Osteosarcoma (OS) is distinguished as a high-grade malignant tumor, characterized by rapid systemic metastasis, particularly to the lungs, resulting in very low survival rates. Understanding the complexities of tumor development and mutation is the need of the hour for the advancement of targeted therapies in cancer care. A significant innovation in this area is the use of...
Gold nanoparticles are widely used in biomedical applications due to their unique properties. However, traditional synthesis methods generate contaminants that cause cytotoxicity and compromise the biocompatibility of the nanomaterials. Therefore, green synthesis methods are essential to produce pure and biocompatible nanoparticles, ensuring their effectiveness in biomedical...
Because of their uniform and regular channels, adjustable pore size, large surface area, controllable wall composition, high hydrothermal stability, ease of functional modification, and good accessibility of larger reactant molecules, mesoporous siliceous SBA-15 is of excellent catalyst carrier that is highly versatile and has been used extensively to prepare a variety of...
We demonstrate unprecedented control and enhancement of thermal radiation using subwavelength conical membranes of silicon nitride. Based on fluctuational electrodynamics, we find that the focusing of surface phonon-polaritons along these membranes enhances their far-field thermal conductance by three orders of magnitude over the blackbody limit. Our calculations reveal a non...
Diabetic wounds with chronic infections present a significant challenge, exacerbated by the growing issue of antimicrobial resistance, which often leads to delayed healing and increased morbidity. This study introduces a novel silver-zinc oxide-eugenol (Ag+ZnO+EU) nanocomposite, specifically designed to enhance antimicrobial activity and promote wound healing. The nanocomposite...
Human lens epithelial cells (hLECs) are critical for lens transparency, and their aberrant metabolic activity and gene expression can lead to cataract. Intracellular delivery to hLECs, especially to sub-cellular organelles (e.g., mitochondrion and nucleus), is a key step in engineering cells for cell- and gene- based therapies. Despite a broad variety of nano- and microparticles...
Metastatic cancer cells undergo metabolic reprogramming, which involves changes in the metabolic fluxes, including endocytosis, nucleocytoplasmic transport, and mitochondrial metabolism, to satisfy their massive demands for energy, cell division, and proliferation compared to normal cells. We have previously demonstrated the ability of two different types of compounds to...
Phytonanoparticles have emerged as a promising class of biomaterials for enhancing bone regeneration and osseointegration, offering unique advantages in biocompatibility, multifunctionality, and sustainability. This comprehensive review explores the synthesis, characterization, and applications of phytonanoparticles in bone tissue engineering. The green synthesis approach...
Breast cancer is the most common cancer among women, with over 1 million new cases and around 400,000 deaths annually worldwide. This makes it a significant and costly global health challenge. Standard treatments like chemotherapy and radiotherapy, often used after mastectomy, show varying effectiveness based on the cancer subtype. Combining these treatments can improve outcomes...
In this study, firstly chitin was reacted with chloracetyl chloride to synthesize the macroinitiator chitinchloroacetate (Ch.ClAc). Then, graft copolymers of methacrylamide (MAM), diacetone acrylamide (DAAM), N-(4-nitrophenyl)acrylamide (NPA), and 2-hydroxyethyl methacrylate (HEMA) monomers were synthesized by atom transfer radical polymerization (ATRP). All of the polymers were...
Multifunctional membranes applied to biomedical materials become attractive to support the biological agents and increase their properties. In this study, biopolymeric fibers based on polycaprolactone (PCL) and pectin (PEC) were reinforced with faujasite zeolite (FAU) for cloxacillin antibiotic (CLX) loading. FAU with a high specific surface area (347 ± 8 m2 g−1), high...
Chemically tuned organic–inorganic hybrid halide perovskites based on bromide and chloride anions CH(NH2)2Pb(Br1−xClx)3 (CH(NH2)2+: formamidinium ion, FA) have been crystallized and investigated by neutron powder diffraction (NPD), single crystal X-ray diffraction (SCXRD), scanning electron microscopy (SEM) and UV–vis spectroscopy. FAPbBr3 and FAPbCl3 experience successive phase...
Integrating noble metal nanostructures, specifically silver nanoparticles, into sensor designs has proven to enhance sensor performance across key metrics, including response time, stability, and sensitivity. However, a critical gap remains in understanding the unique contributions of various synthesis parameters on these enhancements. This study addresses this gap by examining...
The increasing demand for magnetic iron oxide nanoparticles (IONPs) in biomedicine necessitates efficient and scalable production methods. Thermal decomposition offers excellent tailoring of the particle properties but its discontinuous batch-operation is restricting scale-up and industrial application. To overcome these challenges, several studies have demonstrated semi...
The study highlights the significant effects of Zn ions concentration on the optical properties of BaNi2-xZnxFe16O27 ferrites, emphasizing the tunability of the band gap through Zn doping and explores their potential to enhance their optical properties. The barium-nickel ferrite powder, with the composition BaNi2−xZnxFe16O27, was synthesized using the ceramic method. The effects...
The world is now facing a water scarcity crisis due to waste, pollution, and uneven distribution of freshwater resources, which are limited. Thus, the creation of innovative, economical, and effective methods for purifying water is crucial. Here, the photo-assisted degradation of methylene blue (MB) dye under visible light and UV was achieved by using RGO photocatalyst loaded...
Hybrid wastewater treatment systems offer viable solutions to enhance the removal of complicated contaminants from aqueous system. This innovation has opened new avenues for advanced wastewater treatment processes. Herein, a novel TiO2–ZnO functionalized coal fly ash-based ceramic membrane was fabricated by utilizing a combined pressing and sintering method. The intrinsic...
Acalabrutinib (ACP) is a first-line treatment for chronic lymphocytic leukemia but suffers from poor and variable oral bioavailability due to its pH-dependent solubility, CYP3A4 metabolism, and P-gp efflux. Thus, the objective of this study was to improve the solubility and dissolution behaviour, in turn enhancing bioavailability, by formulating solid lipid nanoparticles (SLNs...
Cervical cancer remains a significant health challenge in developing countries are high due to low HPV vaccination rates, delayed diagnosis, and restricted healthcare access. Metal nanomaterials, such as copper oxide (CuO) nanoparticles (NPs), have shown significant promise in cancer therapy due to their ability to induce apoptosis. 5-Fluorouracil (5-Fu) enhances the cytotoxic...
Glioblastoma (GBM) is an aggressive brain tumor characterized by cellular and molecular diversity. This diversity presents significant challenges for treatment and leads to poor prognosis. Surgery remains the primary treatment of choice for GBMs, but it often results in tumor recurrence due to complex interactions between GBM cells and the peritumoral brain zone. Phytochemicals...
Li4Ti5O12 (LTO) batteries are known for safety and long lifespan due to zero-strain and stable lattice. However, their low specific capacity and lithium-ion diffusion limit practical use. This study explored modifying LTO through yttrium doping by hydrothermal method to form Li4Y0.2Ti4.8O12 nanoparticles. This approach optimized electron and ion transport, markedly enhancing rate...
In vivo, molecular imaging is prevalent for biology research and therapeutic practice. Among advanced imaging technologies, photoacoustic (PA) imaging and sensing is gaining interest around the globe due its exciting features like high resolution and good (~ few cm) penetration depth. PA imaging is a recent development in ultrasonic technology that generates acoustic waves by...
Cancer is a deadly disease with complex pathophysiological nature and is the leading cause of death worldwide. Traditional diagnosis methods often detect cancer at a considerably critical stage and the conventional methods of treatment like chemotherapy, radiation therapy, targeted therapy, and immunotherapy have several limitations, multidrug resistance, cytotoxicity, and lack...
Nanomedicine, the most promising approach for regulated and targeted drug delivery, is frequently applied in cancer treatment. Essentially, accumulating evidence indicates that nanomedicine has positive results in the treatment of breast cancer (BC), with many BC patients benefiting from nanomedicine-related treatments. Currently, nanodrug delivery systems based on stimulus...