Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer.

Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer Christopher A. Maxwell1*¤a, Javier Benı́tez2,3, Laia Gómez-Baldó1,4, Ana Osorio2,3, Núria Bonifaci1,4,5, Ricardo Fernández-Ramires2,3, Sylvain V. Costes6, Elisabet Guinó4,5, Helen Chen7, Gareth J. R. Evans7, Pooja Mohan7, Isabel Català8, Anna Petit8, Helena Aguilar1, Alberto Villanueva1, Alvaro Aytes1, Jordi Serra-Musach1,5, Gad Rennert9, Flavio Lejbkowicz9, Paolo Peterlongo10, Siranoush Manoukian11, Bernard Peissel11, Carla B. Ripamonti10,11, Bernardo Bonanni12, Alessandra Viel13, Anna Allavena14, Loris Bernard15, Paolo Radice10, Eitan Friedman16,17, Bella Kaufman16, Yael Laitman16, Maya Dubrovsky16, Roni Milgrom16, Anna Jakubowska18, Cezary Cybulski18, Bohdan Gorski18, Katarzyna Jaworska18, Katarzyna Durda18, Grzegorz Sukiennicki18, Jan Lubiński18, Yin Yao Shugart19, Susan M. Domchek20, Richard Letrero20, Barbara L. Weber20¤b, Frans B. L. Hogervorst21, Matti A. Rookus22, J. Margriet Collee23, Peter Devilee24, Marjolijn J. Ligtenberg25, Rob B. van der Luijt26, Cora M. Aalfs27, Quinten Waisfisz28, Juul Wijnen29, Cornelis E. P. van Roozendaal30, HEBON31, EMBRACE32, Douglas F. Easton32, Susan Peock32, Margaret Cook32, Clare Oliver32, Debra Frost32, Patricia Harrington33, D. Gareth Evans34, Fiona Lalloo34, Rosalind Eeles35, Louise Izatt36, Carol Chu37, Diana Eccles38, Fiona Douglas39, Carole Brewer40, Heli Nevanlinna41, Tuomas Heikkinen41, Fergus J. Couch42, Noralane M. Lindor43, Xianshu Wang42, Andrew K. Godwin44, Maria A. Caligo45, Grazia Lombardi45, Niklas Loman46, Per Karlsson47, Hans Ehrencrona48, Anna von Wachenfeldt49, SWE-BRCA50, Rosa Bjork Barkardottir51, Ute Hamann52, Muhammad U. Rashid53, Adriana Lasa54, Trinidad Caldés55, Raquel Andrés56, Michael Schmitt57, Volker Assmann58, Kristen Stevens59, Kenneth Offit60, João Curado61, Hagen Tilgner61, Roderic Guigó61, Gemma Aiza1, Joan Brunet62, Joan Castellsagué62, Griselda Martrat1, Ander Urruticoechea1, Ignacio Blanco62, Laima Tihomirova63, David E. Goldgar64, Saundra Buys65, Esther M. John66, Alexander Miron67, Melissa Southey68, Mary B. Daly69, BCFR70, Rita K. Schmutzler71, Barbara Wappenschmidt71, Alfons Meindl72, Norbert Arnold73, Helmut Deissler74, Raymonda Varon-Mateeva75, Christian Sutter76, Dieter Niederacher77, Evgeny Imyamitov78, Olga M. Sinilnikova79,80, Dominique Stoppa-Lyonne81, Sylvie Mazoyer80, Carole Verny-Pierre80, Laurent Castera81, Antoine de Pauw81, Yves-Jean Bignon82, Nancy Uhrhammer82, Jean-Philippe Peyrat83, Philippe Vennin84, Sandra Fert Ferrer85, Marie-Agnès CollongeRame86, Isabelle Mortemousque87, GEMO Study Collaborators88, Amanda B. Spurdle89, Jonathan Beesley89, Xiaoqing Chen89, Sue Healey89, kConFab, Mary Helen Barcellos-Hoff6¤c, Marc Vidal91, Stephen B. Gruber92, Conxi Lázaro62, Gabriel Capellá62, Lesley McGuffog32, Katherine L. Nathanson20, Antonis C. Antoniou32, Georgia Chenevix-Trench89, Markus C. Fleisch93, Vı́ctor Moreno4,5, Miguel Angel Pujana1,4,5* 1 Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet, Catalonia, Spain, 2 Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain, 3 Biomedical Research Centre Network for Rare Diseases, Spain, 4 Biomedical Research Centre Network for Epidemiology and Public Health, Spain, 5 Biomarkers and Susceptibility Unit, Catalan Institute of Oncology, IDIBELL, L’Hospitalet, Catalonia, Spain, 6 Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, 7 Child and Family Research Institute, Vancouver, British Columbia, Canada, 8 Department of Pathology, University Hospital of Bellvitge, IDIBELL, L’Hospitalet, Catalonia, Spain, 9 CHS National Cancer Control Center, Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel, 10 Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori, and IFOM Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy, 11 Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy, 12 Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy, 13 Division of Experimental Oncology 1, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy, 14 Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy, 15 Department of Experimental Oncology, Istituto Europeo di Oncologia, and Consortium for Genomics Technology (Cogentech), Milan, Italy, 16 The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, Israel, 17 Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel, 18 International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland, 19 Unit of Statistical Genetics, Division of Intramural Research Program, National Institute of Mental Health, National Institute of Health, Bethesda, Maryland, United States of America, 20 Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, 21 Family Cancer Clinic, Department of Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands, 22 Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands, 23 Department of Clinical Genetics, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands, 24 Department of Genetic Epidemiology, Leiden University Medical Center, Leiden, the Netherlands, 25 Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands, 26 Department of Clinical Molecular Genetics, Utrecht University PLoS Biology | www.plosbiology.org 1 November 2011 | Volume 9 | Issue 11 | e1001199 BRCA1-RHAMM and Breast Carcinogenesis Medical Center, Utrecht, the Netherlands, 27 Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands, 28 Department of Clinical Genetics, VU University Medical Center, Amsterdam, the Netherlands, 29 Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands, 30 Department of Clinical Genetics, University Medical Center, Maastricht, the Netherlands, 31 Hereditary Breast and Ovarian Cancer Group, the Netherlands, 32 Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom, 33 Department of Oncology, University of Cambridge, Cambridge, United Kingdom, 34 Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, 35 The Oncogen (...truncated)