OMICS AND PROGNSTIC MARKERS

Neuro-Oncology, Nov 2013

Although histopathological diagnosis is essential in decision of therapeutic strategy for gliomas, sometimes the tumors diagnosed in one histological entity show thoroughly different clinical courses. This phenomenon is believed to be due primarily to the presence of the genetic subgroup. In fact, relationship between treatment response and certain genetic characteristics is indicated (e.g. better chemosensitivity in glioma with losses of 1p/19q (−1p/19q)). It is highly likely that genetic classification of glioma is useful to select the adjuvant treatment. Additionally, gain of 7q (+7q) and −1p/19q are early events in 2 distinct tumor lineages, astrocytic tumors and oligodendroglial tumors, respectively, and these tumors obtain additional genetic aberration (−9p, 10q) with tumor progression. On the other hand, concerning the tumors without +7q or −1p/19q, little is known about clinically important genetic aberration. Therefore the study on such tumors could provide useful information for the prognosis prediction and the determination of treatment strategy. METHODS: We selected 39 cases of gliomas without +7q or −1p/19q from 200 adult supratentorial glioma cases surgically treated and analyzed chromosomal DNA copy number aberrations (CNAs) by comparative genomic hybridization (CGH) from 2005 to 2012. We correlated clinical features of these tumors with histological characteristics, CNAs and IDH1 status. RESULTS: The clinical course of gliomas without +7q or −1p/19q was not correlated with additional genetic aberration of -9p or 10q, which have been known as genetic markers for poor prognosis, and absence of +7q or −1p/19q was maintained at the time of recurrence. The tumors without +7q or −1p/19q showed relatively favorable prognosis although mutation of IDH1 was infrequent in these tumors (35.8 %). CONCLUSION: The gliomas without +7q or −1p/19q have clinical features distinct from the +7q and −1p/19q gliomas. Prognostic markers for each subgroups could help establish therapeutic strategy against the tumor.

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OMICS AND PROGNSTIC MARKERS

0 OM-003. MOLECULAR FEATURES OF ADULT PATIENTS WITH GANGLIOGLIOMAS Shlomit Yust-Katz , Mark Anderson, Adriana Olar, Agda Eterovic, Nader Ezzeddine, Ken Chen, Hao Zhao, Gregory Fuller, Kenneth Aldape , and John de Groot; The UT MD Anderson Cancer Center , Houston, TX , USA 1 Ludwig Maximilians Universit a t M u nchen , M u nchen , Germany 2 OM-002. MOLECULAR CHARACTERIZATION OF 11p-DELETED DIFFUSE LOW-GRADE GLIOMAS Agusti Alentorn 3 Helmholtz Zentrum M u nchen , Neuherberg , Germany 4 Department of Neurological Surgery, University of California, San Francisco , San Francisco, CA , USA 5 OM-001. CONSIDERATION OF RELATIONSHIPS BETWEEN GENETIC ABNORMALITY AND CLINICAL PICTURE INGLIOMA WITHOUT 1 7 AND 2 1p/19q Kazuhide Adachi 6 Cardiovascular Research Institute, UCSF , San Francisco, CA , USA 7 Institute of Human Genetics, UCSF , San Francisco, CA , USA 8 Brain Tumor Research Center, UCSF , San Francisco, CA , USA 9 Helen Diller Family Comprehensive Cancer Center, UCSF , San Francisco, CA , USA 10 OM-004. CLONAL EXPANSIONS AND EVOLVING SUBPOPULATIONS IN GLIOBLASTOMA MULTIFORME Noemi Andor 11 Jawaharlal Nehru Centre for Advanced Scientific Research , Bangalore , India 12 Indian Institute of Science , Bangalore , India 13 National Institute of Mental Health and Neurosciences , Bangalore , India 14 OM-005. NOVEL GENES AND GENE SIGNATURE IN PROGNOSTICATION OF GLIOBLASTOMA: POTENTIAL TARGETS AND PATHWAY IDENTIFICATION Arimappamagan Arivazhagan 15 Sri SatyaSai Institute of Higher Medical Sciences , Bangalore , India 16 Acibadem University School of Medicine , Istanbul , Turkey 17 OM-014. GENOMIC ANALYSIS OF TRAF7-ONLY MUTANT MENINGIOMAS REVEALS NOVEL DRIVER MUTATIONS Victoria Clark 18 Memorial Sloan-Kettering Cancer Center , New York, NY , USA 19 Yale University School of Medicine , New Haven, CT , USA 20 OM-010. LOSS OF CIC AND FUBP1 EXPRESSIONS ARE POTENTIAL MARKERS OF SHORTER TIME TO RECURRENCE IN OLIGODENDROGLIAL TUMORS Aden Ka-Yin Chan 21 University Hospital of Bonn , Bonn , Germany 22 University Hospital of Cologne , Cologne , Germany 23 Bahcesehir University School of Medicine , Istanbul , Turkey 24 OM-030. EXPRESSION AND PROGNOSTIC SIGNIFICANCE OF CYSTEINE-RICH PROTEIN 61 IN GLIOBLASTOMA Joji Ishida , Kazuhiko Kurozumi, Tomotsugu Ichikawa, Manabu Onishi, Kentaro Fujii, Yosuke Shimazu, Tetsuo Oka , and Isao Date; Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan 25 Department of Biostatistics, University of West of England , Bristol , UK 26 OM-029. MGMT PROMOTER METHYLATION IS PRESENT IN LOW GRADE GLIOMA (WHO GRADE II/III) AND GLIOBLASTOMA MULTIFORME IN THE ABSENCE OF IDH MUTATIONS Harry R Haynes 27 Bristol Genetics Laboratory, Southmead Hospital , North Bristol NHS Trust, Bristol , UK 28 Department of Neuropathology and Brain Tumour Research Group, Frenchay Hospital , North Bristol NHS Trust, Bristol , UK 29 OM-028. EGFR AND EGFRvIII EXPRESSION IN GLIOBLASTOMA Claire Faulkner 30 Neuro-oncology Department, Bristol Haematology and Oncology Centre , Bristol , UK 31 OM-038. IDENTIFICATION OF CANDIDATE GENES ASSOCIATED WITH MALIGNANT TRANSFORMATION OF IDH-MUTATED LOW-GRADE ASTROCYTOMAS USING GENOME-WIDE COPY NUMBER VARIATION ANALYSIS Tareq A Juratli 32 The Ohio State University , Arthur G. James Comprehensive Cancer Center and Richard L. Solove Research Institute, Department of Radiation Oncology , Columbus, OH , USA 33 OM-036. RECEPTOR/RAS/PI3K/Akt/mTOR VARIATIONS IN Akt PATHWAY SUBTYPES SUGGEST THERAPEUTIC ALTERNATIVES Anna Joy 34 Technical University Dresden, University Hospital Dresden, Department of Neuropathology , Dresden , Germany 35 Technical University Dresden, University Hospital Dresden, Department of Neurosurgery , Dresden , Germany 36 OM-035. THE MEDULLOBLASTOMA METHYLOME REVEALS NEW EPIGENETIC REGULATORY MECHANISMS David T. W. Jones 37 University of Arizona College of Medicine - Phoenix , Phoenix, AZ , USA 38 The Translational Genomics Research Institute , Phoenix, AZ , USA 39 The Ohio State University, Center of Biostatistics , Columbus, OH , USA 40 OM-042. PROGNOSTIC VALUES OF LONG NON-CODING RNA SIGNATURES IN GLIOBLASTOMA MULTIFORME Xiao-qin Zhang 41 OM-041. GENOME-WIDE CNV ANALYSIS IDENTIFIES LOCI PUTATIVELY ASSOCIATED WITH DELAYED TIME TO FIRST RECURRENCE IN IDH-MUTANT LOW-GRADE ASTROCYTOMAS Tim Lautenschlaeger 42 Department of Statistics and Actuarial Science, Faculty of Science, The University of Hong Kong , Hong Kong , Hong Kong 43 Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital , Hong Kong , Hong Kong 44 OM-039. IDH1 STATUS AS A DIAGNOSTIC AND PROGNOSTIC MARKER FOR MALIGNANT ASTROCYTOMAS WITH LIMITED HISTOLOGICAL SPECIMEN: THE ROLE OF SURGICAL RESECTION, PATHOLOGICAL ANALYSIS AND MOLECULAR TESTING Betty YS Kim 45 Harvard Medical School, Massachusetts General Hospital , Boston, MA , USA 46 Departments of Neurosurgery and Tumor Biology, University Medical Center Hamburg-Eppendorf , Hamburg , Germany 47 PEPperPRINT GmbH , Heidelberg , Germany 48 Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg , Heidelberg , Germany 49 OM-050. IDENTIFICATION OF PROGNOSTIC SERUM-ANTIBODIES AGAINST GLIOBLASTOMA-ASSOCIATED ANTIGENS Andreas Mock 50 Department of Neurosurgery, Klinikum Grosshadern, Ludwig-Maximilians-University , Munich , Germany 51 Spanish National Cancer Research Centre , Madrid , Spain 52 Dana-Farber Cancer Institute , Boston, MA , USA 53 OM-056. HUMAN NON-GCIMP GLIOBLASTOMA SUBTYPES EVOLVE FROM A COMMON PRONEURAL-LIKE PRECURSOR GLIOMA Tatsuya Ozawa 54 Karolinska Institute, Center for Molecular Medicine , Stockholm , Sweden 55 Karolinska University Hospital, Department of Neurology , Stockholm , Sweden 56 OM-066. LOW LEVELS OF HUMAN CYTOMEGALOVIRUS INFECTION IN GLIOBLASTOMA MULTIFORME ASSOCIATES WITH PATIENT SURVIVAL; A PROSPECTIVE STUDY Giuseppe Stragliotto 57 OM-073. GENOMIC CHARACTERIZATION OF SPATIAL AND TEMPORAL HETEROGENEITY OF GLIOBLASTOMA MULTIFORME Hoon Kim 58 OM-072. LANDSCAPE OF CHROMOSOMAL COPY NUMBER ABERRATIONS (CNAS) IN GLIONEURONAL TUMORS (GNTS): RELATIVELY FREQUENT GAIN OF CHROMOSOME 5 AND/OR 7; CHROMOTHRIPSIS IN SUBSET OF CASES A Prabowo 59 Radboud University Nijmegen Medical Centre , Nijmegen , The Netherlands 60 Swammerdam Insitute for Life Sciences, Centre for Neuroscience, University of Amsterdam , Amsterdam , The Netherlands 61 Emory University , Atlanta, GA , USA 62 Henry Ford Health System , Detroit, MI , USA 63 The University of Texas MD Anderson Cancer Center , Houston, TX , USA 64 SEIN- Stichting Epilepsie Instellingen Nederland , Heemstede , The Netherlands 65 Dept of Clinical Neurophysiology, University Medical Center Utrecht , Utrecht , The Netherlands 66 Dept of Pathology,University Medical Center Utrecht , Utrecht , The Netherlands 67 The Broad Institute of Harvard and MIT , Cambridge, MA , USA 68 Case Western Reserve University School of Med (...truncated)


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