The aim of this study was to evaluate the effects of 15 saponins and flavonoids from the roots and aerial parts of C. bonus-henricus L. on non-enzymatic (Fe2+/AA)-induced lipid peroxidation in isolated rat liver microsomes. The production of MDA was used as a marker of lipid peroxidation. All saponins exhibited pronounced antioxidant activity (reducing MDA production by 17–23...
The analysis included 466 patients with myelofibrosis on treatment with ruxolitinib. The PFS at 12th, 20th, 30th, 40th, and 50th month was 88%, 83%, 75%, 65%, and 61% respectively. Median for PFS was reached at 73.5 months. OS median was reached at 48.2 months. OS at month 12th, 20th, 30th, and 40th month was 87%, 78%, 70%, and 56% respectively. Eligible patients for comparison...
Nitrofurazone is a synthetic semicarbazone from the nitrofuran class and exhibits activity against gram-positive and gram-negative bacteria. The aim of the current study includes the development and validation of a highly sensitive, fast, easy-to-perform, and non-destructive IR spectrophotometric method for the identification and quantification of nitrofurazone with respect to...
Breast cancer survivors frequently experience menopausal symptoms resulting from treatment-induced ovarian failure, ovarian suppression, and prolonged endocrine therapy. The symptoms may be abrupt and severe, substantially affecting quality of life and complicating survivorship care. Systemic menopausal hormone therapy is generally contraindicated in hormone receptor-positive...
Real-world evidence (RWE) complements randomized clinical trial data by demonstrating treatment effectiveness in routine practice and unselected populations. Despite the broad use of ribociclib, real-world data remain limited, particularly in Eastern Europe. This retrospective single-center analysis evaluated outcomes in Bulgarian patients treated with ribociclib and compared...
Mucuna pruriens (L.) DC, a member of the Fabaceae family, represents one of the most extensively studied species within the genus Mucuna. It is an annual, tropical, leguminous medicinal plant widely utilized in traditional Ayurvedic medicine throughout Asia and Africa. Globally, it is recognized as a plant employed in the management of Parkinson’s disease. It is also valued for...
Candida auris is an emerging, multidrug-resistant yeast that can cause severe and sometimes fatal infections. A literature search of the Web of Science, Scopus, and PubMed databases identified natural products from plant, microbial, and animal sources. These agents have shown varying degrees of activity against C. auris, ranging from growth inhibition to biofilm prevention or...
Background: Diabetic kidney disease (DKD) is a leading cause of chronic kidney disease progression and increased cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). Despite optimized standard therapy, substantial residual renal risk persists. Finerenone, a selective non-steroidal mineralocorticoid receptor antagonist, has demonstrated cardiorenal benefits in...
The application of transparent bioadhesive films is an aesthetic and patient-friendly solution for promoting the recovery of infections affecting the oral mucosa (e.g., on the lips, gums, and cheeks). Targeting the causative agent(s) of such infections is an even better alternative, offering not only protection, pain relief, and reduction of spreading but also actual healing...
Blood transfusions are essential for effective treatment and high-quality patient care. Screening donated blood for pathogens enables early detection of infections, reduces the risk of disease transmission, and enhances public trust in blood safety. Identifying viruses such as the hepatitis C virus (HCV) facilitates the timely initiation of direct-acting antiviral (DAA) therapy...
This study aimed to compare the antimetabolite effects of Portulaca oleracea (purslane) extract (EPO) and a commercial dietary supplement composed of chromium, cinnamon, and purslane extract in streptozotocin-induced diabetic spontaneously hypertensive rats (SHR). The study evaluated the impact of these bioactive substances on body weight and serum and liver biomarkers. Treatment...
Pulmonaria rubra Schott (Boraginaceae) is a scarcely investigated congener of the medicinal species P. officinalis. This study aimed to characterize the lipophilic constituents of the dichloromethane extract from P. rubra aerial parts (PR-DCM) and to evaluate its antioxidant and neuroprotective activity in vitro, as well as its effects on monoamine oxidase (MAO) and major...
In recent years, there has been a growing body of literature on how digital technologies enhance patient engagement through patient-reported outcomes (PROs). The evaluation of PROs related to patients’ experiences of diagnosis and treatment, as well as their interactions with health care professionals and the health care system, provides important insights into how digital...
Adverse drug reactions (ADRs) pose a significant patient-safety concern, contributing to substantial morbidity, mortality, and healthcare utilization. Source-grounded chatbots have the potential to enhance pharmacovigilance by improving access to regulated medicine information and reducing barriers to ADR reporting. We created a prototype of a web-based chatbot (PharmaBot...
The socioeconomic burden of end-stage kidney disease (ESKD) in Malaysia and Indonesia necessitates innovative care strategies. The TEAM-HD study assessed medication adherence and telepharmacy acceptance among hemodialysis patients in Selangor (Malaysia) and South Sulawesi (Indonesia). From April 2023 to April 2024, 131 patients (Malaysia: 71; Indonesia: 60), aged ≥ 18 years and...
Herpetic uveitis, most commonly caused by herpes simplex virus (HSV) and varicella-zoster virus (VZV), is a frequent cause of secondary glaucoma. Elevated intraocular pressure (IOP) in these patients is primarily due to inflammatory trabeculitis, trabecular meshwork obstruction, and steroid-induced mechanisms. IOP control is often challenging, and some cases require surgical...
Bexarotene is a clinically approved anticancer agent belonging to the retinoid class. Integrating the retinoid scaffold with a hydrazone moiety represents a promising strategy for modulating electronic properties relevant to receptor binding and desired biological activity. However, the electronic effects of halogen substitution within the retinoid–hydrazone framework have not...
Isatin derivatives have been at the forefront of pharmaceutical research, displaying a wide range of biological activities, including antioxidant, antimicrobial, and anticancer properties. In this study, twelve isatin-pyridine Schiff bases were evaluated using density functional theory (DFT) methods to examine the influence of pyridyl ring orientation (2-, 3-, and 4-aminopyridine...
Non-adherence to tuberculosis treatment is the main obstacle to its eradication worldwide, with 40% of patients reported in underdeveloped nations. The current study aimed to determine socio-demographic factors associated with non-adherents to TB treatment at a healthcare center in South Africa. A cross-sectional study was conducted on 65 patients undergoing treatment. Socio...
The development of an efficient reverse-phase high performance liquid chromatography (RP-HPLC) method is crucial for monitoring the synthetic process of N-pyrrolyl-hydrazone compounds with bioactive potential. This study outlines the optimization of chromatographic conditions, including stationary and mobile phases, to achieve optimal separation and resolution of target compounds...
Chronic myeloid leukaemia (CML) represents the first oncological disease in which a direct relationship between a genetic mutation and neoplasia formation has been established. The Philadelphia chromosome leads to the expression of a tyrosine kinase with constitutive activity, providing the basis for the development of targeted pharmacotherapy. The introduction of imatinib marked...
Background: Severe asthma is a heterogeneous condition in which biologic therapies targeting type 2 inflammation have substantially improved disease control. However, a proportion of patients fail to achieve a sustained response, necessitating biologic switching in routine clinical practice. Objective: Evaluate real-world patterns, clinical outcomes, and determinants of biologic...
Although postgraduate training in clinical pharmacy has been established in Bulgaria since 1986, the practical implementation and standardization of clinical pharmacy practice remain insufficiently studied and documented. This Delphi study explored barriers to introducing a national clinical pharmacy practice guideline. Eight clinical pharmacists from six university hospitals...
Aim: This study assessed the effects of pharmacy automation on dispensing efficiency, medication safety, and user satisfaction in hospital pharmacies across G20 countries. Methods: A systematic search of PubMed, Scopus, and ScienceDirect identified studies evaluating dispensing-related automation in hospital settings. Eligible studies were analyzed using Review Manager 5.4...
Retinopathy of prematurity (ROP) is one of the most serious eye diseases affecting prematurely born infants. Modern treatment methods, including laser photocoagulation, have significantly reduced the incidence of blindness and severe visual impairment due to tractional retinal detachment, macular folds, or excessive myopia. However, long-term complications are still observed in...