Different organ perturbation and multiple complications might occur after cardiopulmonary bypass (CPB). A variety of solutions might be used for pump priming with different advantages and disadvantages. The advantage of fresh frozen plasma (FFP) inclusion ...
Background: There is an on-going debate on how best to test toxic indoor air. Toxicological methods based on condensed water samples and cell culture technique are newly introduced research tools which were tested in this study. Methods: Pupils (n=47) ...
Background: In the worldwide, there are the pandemic of the virus coronavirus disease 2019 (COVID-19) and there is no approved treatment for this disease. Case presentation: This study reported a new case with COVID 19 with neurological symptoms such ...
Rationale: MicroRNAs (miRNAs) are emerging as important regulators of allergic inflammation and potential therapeutic targets. We sought to identify which miRNAs are expressed in CD4[+] T-cells and determine whether allergic stimuli or glucocorticoids ...
The aim of this study is to determine the antibacterial activity of Piper betle L. leaf extract on inhibiting Staphylococcus aureus in conjunctivitis patient. This study follows a post-test only group experimental design. Antibacterial activities of five ...
Background: Acne vulgaris is a common complication that patients referred to dermatologist, also there are medications to manage of this such as isotretinoin, and incidence of low back pain in these patients is more than general population, so in this ...
Background: Recently, the use of posterior mucus flap has been introduced as a new technique for DCR, which has had a great success, as well as bone overlapping and minimal postoperative obstruction. Considering the need for these flaps to have a very ...
B-cell mediated autoimmune diseases of central nervous system (CNS) put a heavy burden on different aspects of society and economy. Taken together, there are different types of autoimmune diseases in which B-cells play an important role and affect CNS ...
Background: Core needle biopsy (CNB) method is a common method and a gold standard for the diagnosis of breast lesions. The purpose of this study was to compare the results of visual inspection of ultrasound guided biopsy specimens with pathologic outcomes ...
Background: Epilepsy is a chronic neurologic condition and affects peoples at all ages. Seizure clusters are generally referred to seizures that occur at close intervals with complete recovery between attacks. Various studies have reported a variety of ...
Background: Considering the importance of the repairing time in patients with biliary duct injury, the aim of this study was to evaluate the outcomes of patents with bile duct injury following cholecystectomy. Methods: In this cross sectional study that ...
Selective IgM Deficiency (SIgMD) is a recently incorporated disorder in the classification of primary immunodeficiency diseases. The purpose of this study was to present detailed clinical and immunological features in a cohort of 62 adult patients with ...
Rheumatoid arthritis (RA) is a debilitating autoimmune disease that causes progressive chronic inflammation of the joints and destruction of articular cartilage and bone erosion. Cartilage destruction is a key characteristic in patients with RA. RA fibroblast-like ...
Single cell network profiling (SCNP) is a multi-parameter flow cytometry based approach that allows for the simultaneous interrogation of intracellular signaling pathways in multiple cell subpopulations within heterogeneous tissues, without the need for ...
T helper (Th) cells and their cytokines play a pleiotropic role in the pathogenesis of systemic lupus erythematosus (SLE). Recently, a new effector T cell subset, Th9 cells, which preferentially secrete IL-9, has been identified. IL-9 is mainly produced ...
Cell-free hemoglobin (Hb) resulting from hemolysis is redox-active. It disrupts the oxidoreducing microenvironment, shifting the balance unfavorably towards tissue cytotoxicity. Thus, immediate suppression of the Hb-redox activity and removal of the cell-free ...
Background: Gastrointestinal (GI)-related autoantibodies (Abs) are rarely evaluated in autoimmune diseases (AID) other than inflammatory bowel disease, autoimmune hepatitis and celiac disease. Our aim was to determine the prevalence of these antibodies ...
The nuclear translocation and accumulation of IκBα represents an important mechanism regulating transcription of NFκB-dependent pro-inflammatory and anti-apoptotic genes. The nuclear accumulation of IκBα can be ...
Sphingosine 1-phosphate (S1P) is a lipid metabolite with intra- and extracellular signalling properties. It activates five G protein-coupled cell surface receptors designated S1P-receptors type 1-5 (S1P[1-5] ) that transmit extracellular signals into ...
Diabetes mellitus is characterized by chronic hyperglycemia caused by a deficiency in insulin action, insulin secretion or both. Type 1 diabetes is classified as the destruction of beta cells leading to a deficiency in insulin production. Type1 diabetes ...
An overview of the current literature is showing that autoantibodies (AutoAbs) against cytokines are produced in several pathological conditions, including autoimmune diseases, but can also be detected in healthy individuals. In autoimmune diseases, these ...
Asthma is a chronic inflammatory disease that can be difficult to manage due to a lack of diagnostic biomarkers and an incomplete understanding of the molecular pathogenesis. MicroRNAs (miRNAs) are small, single-stranded, non-coding RNAs with increasing ...