We demonstrated a successful case of surgical treatment of the patient with metastatic lesion of upper cervical spine with respect to multidisciplinary approach. We performed simultaneous two-stage surgical intervention, the first stage being occipitospondylodesis by multi-segment construction; and second —tumor resection from expanded combined access. It has been stated that the...
The goal is to study the morphofunctional changes in the kidneys under the influence of light desynchronosis, an analysis of the degree of reversibility of these changes. Material and Methods. The study was carried out in two stages on 72 white male rats. In the first series of experiments, animals underwent round-the-clock light exposure for 10 and 21 days. In the second series...
Aim: to study the functional status of the vascular endothelium and the activity of the hemocoagulation system, as well as the relationship between some indicators characterizing their state in patients with benign and malignant skeleton neoplasms. Material and Methods. 62 patients with benign (45) and malignant (17) bone neoplasms and 10 healthy individuals of the control group...
Aim: to reveal certain mechanisms of the pathogenesis of implant-associated inflammation by the level of resorption and bone tissue genesis markers in patients who underwent primary knee arthroplasty. Material and Methods. Main group consisted of 40 patients with implant-associated inflammation; first comparison group — of 20 patients with primary aseptic loosening of knee joint...
Aim: comparative assessment of the state of joint (hyaline) cartilage, pro-inflammatory component of cytokine profile and enzyme element of blood antioxidant system in healthy individuals and patients at the early stages of gonarthrosis. Materials and Methods. The content of cartilage oligomeric matrixprotein (COMP), superoxide dismutase-2 (mitochondrial) (SOD-2) and interleukin...
Aim: to analyze polymorphic variants of genes of connective tissue remodeling, biotransformation and their role in the development of cardiovascular comorbidity and osteoarthritis (OA). Material and Methods. The study included 70 patients with OA. As a control group, 30 patients without OA of comparable sex and age were included in the study. All patients were assessed total...
Aim: to study the role of microbial associations in the etiology of implant-associated infection, the peculiarities of associates antibiotic resistance, to propose informative methods for the microbiological diagnostics of mixed infections. Material and Methods. The biological samples from 488 patients with infectious complications after total knee replacement were studied...
Aim: to demonstrate the necessity of modern methods of morphological verification in the differential diagnostics of primary and secondary neoplastic lesion of spinal cord. It is shown that histogenesis of tumor cells should be regarded from the viewpoint of comparative assessment of traditional and complementary methods of morphological verification that outlines the necessity...
The data on the methods and promising areas of investigations potent to improve diagnostic tactics in patients with infectious complications after total knee replacement is presented.
Aim: to estimate the outcomes of the method of controlled growth in the correction of axial deformities of lower extremities in children. Material and Methods. We fulfilled the analysis of surgical results of 37 children aged 3-13 yrs. with leg axial deformities, valgus (20) and varus (17) leg deformities at the level of knee joints. All patients were operated in the growth area...
We outlined and described basic directions of national traumatology development at the period of 1950-1980 illustrated by the example of Saratov traumatological school, estimated the contribution of SarNIITO traumatologists into this development at the abovementioned period, depicted syna — one of the founders of acute trauma clinics.
Aim: to estimate biocompatibility of matrices produced from polycaprolactone (PCL) and mineralized by vaterite (CaC03) by studying local and systemic manifestations of inflammatory reaction in subcutaneous implantation tests in white rats. Material and Methods. The experiment was conducted on 40 rats divided into four equal groups: control, comparison (rats with imitation of...
The article contains domestic and foreign data reflecting epidemiological peculiarities of traumatic injuries of spine and spinal cord, their character and incidence among various population groups with respect to gender and age parameters. The study outlines spine and spinal cord injury structure with regard to modern classification schemes, introduces injury incidence data...
Aim: to study the correlations of structural disorders of articular hyaline cartilage with changes in concentration of pro- and anti-inflammatory cytokines at the early stages of osteoarthritis. Material and Methods. Ultrasound and MRI investigations of knee joints (T2*-relaxometry) were performed to 67 females of main group aged 35-50 with initial manifestations of (0-1 stages...
Aim: to determine the diagnostic significance of thrombin generation test parameters in the diagnostics of hemostatic disorders in patients with osteoarthritis of large joints in preoperative period. Material and Methods. 137 subjects have been investigated, among whom there were 115 hip and knee osteoarthritis patients, submitted for primary arthroplasty (68) and re-prosthetics...
Aim: to analyze the method of choice of treatment for children aged 1-3 yrs. with hip joint dysplasia with respect to the complex of pathological changes by the elaboration of CAD programs. Material and Methods. We defined the grade of dysplastic changes in joint components of 82 children with hip joint dysplasia (113 joints) aged 1-3 yrs by CAD program. Results. The grade of...
The review illustrates various approaches to the potential of minimally invasive surgery in forefoot static deformities treatment. We demonstrated that methods aimed at the performance of nonlocking wedge osteotomy of first metatarsal bone and of proximal phalanx of big toe with preservation of cortex wedge contralateral to the base as well as of central metatarsal, extending...
The article represents the history of the Hospital Therapy Department at the Saratov State Medical University served as a basis for new departments' organization. The stages of its development are highlighted.
The article highlights debatable questions concerning the effectiveness of surgical treatment of osteoporotic vertebral fractures. The reasons of unsuccessful outcomes of vertebroplasty are analyzed. A combined method of surgical treatment is proposed, including vertebroplasty and full-endoscopic foraminotomy with a combination of local and ra-dicular pain syndrome caused by...
Aim: to study the sexual dimorphism of the concentration in the blood of endothelial alteration factors in the dynamics of the surgical treatment of moderate chronic generalized periodontitis (CGP) in comparison with clinically healthy volunteers. Material and Methods. A total of 20 clinically healthy volunteers (average age is 30 (24; 37), 50% are men) and 31 patients with...
The article presents a clinical case of systemic lupus erythematosus with severe thrombocytopenia in a 55 year old patient. The standard therapy of usage of high doses of glucocorticoids, cyclophosphamide and intravenous im-munoglobulin was not effective. Application of Rituximab improved the course of disease, decreased the severity of thrombocytopenia, led to disappearance of...
An accurate assessment of renal function is critical for adequate dosing of medications. The most informative marker reflecting the functional state of the kidneys is glomerular filtration rate (GFR). Determination of inulin clearance is the most accurate way to assess GFR in children and adults. In this case, the method is invasive, cumbersome, younger children require the...
The article states the biographical information about Professor G. N. Zakharova, describing her academic contribution into the development of surgery, health care organization and training of academic staff of Saratov Medical Institute.
The article traces the professional path of Professor Lev Yakovlevich Livshits, assesses his scientific contribution to the development of national neurosurgery. The concept of minimally invasive surgical treatment of trigeminal nerve neuralgia, developed by L. Ya. Livshits, allowed developing an original method of puncture surgical treatment of pain syndrome by directed...
The professionalism of a doctor is determined not only by scientific knowledge, but also by high moral qualities. Aim is the formation of the social competencies of the students of the medical university, concerning the personal qualities of the doctor. The authors used a self-developed questionnaire, which included questions relating to patients' characteristics (gender, level...