Background: Hepatocellular carcinoma (HCC), the most common primary liver malignancy, presents notable sex-based differences in incidence and progression. This study investigated gender-related variations in clinical, biological, and histopathological features among Algerian patients with HCC undergoing surgical resection, aiming to elucidate regional patterns and potential sex...
Background: Given the increasing population of older adults in the world and Iran, mental health issues, including depression, and smoking habits in this age group require particular attention. The present study aimed to investigate the relationship between smoking habits and depression in women and men over 50 years of age in the PoCOsteo study in Bushehr, Iran. Materials and...
Background: Acinetobacter baumannii causes numerous therapeutic problems in patients due to the presence of various effective factors that facilitate antibiotic resistance such as efflux pumps, beta-lactamase and the ability to form a strong biofilm. The aim of this study was to investigate the presence of AdeIJK efflux pump genes in clinical isolates of A. baumannii with...
Background: Sperm morphological abnormalities and aberrant chromatin maturation are considered important indicators of male fertility. Assessing sperm structural anomalies and DNA damage plays a critical role in evaluating male reproductive potential. This study aimed to investigate the association between sperm morphological abnormalities and DNA integrity in human sperm...
Background: Herpesviruses, a family of DNA viruses, cause various infections in humans and animals, affecting the skin and internal organs. Valacyclovir, a prodrug of acyclovir, is an effective antiviral drug widely used to treat diseases caused by herpesviruses. Importantly, valacyclovir can easily cross the placental barrier during pregnancy. This raises concerns about...
Background: Wilson's disease is one of the rare autosomal recessive genetic disorders caused by genetic mutation. This disease leads to abnormal copper accumulation in the liver, brain, cornea, and other organs, which can have serious consequences on health. Case presentation: The patient is a 47-year-old man complaining of memory impairment, hand tremors, dark-colored urine...
Background: Long COVID refers to the persistence of various symptoms weeks or months after the initial infection with the novel coronavirus (SARS-CoV-2), irrespective of the presence of the virus. Given the significance of long COVID on patients' quality of life and its implications for the healthcare system, this study aimed to investigate the respiratory, gastrointestinal, and...
Background: Constipation is a very common disorder in adults. The aim of this study is to determine the relationship between sleep hours during the week and weekends with constipation in individuals. Materials and Methods: This study is a clinical/experimental trial and was conducted on outpatients who referred to the gastroenterology department of Shahid Mustafa Hospital in Ilam...
Background: Hookah and cigarette smoke contain various pollutants, including toxic heavy metals such as arsenic, lead, and cadmium, which can pose a threat to the health of exposed individuals. Materials and Methods: This study aimed to assess occupational exposure by quantifying levels of metal biomarkers— including arsenic, lead, and cadmium—in urine samples collected from...
Background: Skin cancer is one of the most common malignancies worldwide, with increasing incidence and mortality rate. Knowledge of its epidemiological patterns is essential for prevention and control. Due to the limited evidence available in Bushehr city, this study aimed to investigate the prevalence and distribution of skin cancers over a ten-year period in this region...
Background: Wheat flour, a staple in the Iranian diet, serves as an ideal medium for fortification with micronutrients such as iron and folic acid. This study aimed to evaluate the effectiveness of the national fortification program by assessing iron and folic acid levels in wheat flour before and after fortification in Bushehr province. Materials and Methods: Sampling was...
Background: Glioma is one of the most prevalent and aggressive brain cancers, and its treatment poses significant challenges due to tumor heterogeneity and therapeutic resistance. Neoantigens, tumor-specific antigens arising from genetic mutations, have been recognized as promising targets for immunotherapy. This study employs advanced bioinformatics tools to identify potential...
Background: Thromboangiitis obliterans is a chronic inflammatory disease which involves small to medium blood vessels and is closely related to smoking. Case Presentation: The patient is a man who is almost 48 years old and has smoked for 20 years. He has complained of pain in the body and coldness and sores in the toes. He has not mentioned any specific autoimmune disease or...
Background: Low back pain (LBP) is a common condition, affecting approximately 637 million people worldwide. One possible contributing factor to LBP is the presence of Schmorl's nodes. The present study aimed to investigate the association between Schmorl's nodes and degenerative changes in the lumbar intervertebral discs in MRI scans of patients with LBP. Materials and Methods...
Background: Canine parvovirus (CPV) is one of the major agents of severe viral gastroenteritis in dogs. Although vaccines are available, the emergence of new serotypes and mutations in the VP2 protein can compromise vaccine efficacy. Therefore, identifying both conserved and serotype-specific immunogenic regions is crucial for the design of recombinant vaccines. This study aimed...
Background: Iron deficiency anemia is the most common nutritional problem among children. Despite the implementation of various programs, this problem has not yet been resolved and its prevalence in Iranian children under six years old has been reported to be 18.2%. The present study aimed to investigate factors associated with iron drop consumption in children aged 6 to 24...
Background: Neurodegenerative diseases cause dysfunction of the nervous system and the loss of neurons. Bone marrow-derived mesenchymal stem cells, under appropriate stimulation have the potential to differentiate into different progenitor cell types, including nerve cells. Spirulina algae has antioxidant, anti-inflammatory, and anticancer properties. This study evaluated the...
Background: Persian Gulf pearls, a valuable natural resource, have long held a prominent place in traditional Iranian medicine. The aim of the present study is to investigate the therapeutic applications of Persian Gulf pearls in traditional Iranian medicine and to uncover its novel medical uses. Materials and Methods: The present descriptive-analytical study was conducted using...
Background: People with disabilities are more vulnerable to accidents and disasters than the general population, and the assistance they receive is often inadequate. This scoping review aims to identify the factors contributing to their vulnerability and assess the needs of people with disabilities through synthesizing thematic method. This study discusses common disasters, such...
Background: The human immunodeficiency virus (HIV) remains a critical global public health challenge, contributing to a growing burden of comorbidities and diminished quality of life among affected individuals. This study aimed to examine the association between retention in HIV care programs and the occurrence of comorbidities, as well as its impact on viral load suppression...
Background: The Health Transformation Plan (HTP) is a comprehensive program aimed at improving Iran's healthcare system, with objectives including enhanced service accessibility, reduced treatment costs, improved service quality, and the realization of health equity. However, achieving these goals requires fundamental revisions in economic, structural, and social dimensions...
Background: Physical activity can slow body deterioration, enhance quality of life, and improve psychological well-being in older adults. The present study aimed to determine the effects of home-based supervised Otago exercises on the quality of life, psychological well-being, and social isolation of older adults in Bushehr city. Materials and Methods: This quasi-experimental...
Background: Blood flow restriction (BFR) combined with exercise has gained attention for enhancing the effects of exercise on cognitive function, particularly executive performance. Additionally, lactate, as a metabolic byproduct of exercise, affects the function of the nervous system. The aim of the present study is to examine the effect of acute resistance exercise combined...
Background: Breast cancer is one of the most common and fatal malignancies in women. The presence of cancer stem cells (CSCs), which play a crucial role in metastasis, therapeutic resistance, and disease recurrence, presents a major treatment challenge. Identifying CSCs-specific therapeutic targets through systems biology approaches can lead to more effective treatment strategies...
Background: Delirium is one of the devastating complications of hospitalization in intensive care units. The present study aimed to determine the effect of a multifactorial intervention on the incidence of delirium in intensive care units of Zahedan teaching hospitals. Materials and Methods: This was a single-blind, controlled, clinical trial conducted on 94 patients hospitalized...