Human Reproduction

Depolarization of sperm membrane potential is a common feature of men with subfertility and is associated with low fertilization rate at IVF

STUDY QUESTION Are significant abnormalities in outward (K+) conductance and resting membrane potential (Vm) present in the spermatozoa of patients undertaking IVF and ICSI and if so, what is their functional effect on fertilization success?

A nod is as good as a wink to a blind horse: round 2

Anti-Müllerian hormone serum concentrations of women with germline BRCA1 or BRCA2 mutations

STUDY QUESTION Do women with BRCA1 or BRCA2 mutations have reduced ovarian reserve, as measured by circulating anti-Müllerian hormone (AMH) concentration?

Effectiveness of bilateral tubotubal anastomosis in a large outpatient population

STUDY QUESTION Is bilateral tubotubal anastomosis a successful treatment in an outpatient patient population?

Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: a pilot cohort study

STUDY QUESTION Could cell therapy using autologous peripheral blood CD133+ bone marrow-derived stem cells (BMDSCs) offer a safe and efficient therapeutic approach for patients with refractory Asherman's syndrome (AS) and/or endometrial atrophy (EA) and a wish to conceive?

ESHRE Guideline: management of women with premature ovarian insufficiency†

STUDY QUESTION What is the optimal management of women with premature ovarian insufficiency (POI) based on the best available evidence in the literature?

Single-cell transcriptome analysis of endometrial tissue

STUDY QUESTION How can we study the full transcriptome of endometrial stromal and epithelial cells at the single-cell level?

Proteomic characterization of macro-, micro- and nano-extracellular vesicles derived from the same first trimester placenta: relevance for feto-maternal communication

STUDY QUESTION What proteins are carried by extracellular vesicles (EVs) released from normal first trimester placentae?

Revised guidelines for good practice in IVF laboratories (2015)†

STUDY QUESTION Which recommendations can be provided by the European Society of Human Reproduction and Embryology Special Interest Group (ESHRE SIG) Embryology to support laboratory specialists in the organization and management of IVF laboratories and the optimization of IVF patient care?

Ectopic pregnancy morbidity and mortality in low-income women, 2004–2008

STUDY QUESTION Does the risk of adverse outcomes at the time of ectopic pregnancy vary by race/ethnicity among women receiving Medicaid, the public health insurance program for low-income people in the USA?

Cumulative live birth rates after one or more complete cycles of IVF: a population-based study of linked cycle data from 178 898 women

STUDY QUESTION What is the chance of a live birth following one or more linked complete cycles of IVF (including ICSI)?

A prospective, open-label, single arm, multicentre study to evaluate efficacy, safety and acceptability of pericoital oral contraception using levonorgestrel 1.5 mg

STUDY QUESTION Will the use of levonorgestrel (LNG) 1.5 mg taken at each day of coitus by women who have relatively infrequent sex be an efficacious, safe and acceptable contraceptive method?

Semen quality improves marginally during young adulthood: a longitudinal follow-up study

STUDY QUESTION Does semen quality improve during early adulthood?

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health

STUDY QUESTION How does a genetic variant in the FSHB promoter, known to alter FSH levels, impact female reproductive health?

Human anogenital distance: an update on fetal smoke-exposure and integration of the perinatal literature on sex differences

STUDY QUESTION Do sex and maternal smoking effects on human fetal anogenital distance (AGD) persist in a larger study and how do these data integrate with the wider literature on perinatal human AGD, especially with respect to sex differences?

Timing of human preimplantation embryonic development is confounded by embryo origin

STUDY QUESTION To what extent do patient- and treatment-related factors explain the variation in morphokinetic parameters proposed as embryo viability markers?

A spontaneous increase in intracellular Ca2+ in metaphase II human oocytes in vitro can be prevented by drugs targeting ATP-sensitive K+ channels

STUDY QUESTION Could drugs targeting ATP-sensitive K+ (KATP) channels prevent any spontaneous increase in intracellular Ca2+ that may occur in human metaphase II (MII) oocytes under in vitro conditions?

Assisted reproductive technology in Europe, 2011: results generated from European registers by ESHRE†

STUDY QUESTION The 15th European IVF-monitoring (EIM) report presents the results of treatments involving assisted reproductive technology (ART) initiated in Europe during 2011: are there any changes in the trends compared with previous years?

‘How to count sperm properly’: checklist for acceptability of studies based on human semen analysis

STUDY QUESTION Can a tool be developed for authors, reviewers and editors of the ESHRE Journals to improve the quality of published studies which rely on semen analysis data?

Modified natural cycle IVF for poor ovarian responders: rethink before concluding

Reply: First do no harm: continuing the uterine NK cell debate

Consistent and reproducible outcomes of blastocyst biopsy and aneuploidy screening across different biopsy practitioners: a multicentre study involving 2586 embryo biopsies

STUDY QUESTION Is blastocyst biopsy and quantitative real-time PCR based comprehensive chromosome screening a consistent and reproducible approach across different biopsy practitioners?

Assisted reproductive technology use and outcomes among women with a history of cancer†

STUDY QUESTION How do the assisted reproductive technology (ART) outcomes of women presenting for ART after cancer diagnosis compare to women without cancer?

Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes

STUDY QUESTION Is the postovulatory aging-dependent differential decrease of mRNAs and polyadenylation of mRNAs coded by maternal effect genes associated with altered abundance and distribution of maternal effect and RNA-binding proteins (MSY2)?

It takes two to tango: information-sharing with offspring among heterosexual parents following identity-release sperm donation

STUDY QUESTION How do heterosexual parents reason about and experience information-sharing with offspring following identity-release sperm donation?