A cross-sectional online survey was conducted among adults in Saudi Arabia to explore public use of ChatGPT for medication-related information. A validated, self-administered questionnaire was distributed through social media platforms and analyzed using descriptive statistics and binary logistic regression. Among 475 respondents, nearly two-thirds reported using ChatGPT to...
Prescribing antibiotics for pediatric patients with respiratory tract infections (RTIs) remains poorly studied in many low- and middle-income countries. This study aims to evaluate the quality of antibiotic prescribing for in-hospital pediatric patients with RTIs, identify predictors of this practice, and evaluate patients’ clinical outcomes. A cross-sectional study was conducted...
Allergic rhinitis (AR) is a major public health problem with a growing global prevalence, currently affecting approximately 30% of the world population. There remains limited understanding of how local cytokine production patterns following nasal allergen challenge relate to clinical symptoms, particularly in the context of the late-phase allergic response. Interleukin-13 (IL-13...
Objective: The study was designed to evaluate the effect of medication management review service (MMR) provided by pharmacist on the medication adherence for females diagnosed with depression and anxiety in Jordan, and to estimate the effect of different patient factors on their medication adherence. Method: Recruited patients who visited an outpatient psychiatric clinic at the...
The prognosis of sepsis, a life-threatening organ dysfunction with high mortality, is closely related to the immune function of the host. It was found that the toll-like receptor (TLR) 7/8 signaling pathway could be activated to achieve the prevention and treatment of sepsis. Herein, a kind of immune-regulating complex is constructed by simple mixing R848, a TLR 7/8 agonist, with...
Linum alpinum L. is a promising source of arylnaphthalene lignans, including justicidin B (JB). In vitro root cultures (RC) of L. alpinum were investigated for JB accumulation and its modulation by methyl jasmonate (MeJA). JB content was quantified by LC-HRESI-MS over a 30-day cultivation period. The modulatory effect of MeJA was evaluated after the 5th day of application at...
This 6-month study evaluated the cost-effectiveness of an interprofessional collaboration (IPC) program for hemodialysis outpatients with end-stage renal disease (ESRD). We compared a control group (n = 100) with an IPC group (n = 96) at Dr. Pirngadi Hospital, Indonesia, from a payer’s perspective. The IPC team, including a nephrologist, nurses, and pharmacists, provided...
The mechanical behavior, formulation performance, and erythromycin release kinetics of hard-shell capsules prepared from gelatin, hydrolyzed carrageenan (HC), and hydrolyzed carrageenan–maltodextrin (HC-MD) systems were comparatively evaluated. Capsules were produced using a dip-coating method and assessed for weight variation, mechanical strength, degree of swelling...
This report presents a complex case of an 18-year-old patient with multiresistant nephrotic syndrome secondary to focal and segmental glomerulosclerosis and hyalinosis (FSGSH), characterized by massive proteinuria (47 to 11 g/24 h), severe hypoproteinemia (albumin 6–17 g/L), immunologic abnormalities (C3, IgM, and C1q deposits), dysregulation of the alternative complement pathway...
Background: Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but severe complication following SARS-CoV-2 infection. Early recognition and forecasting may support preparedness and clinical resource allocation. Objective: We aimed to model the temporal relationship between COVID-19 incidence and MIS-C cases using time series analysis. Materials and methods: We...
Typhoid fever has a substantial economic impact in developing countries, including in Indonesia. As the most cost-effective intervention to prevent typhoid fever, vaccination has not yet been introduced in the country. This study aimed to analyse the cost-effectiveness and budget impact of typhoid vaccination strategies, focusing on high-burden regions in Indonesia. This study...
Vaccination has been scientifically proven to be the safest and most effective means of protection against influenza and of limiting the spread of the virus that causes it. Based on an anonymous questionnaire-based survey conducted among 1038 Bulgarian citizens, we found that only 16.76% had been vaccinated against seasonal influenza, while only 26.69% expressed willingness to be...
Objective: This work aims to estimate the effectiveness of topically administered ezetimibe on an imiquimod-evoked psoriasis-like mouse model. Methods: Twenty-four albino mice were assorted equally into four groups (6 animals in every group), comprising controls, induction, calcipotriol 0.05% (standard drug), and ezetimibe 3%. The topical medications were administered for 7...
Hospital activities, and in-hospital activities in particular, represent one of the most resource-intensive parts of the health system, and their effectiveness depends to a significant extent on the rational management of financial costs. This study analyzes the dynamics of basic medical-economic indicators – average cost per patient, daily costs divided by the number of hospital...
Hospital care, and inpatient activity in particular, is a key component of the health system, providing comprehensive treatment and highly specialized, continuous care for patients. This study tracks the main trends and dynamics in the quality indicators of inpatient activity at the University Hospital “Tsaritsa Yoanna – ISUL” during the period 2013–2024. The results show...
Objective: Mobile health applications (mHealth apps) can support effective asthma self-management interventions, improving patients’ quality of life while reducing costs for healthcare systems. This article aims to identify trends in app features relevant to the future development of reliable mHealth asthma support applications that can meet the challenges of the new century...
Objective: Population aging in Europe, particularly in Bulgaria, where adults ≥ 65 years represent 24% of the population, increases risks related to multimorbidity, polypharmacy, potentially inappropriate prescribing (PIP), and potentially inappropriate medications (PIM). This study aimed to adapt the EU(7)-PIM List for the national context, assess national market availability of...
Psoriasis is a chronic autoimmune inflammatory skin condition characterized by uncontrolled keratinocyte proliferation and potential systemic manifestations. Its pathogenesis involves activation of both innate and adaptive immune responses, leading to an imbalance in inflammatory cytokines. Interleukin (IL)-12 and IL-23 are key cytokines in the pathophysiology of psoriasis and...
The safety profile of two newly synthesized series of hydrazone derivatives (7a–e and 8a–e) was studied in different liver-derived cell and subcellular culture models, i.e., isolated rat liver hepatocytes and microsomes, and the HepG2 cell line. The hydrazones, which have previously been reported to possess neuroprotective and antioxidant activity, were further assessed for...
Urachal carcinoma is a rare and aggressive tumor arising from the embryonic remnant connecting the bladder dome to the umbilicus. It accounts for less than 1% of bladder cancers and typically affects patients aged 52 to 59 years. Surgical resection with negative margins is the mainstay of treatment for localized disease, often involving urachal excision, partial or radical...
Ibuprofen (IBP), a BCS Class II drug, exhibits poor solubility and a high sticking tendency during compression in tablet manufacturing. This study presents a novel ultrasound-assisted cocrystallization method using nicotinamide (NIC) as a coformer at a 1:1 molar ratio in acetonitrile, followed by sonication at 50 kHz for 10–60 minutes. Differential scanning calorimetry and powder...
Wearable health-tracking technologies are increasingly incorporated into prenatal care to enable continuous, noninvasive monitoring of maternal and fetal health. Devices such as smartwatches, fitness trackers, smart rings, and medical-grade biosensors can collect longitudinal data on physiological parameters, including heart rate, physical activity, sleep patterns, and pregnancy...
Background: Cancer remains a major cause of mortality worldwide, with the PI3K/mTOR signaling pathway playing a crucial role in tumor progression, proliferation, and therapeutic resistance. Although several dual PI3K/mTOR inhibitors have been developed, their clinical outcomes remain limited due to poor bioavailability, significant toxicities, and rapid resistance. Molecular...
The poor intestinal permeability of sodium alendronate (NaALD), a BCS Class III drug, severely limits its oral bioavailability. The self-double-emulsifying drug delivery system (SDEDDS) formulation containing phosphatidylcholine (PLG 1.1) demonstrated its ability to form micro- and nano-emulsions under gastric and intestinal conditions, as well as superior permeation across a...
Introduction: Septic shock complicated by poststernotomy mediastinitis in patients with mechanical circulatory support devices is a rare and life-threatening condition associated with high mortality. Management is particularly challenging because of the presence of prosthetic material and the risk of device contamination. Case presentation: We report a 63-year-old man with end...