2F. COUP-TF-like receptors in GtoPdb v.2023.1
IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F95/2023.1
2F. COUP-TF-like receptors in GtoPdb v.2023.1
Ming-Jer Tsai1 and Sophia Y. Tsai1
1. Baylor College of Medicine, USA
Abstract
COUP-TF-like receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone
Receptors [7, 2]) have yet to be officially paired with an endogenous ligand.
Contents
This is a citation summary for 2F. COUP-TF-like receptors in the Guide to Pharmacology database (GtoPdb). It
exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database
by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which
are given here under database links.
GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a
reference work which is most usefully represented as an on-line database. As in any publication this work
should be appropriately cited, and the papers it cites should also be recognized. This document provides a
citation for the relevant parts of the database, and also provides a reference list for the research cited by
those parts. For further details see [10].
Please note that the database version for the citations given in GtoPdb are to the most recent preceding
version in which the family or its subfamilies and targets were substantially changed. The links below are to
the current version. If you need to consult the cited version, rather than the most recent version, please
contact the GtoPdb curators.
Database links
2F. COUP-TF-like receptors
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=95
Introduction to 2F. COUP-TF-like receptors
https://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=95
Receptors
COUP-TF1
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=617
COUP-TF2
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=618
V-erbA-related gene
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=619
References
1. Ahn MJ, Nason-Burchenal K, Moasser MM and Dmitrovsky E. (1995) Growth suppression of acute
promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or
PML. Oncogene 10: 2307-14 [PMID:7784078]
2. Alexander SPH, Cidlowski JA, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding
SD and Pawson AJ et al.. (2019) THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Nuclear hormone
receptors. Br J Pharmacol 176 Suppl 1: S229-S246 [PMID:31710718]
3. Alfano C, Viola L, Heng JI, Pirozzi M, Clarkson M, Flore G, De Maio A, Schedl A, Guillemot F and Studer
M. (2011) COUP-TFI promotes radial migration and proper morphology of callosal projection neurons
by repressing Rnd2 expression. Development 138: 4685-97 [PMID:21965613]
4. Armentano M, Chou SJ, Tomassy GS, Leingärtner A, O'Leary DD and Studer M. (2007) COUP-TFI
regulates the balance of cortical patterning between frontal/motor and sensory areas. Nat Neurosci 10:
1277-86 [PMID:17828260]
5. Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE and Leid M. (2000) Isolation of a novel
family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken
ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. J Biol Chem
275: 10315-22 [PMID:10744719]
6. Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P and Leid M. (1999) Heterodimeric
interactions between chicken ovalbumin upstream promoter-transcription factor family members
ARP1 and ear2. J Biol Chem 274: 14331-6 [PMID:10318855]
7. Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G, Perlmann T, Renaud JP, Schwabe J,
Sladek F, Tsai MJ and Laudet V. (2006) International Union of Pharmacology. LXVI. Orphan nuclear
receptors. Pharmacol Rev 58: 798-836 [PMID:17132856]
8. Bonnardeaux A, Davies E, Jeunemaitre X, Féry I, Charru A, Clauser E, Tiret L, Cambien F, Corvol P and
Soubrier F. (1994) Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension.
Hypertension 24: 63-9 [PMID:8021009]
9. Bosch DG, Boonstra FN, Gonzaga-Jauregui C, Xu M, de Ligt J, Jhangiani S, Wiszniewski W, Muzny DM,
Yntema HG and Pfundt R et al.. (2014) NR2F1 mutations cause optic atrophy with intellectual disability.
Am J Hum Genet 94: 303-9 [PMID:24462372]
10. Buneman P, Christie G, Davies JA, Dimitrellou R, Harding SD, Pawson AJ, Sharman JL and Wu Y. (2020)
Why data citation isn't working, and what to do about it Database 2020 [PMID:32367113]
11. Chan CM, Fulton J, Montiel-Duarte C, Collins HM, Bharti N, Wadelin FR, Moran PM, Mongan NP and
Heery DM. (2013) A signature motif mediating selective interactions of BCL11A with the NR2E/F
subfamily of orphan nuclear receptors. Nucleic Acids Res 41: 9663-79 [PMID:23975195]
12. Chen J, Cooper AD and Levy-Wilson B. (1999) Hepatocyte nuclear factor 1 binds to and transactivates
the human but not the rat CYP7A1 promoter. Biochem Biophys Res Commun 260: 829-34
[PMID:10403849]
13. Chu K, Boutin JM, Breton C and Zingg HH. (1998) Nuclear orphan receptors COUP-TFII and Ear-2:
presence in oxytocin-producing uterine cells and functional interaction with the oxytocin gene
promoter. Mol Cell Endocrinol 137: 145-54 [PMID:9605516]
14. Connor H, Nornes H and Neuman T. (1995) Expression screening reveals an orphan receptor chick
ovalbumin upstream promoter transcription factor I as a regulator of neurite/substrate-cell contacts
and cell aggregation. J Biol Chem 270: 15066-70 [PMID:7797489]
15. Cooney AJ, Leng X, Tsai SY, O'Malley BW and Tsai MJ. (1993) Multiple mechanisms of chicken
ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the
vitamin D, thyroid hormone, and retinoic acid receptors. J Biol Chem 268: 4152-60 [PMID:8382695]
16. Cooney AJ, Tsai SY, O'Malley BW and Tsai MJ. (1992) Chicken ovalbumin upstream promoter
transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to
repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors. Mol Cell
Biol 12: 4153-63 [PMID:1324415]
17. Crestani M, Sadeghpour A, Stroup D, Galli G and Chiang JY. (1998) Transcriptional activation of the
cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors. J Lipid Res 39: 2192-200
[PMID:9799805]
18. De Martino MU, Alesci S, Chrousos GP and Kino T. (2004) Interaction of the glucocorticoid receptor and
the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the
actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism. Ann N Y Acad Sci 1024:
72-85 [PMID:15265774]
19. Ge R, Rhee M, Malik S and Karathanasis SK. (1994) Transcriptional repression of apolipoprotein AI gene
expression by orphan receptor ARP-1. J Biol Chem 269: 13185-92 [PMID:8175747]
20. Hall RK, Sladek FM and Granner DK. ( (...truncated)
