic neuralgia (PHN) by inhibiting NOD-like receptor 3 (NLRP3) inflammasome ...
Objective: To investigate the mechanism of the Yigu Decoction empirical formula in the treatment of knee osteoarthritis (KOA) using network pharmacology and molecular docking methods. Methods: The active ingredients and targets of Yigu Decoction were ...
Background: Magnetic resonance imaging (MRI) is commonly used to analyze the relationship between tumors and nerves before surgery. However, the application value of diffusion tensor imaging (DTI), diffusion weighted imaging (DWI), and post-processing ...
Chronic lymphocytic leukemia (CLL) is a common type of adult leukemia that occurs in Western countries, and its incidence has gradually increased in China in recent years. The characteristics of CLL are highly heterogeneous. Despite promising response ...
Patients with KRAS-mutated and microsatellite-stable (MSS) metastatic colorectal cancer (mCRC) often have limited options in salvage-line treatment. Reasonable combination strategy may be a valuable exploration. Here, we report a patient with KRAS-mutated ...
Objective: To analyze the role of health education in the management of chronic diseases in older people in the community and the countermeasures. Methods: After establishing a community health management model for chronic diseases of the elderly based ...
Objective: Plant-based natural antioxidants have a wide variety of biological activities with significant therapeutic value. Mangifera indica has been used traditionally to treat a variety of ailments in animals and human, but little is defined about ...
Objective: In this study, we explored the potential mechanisms and the signaling pathways involved in the treatment of Ulcerative Colitis (UC) with imiquimod (IMQ). Methods: The UC mouse model was established by treating C57BL/6J mice with 3% Dextran ...
Purpose: To analyze the effect of adjuvant rehabilitation training after calf contouring with botulinum toxin type A (BTX-A) injection. Methods: Clinical data of 48 female beauty seekers who underwent calf contouring at the Plastic Surgery Laser Center ...