Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group

Acta Neuropathologica, Feb 2014

Medulloblastoma is curable in approximately 70 % of patients. Over the past decade, progress in improving survival using conventional therapies has stalled, resulting in reduced quality of life due to treatment-related side effects, which are a major concern in survivors. The vast amount of genomic and molecular data generated over the last 5–10 years encourages optimism that improved risk stratification and new molecular targets will improve outcomes. It is now clear that medulloblastoma is not a single-disease entity, but instead consists of at least four distinct molecular subgroups: WNT/Wingless, Sonic Hedgehog, Group 3, and Group 4. The Medulloblastoma Down Under 2013 meeting, which convened at Bunker Bay, Australia, brought together 50 leading clinicians and scientists. The 2-day agenda included focused sessions on pathology and molecular stratification, genomics and mouse models, high-throughput drug screening, and clinical trial design. The meeting established a global action plan to translate novel biologic insights and drug targeting into treatment regimens to improve outcomes. A consensus was reached in several key areas, with the most important being that a novel classification scheme for medulloblastoma based on the four molecular subgroups, as well as histopathologic features, should be presented for consideration in the upcoming fifth edition of the World Health Organization’s classification of tumours of the central nervous system. Three other notable areas of agreement were as follows: (1) to establish a central repository of annotated mouse models that are readily accessible and freely available to the international research community; (2) to institute common eligibility criteria between the Children’s Oncology Group and the International Society of Paediatric Oncology Europe and initiate joint or parallel clinical trials; (3) to share preliminary high-throughput screening data across discovery labs to hasten the development of novel therapeutics. Medulloblastoma Down Under 2013 was an effective forum for meaningful discussion, which resulted in enhancing international collaborative clinical and translational research of this rare disease. This template could be applied to other fields to devise global action plans addressing all aspects of a disease, from improved disease classification, treatment stratification, and drug targeting to superior treatment regimens to be assessed in cooperative international clinical trials.

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Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group

Nicholas G. Gottardo 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Jordan R. Hansford 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Jacqueline P. McGlade 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Frank Alvaro 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 David M. Ashley 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Simon Bailey 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 David L. Baker 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Franck Bourdeaut 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 YoonJae Cho 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Moira Clay 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Steven C. Clifford 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Richard J. Cohn 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Catherine H. Cole 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Peter B. Dallas 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Peter Downie 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Franois Doz 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 David W. Ellison 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Raelene Endersby 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Paul G. Fisher 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Timothy Hassall 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 John A. Heath 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Hilary L. Hii 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 David T. W. Jones 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Reimar Junckerstorff 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Stewart Kellie 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Marcel Kool 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Rishi S. Kotecha 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Peter Lichter 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Stephen J. Laughton 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Sharon Lee 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Geoff McCowage 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Paul A. Northcott 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 James M. Olson 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Roger J. Packer 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Stefan M. Pfister 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Torsten Pietsch 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Barry Pizer 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Scott L. Pomeroy 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Marc Remke 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Giles W. Robinson 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Stefan Rutkowski 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Tobias Schoep 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Anang A. Shelat 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Clinton F. Stewart 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Michael Sullivan 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Michael D. Taylor 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Brandon Wainwright 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Thomas Walwyn 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 William A. Weiss 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Dan Williamson 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 Amar Gajjar 0 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 26 27 28 0 J. R. Hansford C. H. Cole R. Junckerstorff R. S. Kotecha S. Lee t . Walwyn princess Margaret Hospital for Children , perth, Australia 1 N. g. gottardo J. p . Mcglade M. Clay p . B. Dallas R. endersby H. L. Hii R. S. Kotecha t . Schoep t elethon Institute for Child Health Research, the University of Western Australia , perth, Australia 2 ) Department of paediatric Oncology/Haematology, princess Margaret Hospital for Children , perth, WA, Australia 3 Y.-J. Cho p. g. Fisher Stanford University School of Medicine , Stanford, CA, USA 4 F. Bourdeaut F. Doz Curie Institute , paris, France 5 D. L. Baker pathWest, perth, Australia 6 S. Bailey S. C. Clifford D. Williamson Northern Institute for Cancer Research, Newcastle University , Newcastle, UK 7 D. M. Ashley Barwon Health, Andrew Love Cancer Centre , geelong, Australia 8 F. Alvaro John Hunter Children's Hospital , Newcastle, Australia 9 R. J. packer Children's National Medical Center , Washington, D.C., USA 10 p. Downie Monash Children's Hospital, Southern Health , Melbourne, Australia 11 J. M. Olson Fred Hutchinson Cancer Research Center, University of Washington , Seattle, WA, USA 12 C. H. Cole University of Western Australia , perth, Australia 13 R. J. Cohn Sydney Children's Hospital Network , Sydney, Australia 14 t . pietsch University of Bonn , Bonn, germany 15 S. J. Laughton Starship Children's Hospital , Auckland, New Zealand 16 S. Kellie g. McCowage the Children's Hospital at Westmead , Sydney, Australia 17 R. Junckerstorff pathWest Neuropathology, Royal perth Hospital , perth, Australia 18 t . Hassall Royal Children's Hospital , Brisbane, Australia 19 D. W. ellison A. A. Shelat C. F. Stewart St. Jude Children's Research Hospital , 262 Danny thomas place, Memphis, tN, USA 20 F. Doz University paris Descartes Sorbonne paris Cite , paris, France 21 p. Downie J. A. Heath Royal Children's Hospital , Melbourne, Australia 22 S. Rutkowski University Medical Center Hamburg-eppendorf , Hamburg, germany 23 g. W. Robinson A. gajjar ( 24 S. L. pomeroy Boston Children's Hospital, Harvard Medical School , Boston, MA, USA 25 ) Department of Oncology , Mail Stop 260, St. Jude Children's Research Hospital , 262 Danny thomas place, Memphis, tN 38105, USA 26 W. A. Weiss University of California , San Francisco, San Francisco, CA, USA 27 B. Wainwright University of Queensland , Brisbane, Australia 28 M. Sullivan Christchurch Hospital , Christchurch, New Zealand Medulloblastoma is curable in approximately 70 % of patie (...truncated)


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Nicholas G. Gottardo, Jordan R. Hansford, Jacqueline P. McGlade. Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group, Acta Neuropathologica, 2014, pp. 189-201, Volume 127, Issue 2, DOI: 10.1007/s00401-013-1213-7