Human Reproduction

Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues.Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues.

List of Papers (Total 9,882)

Absence or presence? Complexities in the donor narratives of single mothers using sperm donation

STUDY QUESTION How do single mothers who have conceived a child via anonymous or identity-release sperm donation represent the donor?

The Thessaloniki ESHRE/ESGE consensus on diagnosis of female genital anomalies†

STUDY QUESTION What is the recommended diagnostic work-up of female genital anomalies according to the European Society of Human Reproduction and Embryology (ESHRE)/European Society for Gynaecological Endoscopy (ESGE) system?

A single baseline ultrasound assessment of fibroid presence and size is strongly predictive of future uterine procedure: 8-year follow-up of randomly sampled premenopausal women aged 35–49 years

STUDY QUESTION How well can a single baseline ultrasound assessment of fibroid burden (presence or absence of fibroids and size of largest, if present) predict future probability of having a major uterine procedure?

Dynamic comparisons of high-resolution expression profiles highlighting mitochondria-related genes between in vivo and in vitro fertilized early mouse embryos

STUDY QUESTION Does in vitro fertilization (IVF) induce comprehensive and consistent changes in gene expression associated with mitochondrial biogenesis and function in mouse embryos from the pre- to post-implantation stage?

Outcomes of transplantations of cryopreserved ovarian tissue to 41 women in Denmark

STUDY QUESTION What are the results of transplanting cryopreserved ovarian tissue?

Developmental clock compromises human twin model created by embryo splitting

STUDY QUESTION Is the quality of the human embryos generated by twinning in vitro comparable to the quality of the embryos created by fertilization?

Evidence from the very beginning: endoglandular trophoblasts penetrate and replace uterine glands in situ and in vitro

STUDY QUESTION How is histiotrophic nutrition of the embryo secured during the first trimester of pregnancy?

Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa

STUDY QUESTION Are significant abnormalities of CatSper function present in IVF patients with normal sperm concentration and motility and if so what is their functional significance for fertilization success?

Cumulative live birth rate: time for a consensus?

Traditionally, IVF success rates have been reported in terms of live birth per fresh cycle or embryo transfer. With the increasing use of embryo freezing and thawing it is essential that we report not only outcomes following fresh but also those after frozen embryo transfer as a complete measure of success of an IVF treatment. Most people agree that an individual's chance of...

Why do niches develop in Caesarean uterine scars? Hypotheses on the aetiology of niche development

Caesarean section (CS) results in the occurrence of the phenomenon ‘niche’. A ‘niche’ describes the presence of a hypoechoic area within the myometrium of the lower uterine segment, reflecting a discontinuation of the myometrium at the site of a previous CS. Using gel or saline instillation sonohysterography, a niche is identified in the scar in more than half of the women who...

Diminished ovarian reserve is not observed in infertility patients with high normal CGG repeats on the fragile X mental retardation 1 (FMR1) gene

STUDY QUESTION Does an association exist between high normal numbers of CGG trinucleotide repeats on the fragile X mental retardation 1 (FMR1) gene and diminished ovarian reserve (DOR)?

Provision of intrauterine contraception in association with first trimester induced abortion reduces the need of repeat abortion: first-year results of a randomized controlled trial

STUDY QUESTION Can the need of subsequent abortion be reduced by providing intrauterine contraception as a part of the abortion service?

Sperm freezing to address the risk of azoospermia on the day of ICSI

STUDY QUESTION In which cases is freezing of ejaculated sperm indicated before ICSI?

ESHRE guideline: routine psychosocial care in infertility and medically assisted reproduction—a guide for fertility staff†

STUDY QUESTION Based on the best available evidence in the literature, what is the optimal management of routine psychosocial care at infertility and medically assisted reproduction (MAR) clinics?

A European perspective on testicular tissue cryopreservation for fertility preservation in prepubertal and adolescent boys†

STUDY QUESTION What clinical practices, patient management strategies and experimental methods are currently being used to preserve and restore the fertility of prepubertal boys and adolescent males?

Pain typology and incident endometriosis

STUDY QUESTION What are the pain characteristics among women, with no prior endometriosis diagnosis, undergoing laparoscopy or laparotomy regardless of clinical indication?

Expression of melanocortin receptors in human endometrium

STUDY QUESTION Are melanocortin receptors (MCR1-5) expressed in the endometrium?

Androgen levels in women with various forms of ovarian dysfunction: associations with cardiometabolic features

STUDY QUESTION Are differences in androgen levels among women with various forms of ovarian dysfunction associated with cardiometabolic abnormalities?

Is IVF—served two different ways—more cost-effective than IUI with controlled ovarian hyperstimulation?

STUDY QUESTION What is the cost-effectiveness of in vitro fertilization (IVF) with conventional ovarian stimulation, single embryo transfer (SET) and subsequent cryocycles or IVF in a modified natural cycle (MNC) compared with intrauterine insemination with controlled ovarian hyperstimulation (IUI-COH) as a first-line treatment in couples with unexplained subfertility and an...

Differences in gene expression profiles between human preimplantation embryos cultured in two different IVF culture media†

STUDY QUESTION Is gene expression in human preimplantation embryos affected by the medium used for embryo culture in vitro during an IVF treatment?